Toward a sensible single antigen bead cut-off based on kidney graft survival

Background There is no consensus in the literature on the interpretation of single antigen bead (SAB) positive for a specific HLA antibody. Methods To inform the debate, we studied the relationship between various SAB positivity algorithms and the impact of resulting donor-specific HLA antibody (DSA) positivity on long-term kidney graft survival in 3237 deceased-donor transplants. Results First, we showed that the interassay variability can be greatly reduced when working with signal-to-background ratios instead of absolute MFIs. Next, we determined pretransplant DSA using various MFI cut-offs, signal-to-background ratios (STBR) and combinations thereof. The impact of the various cut-offs was studied by comparing the graft survival between the DSA-positive and DSA-negative groups. We did not observe a strong impact of various cut-off levels on 10-year graft survival. A stronger relationship between the cut-off level and 1-year graft survival for DSA-positive transplants was found when using STBR, most pronounced for the bead of the same HLA-locus with lowest MFI taken as background. Conclusions With respect to pretransplant risk stratification, we propose a SBTR-6 (using the bead of the same HLA-locus with lowest MFI as background) cut-off of 15 combined with an MFI cut-off of 500, resulting in 8% and 21% lower 1- and 10-years graft survival, respectively, for 8% DSA positive transplants. Corresponding author: E-mail address: H.G.Otten@umcutrecht.nl. Corresponding author permanent address: Laboratory of Translational Immunology, University Medical Center Utrecht, F.03.821, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Tel.: +31 88 75 57680 Disclosure The authors of this manuscript have no conflicts of interest to disclose. Authorship Participated in research design: BW, EK, AD, LP, HO Participated in writing of the paper: BW, EK, IJ, WA, LH, AvZ, MV, MLB, BH, AL, LB, CR, CV, ItB, AH, SH, DR, FC, HO Participated in the performance of the research: BW, EK, AD, LP Contributed new reagents or analytic tools: BW, EK, IJ, WA, AvdM, LH, MCB, ES, CH, FvR, AvZ, MV, MLB, AD, LP, MS, JS, BH, AL, LB, CR, MT, CV, LW, EvD, MG, MC, FvI, AN, NL, WS, KvdP, NvdW, ItB, FB, AH, PvdB, JdF, MB, SH, DR, FC, HO Participated in data analysis: BW, EK, HO Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2P7LDbI

The Metabolic Syndrome and Health Behaviors in School Children Aged 13–16 Years in Ubon Ratchathani: UMeSIA Project

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2KPWYtG

Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care

Thyroid, Ahead of Print.


https://ift.tt/2MMEpIE

Surgical Confirmation of Incomplete Treatment for Primary Papillary Thyroid Carcinoma by Percutaneous Thermal Ablation: A Retrospective Case Review and Literature Review

Thyroid, Ahead of Print.


https://ift.tt/2MogmTq

Low Iodine Intake from Dairy Foods Despite High Milk Iodine Content in Israel

Thyroid, Volume 28, Issue 8, Page 1042-1051, August 2018.


https://ift.tt/2MNBbEA

Morgellons disease: A review of a mysterious psychodermatologic disorder

Introduction: Morgellons disease is a rare, unexplained skin disorder that whose specific etiology remains a mystery to both the Dermatologic and Psychiatric community as the specific etiology remains unknown. The condition is characterized by the physical presentation of painful sores with reported crawling sensations within the skin and the fixed belief of infection or parasitic infestation. The pathognomonic feature of this disease is the presence of filaments or fibers embedded in and emerging from these sores.

https://ift.tt/2MK5Xyo

Effectiveness of the Eczema Action Plan (EAP) in improving the Eczema Area and Severity Index (EASI) scores among pediatric patients with atopic dermatitis: A pragmatic randomized controlled trial

Introduction: Atopic dermatitis (AD) is a chronically relapsing skin disease that occurs most commonly during early infancy and childhood. Education about the condition is vital in helping patients and their caregivers understand the nature of the disease. Evidence show that adherence is poor. There are no reported studies on interventions done so far to increase treatment adherence among patients with atopic dermatitis in the local setting. This study aims to improve treatment adherence among patients with atopic dermatitis through improvement of the EASI scores.

https://ift.tt/2MjA03C

Photocarcinogenic risks of narrowband ultraviolet B therapy and psoralen + ultraviolet A therapy

Introduction: Narrowband UVB Therapy and Psoralen + UVA therapy are widely used in the treatment of several skin disorders. Although short-term security has been demonstrated, there are several concerns about long term security and, in particular, the risk of skin cancer after NB-UVB and PUVA therapy.

https://ift.tt/2nKWJqR

Hemorrhagic vesiculobullous erythema migrans: An atypical presentation of Lyme disease

Background: Erythema migrans (EM) is the most well known cutaneous manifestation of Lyme disease. Review of the literature and the case described below suggest that atypical cutaneous presentations, such as vesiculobullous EM, can occur and must remain in the differential diagnosis in the proper clinical setting.

https://ift.tt/2MMr7Mg

Computer-based video instruction of dermatologic procedures for training medical students: A blinded randomized controlled trial

Purpose: Medical students receive 10-26 hours of dermatology education throughout their curriculum. Most procedural training is based largely on an apprenticeship model, which results in wide variability in the level of technical skills acquired during undergraduate medical training. No standardized methodology exists to teach dermatologic skills to preclinical medical students. The purpose of this study was to investigate the significance of computer-based video instruction (CBVI) to augment in-person simulation based instruction to train medical students in shave biopsy techniques.

https://ift.tt/2MeyTSO

Nevus simplex on the midline of the forehead

Background: Recently, studies reported medial frontofacial capillary malformation (CM) that appeared like nevus simplex (NS), but differed in that the lesion had a wider median topography and darker color, and faded more slowly or incompletely.

https://ift.tt/2MMqYZe

Evaluation in real life of an adapted information impact for effective photoprotection: An example with patients with actinic keratosis

Introduction: Cutaneous actinic keratosis lesions preferentially affect people with clear skin and indicate an excess of solar exposure. Actinic keratosis can be esthetically troublesome and require a medical care with consultations at regular intervals to allow the dermatologist the detection of a possible development toward a skin cancer. Whatever the treatment chosen by the dermatologist, the medical care is always the opportunity to inform and educate people about the necessity of an effective photoprotection to avoid the risk of recurrence.

https://ift.tt/2MNf4OI

Demographic and health care service utilization by 4,417 patients with hidradenitis suppurativa

Background: Data on the health care utilization of hidradenitis suppurativa (HS) patients in primary care settings are scarce.

https://ift.tt/2nKWBHT

Out of the blue and into the black

Introduction: ANCA-associated vasculitides (AAV) are systemic vasculitides involving small to medium vessels and are divided into three separate clinical entities with many overlapping and some distinctive features. Here we present a case having features of all three AAV, including microscopic polyangiitis, granulomatosis with polyangiitis, and eosinophilic granulomatosis with polyangiitis.

https://ift.tt/2nDyf2D

Levocarnitine for vismodegib-associated muscle spasms: A pilot randomized, double-blind, placebo-controlled, investigator-initiated trial

Background: Smoothened inhibitors (SIs) are a new targeted therapy approved by the United States Food and Drug Administration (FDA) for the treatment of advanced basal cell carcinoma (BCC). However, no placebo-controlled studies exist on management of their most common side-effect, muscle spasms, which affect up to 80% of patients taking SIs and are the most common reason for drug discontinuation despite tumor response. Based on anecdotal observations of exercise exacerbating SI-associated spasms, and existing evidence that levocarnitine (LC) can reduce markers of exercise induced stress, we explored the effect of oral LC usage on muscle spasms occurring after initiation of vismodegib, an SI.

https://ift.tt/2MKllux

Impact of surfactant-phase chemistry on skin mildness: Lamellar surfactants provide significant mildness benefits compared with conventional micellar surfactants

Background: Surfactants make up the dominant components in most skin cleansing formulas and are key determinants of a product's performance. It is well known that these surfactants can compromise the stratum barrier function and skin hydration, largely due to surfactant penetration into deeper layers of the stratum corneum and causing disruption of stratum corneum lipids and proteins. It is important to minimize surfactant-induced skin surface damage by developing advanced skin cleansing technologies with improved skin mildness and reduced surfactant penetration into the stratum corneum.

https://ift.tt/2nKWs7j

From relative to absolute treatment outcomes—Correlation of PASI 90 and PASI ≤2 in three clinical trials with secukinumab

Introduction: Relative improvement of psoriasis area and severity index (PASI) during treatment compared with baseline PASI is the current standard definition of response in trials and practice. A ≥75% improvement in PASI (PASI 75) is the current treatment goal in international guidelines. With the advent of more effective biologic treatments, an improvement by ≥90% (PASI 90) is under consideration as a new treatment goal. As an alternative for long-term management, baseline-independent absolute PASI treatment goals are being discussed.

https://ift.tt/2MQUYDq

Elephantiasic pretibial myxedema, chronic and recalcitrant thyroid dermopathy

Patients afflicted with autoimmune thyroiditis, specifically Graves disease, can have extrathyroidal manifestations such as exophthalmos, thyroid dermopathy, and acropachy. Thyroid dermopathy usually presents as pretibial myxedema (PTM) due to its predilection for the pretibial area. In severe forms of PTM, it can present as the elephantiasic form, which is notoriously resistant to conventional treatment. Due to the disease rarity, only a few case reports of elephantiasic PTM exist in the literature.

https://ift.tt/2nKWn3v

Correlation of d-dimers to response to treatment in chronic spontaneous urticaria (UAS7 score): Results from the SUNRISE study

Objectives: Increased levels of blood d-dimers (D-D), the by-products of fibrin degradation, are linked to the severity of chronic spontaneous urticaria (CSU) and to poor response to antihistamines H1 (AH1). Omalizumab (OMA) is a human monoclonal anti–immunoglobulin E antibody registered as an add-on treatment of CSU in adults and adolescents (≥12 years old) with insufficient response to AH1. The SUNRISE study assessed the efficacy of Omalizumab on CSU symptoms and the correlation between D-D levels and response over time to treatment with OMA to explore its potential predictive value.

https://ift.tt/2w6oYUt

Cutaneous lymphangitic carcinomatosis associated with parotid gland duct carcinoma: An unreported case

Introduction: Salivary duct carcinoma of parotid gland is an uncommon neoplasm exceptionally associated with cutaneous metastasis. We described an unreported association of cutaneous lymphangitic carcinomatosis from parotid gland duct carcinoma in a 67-year-old woman.

https://ift.tt/2nGe6ZI

Clinical characteristics and outcomes of patients with superficial venous thrombosis at multiple sites simultaneously

Background: Superficial venous thrombosis (SVT) results from thrombus formation within a superficial vein that is associated with inflammation of the surrounding tissue, and classically presents with pain, tenderness, induration, and/or erythema in the form of a palpable cord. Although traditionally considered a local, benign disorder, recent studies demonstrate that patients with SVT are at significant risk for deep vein thrombosis (DVT), pulmonary embolism (PE), and other venous thromboembolic (VTE) events.

https://ift.tt/2MLGGDY

Porokeratosis ptychotropica: A differential diagnosis for “psoriasis” of the gluteal region

A 51-year-old man presented with an 8-year history of a well demarcated erythematous scaly plaque on the buttocks, extending into the natal cleft. Initial skin biopsy was reported as showing features of psoriasis. Treatment with topical calcipotriol, acitretin, UVB and intralesional triamcinolone were ineffective. Repeat biopsies taken from two different areas showed neutrophilic collections within the stratum corneum and a psoriasiform pattern of hyperplasia supporting the initial diagnosis of psoriasis.

https://ift.tt/2nFVPfe

Extensive abdominal wall ulceration as a late manifestation of antiphospholipid syndrome: a case report

Antiphospholipid syndrome is an autoimmune disorder characterized by the presence of antiphospholipid antibodies and commonly presents with vascular thromboembolic phenomena, thrombocytopenia, and obstetric co...

https://ift.tt/2nADEHA

Unilateral pulmonary edema: a case report and review of the literature

Unilateral pulmonary edema is an uncommon condition and is a rare clinical entity that is often misdiagnosed at the initial stages. In a majority of patients it occurs in the upper lobe of the right lung. Ther...

https://ift.tt/2KOeRZT

Aflatoxin M 1 levels in different marketed milk products in Nairobi, Kenya

Abstract

Milk is an important source of energy and nutrients, especially for children, and in Kenya, milk consumption is higher than other countries in the region. One major concern with milk is the risks of chemical contaminants, and reports of high levels of aflatoxin M₁ (AFM₁) in milk in Kenya has been causing public health concerns. This study collected marketed milk products every month during 1 year, just as a consumer would purchase them from retailers and traders in a low-income area, and a major supermarket in a middle/high-income area. In total, 291 sampled milk products (raw, pasteurised, UHT milk, yoghurt and lala) were collected and analysed for AFM₁ using a commercial ELISA kit. More than 50% of the samples exceeded 50 ng/kg (the level allowed in the EU), but only three samples exceeded 500 ng/kg (the level allowed in the USA). Geometric mean AFM₁ level was 61.9 ng/kg in the 135 samples from the low-income area while it was 36.1 ng/kg in the 156 from the higher income area (p < 0.001). The levels varied significantly depending on the time of year, with lowest levels of milk in January. There were also differences between manufacturers and products, with UHT milk having lower levels. There was no difference depending on the price for all dairy products, but when only including milk, higher price was associated with lower levels of AFM₁. In conclusion, this study shows that milk purchased by a consumer is likely to contain AFM₁ above 50 ng/kg, and that further research is needed to find ways to mitigate AFM₁ contamination through working with farmers and milk processors both in the formal and informal sectors.

https://ift.tt/2Pb3wGM

Clinical Thyroidology®for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Thyroid hormone is necessary for development and growth of brain in developing babies during pregnancy. Studies have shown that hypothyroidism and low thyroid hormone levels without hypothyroidism may be associated with some developmental problems in children. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^®for the Public – Highlighted Article appeared first on American Thyroid Association.

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Slow, slurred speech as an initial complaint in amyotrophic lateral sclerosis

Otorhinolaryngologic examinations at an early stage, particularly those conducted by vocal specialists, can make potentially important contributions to the diagnosis of bulbar-onset ALS patients.

https://ift.tt/2BdtoP6

Kimishige Ishizaka (1925–2018)

Publication date: Available online 14 August 2018

Source: Allergology International

Author(s): Hirohisa Saito

https://ift.tt/2P6vwvb

Risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: A systematic review with meta-analyses

Publication date: October 2018

Source: Oral Oncology, Volume 85

Author(s): Harry Karna, Jaime Gonzalez, Harveen S. Radia, Parish P. Sedghizadeh, Reyes Enciso

Abstract

The purpose of this systematic review with meta-analysis was to assess the effectiveness of dental interventions in preventing or reducing the incidence of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients receiving antiresorptive therapy, compared to similar control groups receiving no intervention. Randomized controlled trials (RCT), case-controls and cohorts on cancer patients with primary outcome being the prevalence of MRONJ were included. Four electronic databases were searched (Cochrane Library, PubMed, EMBASE and Web of Science) up to February 12, 2018. A total of 409 abstracts were assessed and one case-control, one RCT and four cohort studies with 2332 cancer patients met our inclusion criteria. Risk of bias analysis followed Cochrane's handbook. Risk of bias was unclear for the case-control study and high risk for the RCT and all cohort studies. Five studies utilized preventive measures consisting of an initial examination and performing all necessary dental treatment before patients initiated antiresorptive therapy; one study used specialized post-extraction protocols utilizing plasma-rich in growth factors (PRGF) on cancer patients receiving antiresorptive therapy. Though dental preventive measures decreased MRONJ incidence by 77.3% in six studies with 2332 cancer patients (95% CI = 47.4–90.2%; p = .001) compared to control groups, quality of the evidence was low due to high or unclear risk of bias and the observational nature of five of the included studies. In conclusion, high-quality long-term prospective large sample size studies are needed to confirm these results due to high risk of bias and heterogeneous interventions. No funding.

https://ift.tt/2vJ2sSh

Correction for Burdyga et al., Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane [Correction]

CELL BIOLOGY Correction for "Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane," by Alex Burdyga, Nicoletta C. Surdo, Stefania Monterisi, Giulietta Di Benedetto, Francesca Grisan, Elisa Penna, Luca Pellegrini, Mario Bortolozzi, Pawel Swietach, Tullio Pozzan, and Konstantinos Lefkimmiatis, which was first published June 25, 2018; 10.1073/pnas.1806318115 (Proc Natl...

https://ift.tt/2KUyn70

Correction for Kang and Lubensky, Chiral twist drives raft formation and organization in membranes composed of rod-like particles [Correction]

PHYSICS, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for "Chiral twist drives raft formation and organization in membranes composed of rod-like particles," by Louis Kang and Tom C. Lubensky, which was first published December 20, 2016; 10.1073/pnas.1613732114 (Proc Natl Acad Sci USA 114:E19–E27). The authors note that a sign error for the...

https://ift.tt/2P9NaOv

Correction for Nojiri et al., Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells [Correction]

MEDICAL SCIENCES Correction for "Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells," by Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Koichi Miura, Shin Ishikane, Kentaro Otani, Ichiro Kishimoto, Yasushi Shintani, Masayoshi Inoue, Toru Kimura, Noriyoshi Sawabata, Masato Minami, Tomoyuki Nakagiri, Soichiro Funaki, Yukiyasu Takeuchi, Hajime Maeda, Hiroyasu Kidoya, Hiroshi...

https://ift.tt/2vIQOqD

Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart [Systems Biology]

Smyd1, a muscle-specific histone methyltransferase, has established roles in skeletal and cardiac muscle development, but its role in the adult heart remains poorly understood. Our prior work demonstrated that cardiac-specific deletion of Smyd1 in adult mice (Smyd1-KO) leads to hypertrophy and heart failure. Here we show that down-regulation of mitochondrial...

https://ift.tt/2Ox9roe

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm [Plant Biology]

The transmission of HIV can be prevented by the application of neutralizing monoclonal antibodies and lectins. Traditional recombinant protein manufacturing platforms lack sufficient capacity and are too expensive for developing countries, which suffer the greatest disease burden. Plants offer an inexpensive and scalable alternative manufacturing platform that can produce multiple...

https://ift.tt/2KWQrxc

Evolution and diversification of the plant gibberellin receptor GID1 [Plant Biology]

The plant gibberellin (GA) receptor GID1 shows sequence similarity to carboxylesterase (CXE). Here, we report the molecular evolution of GID1 from establishment to functionally diverse forms in eudicots. By introducing 18 mutagenized rice GID1s into a rice gid1 null mutant, we identified the amino acids crucial for GID1 activity in...

https://ift.tt/2Mlnr7j

Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70 [Plant Biology]

Plant pathogens deliver effectors into plant cells to suppress immunity. Whereas many effectors inactivate positive immune regulators, other effectors associate with negative regulators of immunity: so-called susceptibility (S) factors. Little is known about how pathogens exploit S factors to suppress immunity. Phytophthora infestans RXLR effector Pi02860 interacts with host protein...

https://ift.tt/2KWQt8i

Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II complex is a seven-bladed beta-propeller protein [Plant Biology]

Robust photosynthesis in chloroplasts and cyanobacteria requires the participation of accessory proteins to facilitate the assembly and maintenance of the photosynthetic apparatus located within the thylakoid membranes. The highly conserved Ycf48 protein acts early in the biogenesis of the oxygen-evolving photosystem II (PSII) complex by binding to newly synthesized precursor...

https://ift.tt/2MlnsIp

Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics [Microbiology]

Understanding of T cell exhaustion and successful therapy to restore T cell function was first described using Clone (Cl) 13 variant selected from the lymphocytic choriomeningitis virus (LCMV) Armstrong (ARM) 53b parental strain. T cell exhaustion plays a pivotal role in both persistent infections and cancers of mice and humans....

https://ift.tt/2KOU8oM

Roles for ClpXP in regulating the circadian clock in Synechococcus elongatus [Microbiology]

In cyanobacteria, the KaiABC posttranslational oscillator drives circadian rhythms of gene expression and controls the timing of cell division. The Kai-based oscillator can be reconstituted in vitro, demonstrating that the clock can run without protein synthesis and degradation; however, protein degradation is known to be important for clock function in...

https://ift.tt/2P7e2yF

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir [Microbiology]

Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 latency, selective estrogen receptor modulators (SERMs, i.e., fulvestrant, raloxifene, and tamoxifen) are weak proviral activators and sensitize cells to latency-reversing...

https://ift.tt/2MOLIiP

Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain [Medical Sciences]

The action of the collagen binding receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) in both tumor and tumor stromal cells has been established as critical for breast cancer metastasis. Small molecule inhibitors that target the extracellular domain of RTKs are rare, as they have classically been regarded as...

https://ift.tt/2Mlfn6v

Osterix functions downstream of anti-Mullerian hormone signaling to regulate Mullerian duct regression [Developmental Biology]

In mammals, the developing reproductive tract primordium of male and female fetuses consists of the Wolffian duct and the Müllerian duct (MD), two epithelial tube pairs surrounded by mesenchyme. During male development, mesenchyme–epithelia interactions mediate MD regression to prevent its development into a uterus, oviduct, and upper vagina. It is...

https://ift.tt/2OxeQM2

Reply to Liu et al.: Decidualization defect in severe preeclampsia [Biological Sciences]

Addressing our first line of evidence of a decidualization defect in severe preeclampsia (sPE) (1), Liu et al. (2) describe an in vitro decidualization model by using an endometrial cell line from hTERT-immortalized fibroblasts of a woman with nonmalignant myomas (ATCC: CRL-4003) with cAMP and medroxyprogesterone acetate for 5 d....

https://ift.tt/2KRuPm7

Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in Caenorhabditis elegans [Biochemistry]

Cell-autonomous and cell-nonautonomous mechanisms of neurodegeneration appear to occur in the proteinopathies, including Alzheimer's and Parkinson's diseases. However, how neuronal toxicity is generated from misfolding-prone proteins secreted by nonneuronal tissues and whether modulating protein aggregate levels at distal locales affects the degeneration of postmitotic neurons remains unknown. We generated and...

https://ift.tt/2PaeImL

Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin [Microbiology]

Poxviruses are large DNA viruses that cause disease in animals and humans. They differ from classical enveloped viruses, because their membrane is acquired from cytoplasmic membrane precursors assembled onto a viral protein scaffold formed by the D13 protein rather than budding through cellular compartments. It was found three decades ago...

https://ift.tt/2MM91dg

Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids [Biochemistry]

We report natural light–oxygen–voltage (LOV) photoreceptors with a blue light-switched, high-affinity (KD ∼ 10−7 M), and direct electrostatic interaction with anionic phospholipids. Membrane localization of one such photoreceptor, BcLOV4 from Botrytis cinerea, is directly coupled to its flavin photocycle, and is mediated by a polybasic amphipathic helix in the linker...

https://ift.tt/2KSx6gL

Promoter-mediated diversification of transcriptional bursting dynamics following gene duplication [Cell Biology]

During the evolution of gene families, functional diversification of proteins often follows gene duplication. However, many gene families expand while preserving protein sequence. Why do cells maintain multiple copies of the same gene? Here we have addressed this question for an actin family with 17 genes encoding an identical protein....

https://ift.tt/2P7egG1

Central role of autophagic UVRAG in melanogenesis and the suntan response [Cell Biology]

UV-induced cell pigmentation represents an important mechanism against skin cancers. Sun-exposed skin secretes α-MSH, which induces the lineage-specific transcriptional factor MITF and activates melanogenesis in melanocytes. Here, we show that the autophagic tumor suppressor UVRAG plays an integral role in melanogenesis by interaction with the biogenesis of lysosome-related organelles complex...

https://ift.tt/2P7ebCd

Future Meetings

Thyroid, Volume 28, Issue 8, Page 1076-1077, August 2018.


https://ift.tt/2BaMHZl

Johns Hopkins Radiation Oncology Pioneer Moody Wharam, M.D., Dies at 77

Moody Wharam Jr., Professor Emeritus of Radiation Oncology and Molecular Radiation Sciences and former Willard and Lillian Hackerman Professor of Radiation Oncology at the Johns Hopkins Kimmel Cancer Center, died on Aug. 10 at age 77.

https://ift.tt/2vL2Y27

Cross-Training for Runners | Staying Healthy and Happy

As we enter the fall season of sports, cross country season is kicking into high gear. Middle and high schoolers across the country are starting to build up the mileage for when meets start in a few weeks. Many of these young athletes will be running six days a week at the peak of the season, giving them little rest and recovery time. A few weeks into this rigorous schedule, my office will be flooded with shin splints, foot pain, etc., from all the time they spend out on the roads. Adding some cross-training (e.g., elliptical, bike, swimming, weight lifting) into this rigorous running schedule is very beneficial and may cause fewer runners to be on the side watching rather than running in the race. The idea of cross-training is also important to year-round runners as well.

Benefits of Cross-Training

• Injury prevention: By adding cross-training, runners who are just getting started can avoid the excessive pounding that can occur, which may alleviate injury. Running a few days a week and then cross-training a few will allow the body to recover between workouts.
• Rehab after an injury: Most runners will experience an injury at some point in their career. Using cross-training is important as they head back to running once they are cleared to do so by a physician. They can build up cardiovascular endurance without relying solely on running as a means to rebuild.
• Improve aerobic fitness: Being able to add in extra workouts can help improve endurance. Your body may only be able to handle 3-4 days per week of running but you have the motivation to do more. Add in reduced impact cross training activities! Aerobic fitness will increase without the risk of injury.
• It mixes things up: If a runner is stuck doing the same runs week after week, running can become monotonous and motivation can decrease. By adding in some different workouts, runners can keep themselves excited about training.

If your child is a cross country or track athlete or is working towards the goal of running more, have them give some consideration to adding cross training to their weekly routine. It will help decrease injuries and will likely be beneficial to running performance.

The post Cross-Training for Runners | Staying Healthy and Happy appeared first on ChildrensMD.

https://ift.tt/2KOvapy

Johns Hopkins Experts Create Opioid Prescribing Guidelines For 20 Common Surgical Procedures

A Johns Hopkins expert panel of health care providers and patients have announced what is, to their knowledge, the nation's first set of operation-specific opioid prescribing guidelines. The guidelines are based on the premise that opioid prescribing limits should be based on the operation performed rather than a blanket approach. The ranges offered for each of 20 common operations generally call for reductions from the current rates of opioid prescription, and the researchers say that patients themselves favor using less of the drugs than physicians often prescribe.

https://ift.tt/2Paeix0

Cetuximab with radiation found to be inferior to standard treatment in HPV-positive oropharyngeal cancer

Results from a randomized clinical trial show patients with HPV-positive oropharyngeal cancer treated with radiation and cetuximab had inferior survival compared to the current standard treatment with radiation and cisplatin. The trial's goal was to find a less toxic treatment approach without compromising survival.

https://ift.tt/2vDkkhp

Gallbladder empyema complicating acute myeloid leukaemia in an adolescent boy

Gallbladder (GB) empyema is an uncommon complication in acute myeloid leukaemia (AML). Non-specific signs and symptoms and rarity of disease in AML make it difficult to diagnose early. We report a case of 13-year-old boy who had AML and developed GB empyema in the neutropaenic period. The patient was managed with antibiotics, ultrasound-guided tapping and interval cholecystectomy and recovered well. GB empyema is a life-threatening complication which should be kept as a possibility while evaluating patients with neutropaenia with pain abdomen localised to right hypochondrium as early diagnosis and treatment can lead to better outcomes.

https://ift.tt/2OEfJmj

Thyroid metastasis from rectal adenocarcinoma

The thyroid is a rare site for metastasis, occurring in 0.1% of colorectal cases. A 46-year-old man with rectal adenocarcinoma developed an enlarging anterior neck mass and increasing carcinoembryonic antigen 2 years after curative intent treatment. Imaging showed aggressive features with invasion of the larynx, trachea and oesophagus, suspicious for anaplastic thyroid carcinoma. The patient underwent tumour debulking with neck dissection and tracheostomy. Final histopathological review revealed metastatic adenocarcinoma from a colorectal primary. Despite chemotherapy, the patient eventually succumbed to disease progression and complications of his illness. This case demonstrates that recognising rare sites of metastasis may help clinicians effectively institute earlier intervention.

https://ift.tt/2MscFvV

Aneurysmal fibrous histiocytoma

Aneurysmal fibrous histiocytoma (AFH) is a type of fibrohistiocytic tumour. We present a case of a patient who presented with a skin papule on the thigh region. Histopathological examination following total excision of the lesion revealed an AFH. No sign of recurrence was present 6 months after surgery.

https://ift.tt/2OzVDJD

Prostatitis, a rare presentation of granulomatosis with polyangiitis, successfully treated with rituximab and prednisone

A previously healthy 21-year-old man presented with an 8-month history of weight loss, lethargy and dysuria unresponsive to empiric antibiotics and paraurethral drainage of a prostatic abscess. Urinalysis showed pyuria, but cultures failed to grow any organisms. Additionally, he developed new onset sensorineural hearing loss. CT of the chest showed two right-sided cavitary lesions. CT of the abdomen and pelvis demonstrated a prostatic abscess. A prostate biopsy demonstrated necrotising granulomatous prostatitis. A lung biopsy showed necrotising granulomatous inflammation. He was diagnosed with granulomatosis with polyangiitis (GPA). He was successfully treated with rituximab and prednisone. At 6-month follow-up, he continued to be in remission with resolution of his symptoms. This case demonstrates a rare presentation of prostatitis as the presenting symptom of GPA. As far as we know, this case is the first documented report of rituximab and prednisone as successful therapy for prostatitis secondary to GPA.

https://ift.tt/2MrNU2S

Epstein-Barr-positive classical Hodgkin lymphoma-associated haemophagocytic lymphohistocytiosis: a rare case

Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, which is usually triggered by autoimmune disorders, viral infections and malignancy, like lymphomas. We present a 60-year-old Hispanic woman with a medical history of hypertension and systemic lupus erythematosus presenting with fever, generalised weakness and shortness of breath for 3 weeks. She was hypotensive on presentation, and a CT scan of abdomen/chest showed multiple irregular hepatic and splenic hypodense lesions. A liver biopsy revealed Classical Hodgkin lymphoma (cHL) with positive Epstein-Barr virus (EBV) staining that was later confirmed with high serum EBV DNA levels. Incidentally, a liver biopsy disclosed haemophagocytosis in some cells. HLH-associated cHL is an uncommon condition that can cause severe systemic symptoms acting as the perfect mimic of septic shock, deviating the clinical eye toward treating with antibiotics and not addressing in a timely manner the real aetiology of the patient's condition.

https://ift.tt/2OyUli0

Post-traumatic aortic pseudoaneurysm causing acquired pulmonary artery stenosis

Description 

A 43-year-old man with a diagnosis of severe pulmonary stenosis was referred to us for pulmonary valve balloon dilatation. We reviewed the case and found that the patient was complaining of progressively increasing dyspnoea over the past one year. He did not complain of chest pain, syncope, limb swelling or cyanosis. History was unremarkable except for a motorbike accident which he suffered 10 years back and sustained injuries over his face, chest and limbs. He made full functional recovery within 2 months after the accident and remained free from any symptoms for the next 9 years.

We reviewed his echocardiogram and found that he had dilated right atrium and right ventricle. Left-sided chambers and valves were normal. The pulmonary valve was normal. Instead, he had supravalvular pulmonary stenosis caused by compression of the pulmonary artery by an extrinsic mass (figures 1 and 2). CT...

https://ift.tt/2OAotJP

Penile fracture after priapism due to sildenafil ingestion: out of frying pan into the fire

Description  

A 36-year-old man presented to our department with complaints of swelling, pain and deformed penis for 2 days. He had a history of 100 mg sildenafil ingestion, following which he sustained a prolonged erection that persisted even after sexual intercourse. He tried vigorous masturbation to relieve it, but he failed. After this exercise, while he was sleeping, his child mistakenly fell over his erect penis, following which he developed sudden severe pain in his penis and lost tumescence. On examination, he had swelling and ecchymosis on the right posterolateral aspect of his penis (figure 1). There was no haematuria or blood at meatus. On the basis of history and physical examination, a diagnosis of penile fracture was made. Ultrasound revealed a tear in the lateral wall of the right corpora cavernosa with a large haematoma. The patient was taken for emergency exploration. Intraoperatively, a defect of approximately 1x1 cm was visualised...

https://ift.tt/2nDvVsp

Aphallia: do sociocultural issues affect treatment decisions?

Description 

Otherwise healthy 1-month-old male patient (documented 46,XY karyotype) was referred to the plastic surgery unit for assessment. Physical exam revealed absence of penis and urethra along with a well-formed scrotum and both normally descended testicles (figure 1). No characteristic facial phenotype was noted. Also, there were no abdominal wall hernias nor abnormalities of the anal canal. An echocardiogram, abdominal ultrasound and CT were performed to exclude other malformations. CT scan revealed a functional but hypoplastic right kidney and the presence of a vesicorectal fistula. The rest of the studies including a hormonal profile were within normal limits.

Figure 1

Picture showing the perineal region of the patient.

Surgical fistula closure and perineal urethrostomy placement were recommended as initial treatment. Also, the possibility of either early female sexual reassignment or phalloplasty were proposed as long-term options for definitive reconstruction. The...

https://ift.tt/2OA91gP

Bilateral primary adrenal lymphoma successfully treated with non-CHOP chemotherapy regimen

Primary bilateral non-Hodgkin's lymphoma of the adrenal gland is a rare presentation with <200 reported cases. We report a 70-year-old man who presented with vomiting and abdominal pain for 2 weeks and was subsequently diagnosed to have high-grade lymphoma of the adrenal glands. The patient was then started on a rituximab–bendamustine chemotherapy regimen. The patient tolerated treatment well without significant side effects. Repeat positron emission tomography CT scan after four cycles of chemotherapy showed complete response. The patient has completed six cycles of chemotherapy and is on regular follow-up with no signs of relapse.

https://ift.tt/2nE5iDK

Issue Information ‐ TOC

International Journal of Osteoarchaeology, Volume 28, Issue 4, Page 375-376, July/August 2018.


https://ift.tt/2MO7unb

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography.

Holmes, N; Leggett, J; Boto, E; Roberts, G; Hill, RM; Tierney, TM; Shah, V; ... Bowtell, R; + view all Holmes, N; Leggett, J; Boto, E; Roberts, G; Hill, RM; Tierney, TM; Shah, V; Barnes, GR; Brookes, MJ; Bowtell, R; - view fewer (2018) A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography. Neuroimage , 181 pp. 760-774. 10.1016/j.neuroimage.2018.07.028 . Green open access

https://ift.tt/2BcfooM

Development of electrophysiological and behavioural measures of electrode discrimination in adult cochlear implant users.

Mathew, R; Vickers, D; Boyle, P; Shaida, A; Selvadurai, D; Jiang, D; Undurraga, J; (2018) Development of electrophysiological and behavioural measures of electrode discrimination in adult cochlear implant users. Hear Res , 367 pp. 74-87. 10.1016/j.heares.2018.07.002 . (In press). Green open access

https://ift.tt/2P33hxc

Functional polymer fibre spinning by infusion gyration

Zhang, Siqi; (2018) Functional polymer fibre spinning by infusion gyration. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2KQxYm6

Person-centred care and HIV: challenges and solutions

Barber, TJ; Saunders, JM; Barnett, N; (2018) Person-centred care and HIV: challenges and solutions. Sexually Transmitted Infections 10.1136/sextrans-2018-053569 . (In press). Green open access

https://ift.tt/2P5NnSJ

Investigating functional and biochemical consequences of p110 delta overactivity in innate immunity

Zarafov, Antonios; (2018) Investigating functional and biochemical consequences of p110 delta overactivity in innate immunity. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2KWXRAQ

Distinct encoding of decision confidence in human medial prefrontal cortex

Bang, D; Fleming, SM; (2018) Distinct encoding of decision confidence in human medial prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America , 115 (23) pp. 6082-6087. 10.1073/pnas.1800795115 .

https://ift.tt/2P5CBvQ

"We're stronger if we work together": Experiences of naturally occurring peer support in an inpatient setting

Galloway, A; Pistrang, N; (2018) "We're stronger if we work together": Experiences of naturally occurring peer support in an inpatient setting. Journal of Mental Health (In press).

https://ift.tt/2KQJb6f

Retinal vasculometry associations with cardiometabolic risk factors in the European Prospective Investigation of Cancer Norfolk study

Owen, CG; Rudnicka, AR; Welikala, RA; Fraz, MM; Barman, SA; Luben, R; Hayat, SA; ... Foster, PJ; + view all Owen, CG; Rudnicka, AR; Welikala, RA; Fraz, MM; Barman, SA; Luben, R; Hayat, SA; Khaw, K-T; Strachan, DP; Whincup, PH; Foster, PJ; - view fewer (2018) Retinal vasculometry associations with cardiometabolic risk factors in the European Prospective Investigation of Cancer Norfolk study. Ophthalmology 10.1016/j.ophtha.2018.07.022 . (In press). Green open access

https://ift.tt/2P7WtOQ

Investigating the effects of pharmacological upregulation of the heat shock response in models of inclusion body myositis

Spicer, Charlotte Jayne; (2018) Investigating the effects of pharmacological upregulation of the heat shock response in models of inclusion body myositis. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2KRizSg

Man vs machine: how good are clinicians at predicting perioperative risk?

Wong, DJN; Sahni, A; Bedford, JR; Harris, SK; Moonesinghe, SR; (2018) Man vs machine: how good are clinicians at predicting perioperative risk? Presented at: BJA Research Forum, London, UK.

https://ift.tt/2P8YWsu

MRI-verified "asleep" deep brain stimulation in Malta through cross border collaboration: clinical outcome of the first five years

Chircop, C; Dingli, N; Aquilina, A; Zrinzo, L; Aquilina, J; (2018) MRI-verified "asleep" deep brain stimulation in Malta through cross border collaboration: clinical outcome of the first five years. British Journal of Neurosurgery 10.1080/02688697.2018.1478061 . (In press).

https://ift.tt/2Bc6Xdi

Emergent Properties of Antiagglomerant Films Control Methane Transport: Implications for Hydrate Management

Sicard, F; Bui, T; Monteiro, D; Lan, Q; Ceglio, M; Burress, C; Striolo, A; (2018) Emergent Properties of Antiagglomerant Films Control Methane Transport: Implications for Hydrate Management. Langmuir 10.1021/acs.langmuir.8b01366 . (In press).

https://ift.tt/2P8YxGu

Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial

Inwald, DP; Canter, R; Woolfall, K; Mouncey, P; Zenasni, Z; O'Hara, C; Carter, A; ... PERUKI (Paediatric Emergency Research in the UK and Ireland) and, ; + view all Inwald, DP; Canter, R; Woolfall, K; Mouncey, P; Zenasni, Z; O'Hara, C; Carter, A; Jones, N; Lyttle, MD; Nadel, S; Peters, MJ; Harrison, DA; Rowan, KM; PERUKI (Paediatric Emergency Research in the UK and Ireland) and, ; - view fewer (2018) Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial. Archives of Disease in Childhood 10.1136/archdischild-2018-314924 . (In press). Green open access

https://ift.tt/2KR85T3

Transcriptional targets of Eph receptor and ephrin signalling in the zebrafish hindbrain

Stanforth, Hannah Amy; (2018) Transcriptional targets of Eph receptor and ephrin signalling in the zebrafish hindbrain. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2P8opSF

Artefacts of Excavation

Stevenson, A; (2017) Artefacts of Excavation. Archaeology International , 20 pp. 58-63. 10.5334/ai.352 . Green open access

https://ift.tt/2KO3Qru

A Bayesian framework for health economic evaluation in studies with missing data.

Mason, AJ; Gomes, M; Grieve, R; Carpenter, JR; (2018) A Bayesian framework for health economic evaluation in studies with missing data. Health Econ 10.1002/hec.3793 . (In press). Green open access

https://ift.tt/2P6TW7J

Negative effects in psychotherapy: commentary and recommendations for future research and clinical practice

Rozental, A; Castonguay, L; Dimidjian, S; Lambert, M; Shafran, R; Andersson, G; Carlbring, P; (2018) Negative effects in psychotherapy: commentary and recommendations for future research and clinical practice. BJPsych Open , 4 (4) pp. 307-312. 10.1192/bjo.2018.42 . Green open access

https://ift.tt/2B7vxMs

Targeting Procrastination Using Psychological Treatments: A Systematic Review and Meta-Analysis

Rozental, A; Bennett, SD; Forsström, D; Ebert, DD; Shafran, R; Andersson, G; Carlbring, P; (2018) Targeting Procrastination Using Psychological Treatments: A Systematic Review and Meta-Analysis. Frontiers in Psychology 10.3389/fpsyg.2018.01588 . (In press).

https://ift.tt/2P9jVv5

Realistic numerical image-based modelling of biological tissue substrates

Sweeney, Paul William; (2018) Realistic numerical image-based modelling of biological tissue substrates. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2BainOz

Mutations in TOP3A Cause a Bloom Syndrome-like Disorder

Martin, C-A; Sarlós, K; Logan, CV; Thakur, RS; Parry, DA; Bizard, AH; Leitch, A; ... Jackson, AP; + view all Martin, C-A; Sarlós, K; Logan, CV; Thakur, RS; Parry, DA; Bizard, AH; Leitch, A; Cleal, L; Ali, NS; Al-Owain, MA; Allen, W; Altmüller, J; Aza-Carmona, M; Barakat, BAY; Barraza-García, J; Begtrup, A; Bogliolo, M; Cho, MT; Cruz-Rojo, J; Dhahrabi, HAM; Elcioglu, NH; GOSgene, ; Gorman, GS; Jobling, R; Kesterton, I; Kishita, Y; Kohda, M; Le Quesne Stabej, P; Malallah, AJ; Nürnberg, P; Ohtake, A; Okazaki, Y; Pujol, R; Ramirez, MJ; Revah-Politi, A; Shimura, M; Stevens, P; Taylor, RW; Turner, L; Williams, H; Wilson, C; Yigit, G; Zahavich, L; Alkuraya, FS; Surralles, J; Iglesais, A; Murayama, K; Wollnik, B; Dattani, M; Heath, KE; Hickson, ID; Jackson, AP; - view fewer (2018) Mutations in TOP3A Cause a Bloom Syndrome-like Disorder. American Journal of Human Genetics , 103 (2) pp. 221-231. 10.1016/j.ajhg.2018.07.001 . Green open access

https://ift.tt/2P1OQcV

Monozygotic twins with group C xeroderma pigmentosum due to a compound heterozygous mutation in XPC gene

The Journal of Dermatology, EarlyView.


https://ift.tt/2B8q5st

Gut microbiota alterations in moderate to severe acne vulgaris patients

The Journal of Dermatology, EarlyView.


https://ift.tt/2vHXi97

Severe thiopurine‐induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case–control study

The Journal of Dermatology, EarlyView.


https://ift.tt/2w6DImm

A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies

Conditions:   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck;   Renal Cell Carcinoma;   Breast Cancer;   Colorectal Cancer;   Melanoma;   Bladder Cancer;   Ovarian Cancer;   Endometrial Cancer;   Merkel Cell Carcinoma;   GastroEsophageal Cancer
Interventions:   Drug: AB154;   Drug: AB122
Sponsor:   Arcus Biosciences, Inc.
Not yet recruiting

https://ift.tt/2P6b9y5

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Conditions:   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck;   Breast Cancer;   Colorectal Cancer;   Melanoma;   Bladder Cancer;   Ovarian Cancer;   Endometrial Cancer;   Merkel Cell Carcinoma;   GastroEsophageal Cancer;   Renal Cell Carcinoma
Interventions:   Drug: AB928;   Drug: AB122
Sponsor:   Arcus Biosciences, Inc.
Recruiting

https://ift.tt/2Ba8jVF

Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

Conditions:   Thyroid Cancer;   Thyroid Cancer, Medullary;   Differentiated Thyroid Cancer;   Papillary Thyroid Cancer;   Follicular Thyroid Cancer;   Poorly Differentiated Thyroid Gland Carcinoma
Interventions:   Drug: Lenvatinib;   Drug: Sorafenib;   Drug: Cabozantinib;   Drug: Vandetanib
Sponsor:   H. Lee Moffitt Cancer Center and Research Institute
Recruiting

https://ift.tt/2P57tNb

Identification of gibberellin‐regulated protein as a new allergen in orange allergy

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nChzZb

Dietary patterns and respiratory health in adults from nine European countries – evidence from the GA2LEN study

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2BbW4rW

Inhibition of H3K27me3 demethylases attenuates asthma by reversing the shift in airway smooth muscle phenotype

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nAmauZ

Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model

The Laryngoscope, EarlyView.


https://ift.tt/2w5dEbm

First Successful Mechanical Splint for Obstructive Sleep Apnea With an Orally Administrable Pharyngeal Stenting Device

The Laryngoscope, EarlyView.


https://ift.tt/2MeazQZ

In Response to Upper Airway Stimulation Therapy and Prior Airway Surgery for Obstructive Sleep Apnea

The Laryngoscope, EarlyView.


https://ift.tt/2w6f5Gf

Upper Airway Stimulation in Patients With Obstructive Sleep Apnea and an Elevated Body Mass Index: A Multi‐institutional Review

The Laryngoscope, EarlyView.


https://ift.tt/2McvBQ1

Trigger Reduction Prior to Systemic Drugs for Neurogenic Chronic Cough

The Laryngoscope, EarlyView.


https://ift.tt/2w9V8OO

The Relationships Between the Nasolacrimal Duct and the Anterior Wall of the Maxillary Sinus

The Laryngoscope, EarlyView.


https://ift.tt/2McvDr7

Clinical Implications of Tumor‐Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma

The Laryngoscope, EarlyView.


https://ift.tt/2MMz4RI

Initial and Long‐term Retention of Robotic Technical Skills in an Otolaryngology Residency Program

The Laryngoscope, EarlyView.


https://ift.tt/2MnwvID

An investigation of left–right vocal fold symmetry in rheological and histological properties

The Laryngoscope, EarlyView.


https://ift.tt/2w9V9Cm

Endonasal anatomy of the olfactory neural network: Surgical implications

The Laryngoscope, EarlyView.


https://ift.tt/2MqRTwL

Automated classification of osteomeatal complex inflammation on computed tomography using convolutional neural networks

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2OB0p9Y

Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2nySvSS

Pathogenic genes related to the progression of actinic keratoses to cutaneous squamous cell carcinoma

International Journal of Dermatology, EarlyView.


https://ift.tt/2KNMxH2

An inside look at prurigo pigmentosa: case report from Ukraine

International Journal of Dermatology, EarlyView.


https://ift.tt/2P8vov1

Sex hormones, erectile dysfunction, and psoriasis; a bad friendship!

International Journal of Dermatology, EarlyView.


https://ift.tt/2w5kqh7

Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split‐face comparative study

International Journal of Dermatology, EarlyView.


https://ift.tt/2Miz7Z6

Lymphedema in patients with hidradenitis suppurativa: a systematic review of published literature

International Journal of Dermatology, EarlyView.


https://ift.tt/2w1Ob2m

Resident experiences with social media: modernizing dermatology training

International Journal of Dermatology, EarlyView.


https://ift.tt/2P8hOrt

Prevalence, risk factors, and mortality outcome in the drug reaction with eosinophilia and systemic symptoms patients with cardiac involvement

International Journal of Dermatology, EarlyView.


https://ift.tt/2KTcHIq

Hemoglobin as an indicator of disease activity in severe hidradenitis suppurativa

International Journal of Dermatology, EarlyView.


https://ift.tt/2MdvW4Q

Pemphigus vulgaris with vegetating feature confined to the scalp

International Journal of Dermatology, EarlyView.


https://ift.tt/2KTcxki

Secondary syphilis presented with impetigo‐like lesions: a rare case report

International Journal of Dermatology, EarlyView.


https://ift.tt/2MgzXWb

Unusual hair findings in a child with cardiofaciocutaneous syndrome

International Journal of Dermatology, EarlyView.


https://ift.tt/2w6fqZz

Euromelanoma in Portugal. How useful was the Euromelanoma campaign between 2010 and 2017?

International Journal of Dermatology, EarlyView.


https://ift.tt/2P1xGMx

Single question burden of disease assessment in patients referred for patch testing

International Journal of Dermatology, EarlyView.


https://ift.tt/2w9V95m

Atezolizumab‐associated vitiligo‐like leukoderma in a patient with transitional cell carcinoma

International Journal of Dermatology, EarlyView.


https://ift.tt/2MhzWRO

Impact of tumour profiling on clinical trials in salivary gland cancer

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2P85w2d

Undergraduate ear, nose and throat training: How do we inspire the next generation? Response to author

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KRZ5Np

Endoscopic approach in one hundred and seventy‐nine patients of dacryocystorhinostomy

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MctYBT

Modified fiberscope‐guided nasogastric tube insertion: Our experience with 23 patients

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2w48A75

A Helpful Technique for Increasing the Size of a Tracheostomy Window in Patients with Calcified or Challenging Tracheas Utilising a Kerrison Punch Forceps

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Met6MV

Radiological Parameters Related to Success of the Round Window Approach in Cochlear Implantation: A retrospective study

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KRYN9h

Editorial Board

Publication date: September 2018

Source: Autoimmunity Reviews, Volume 17, Issue 9

Author(s):

https://ift.tt/2nEuUQW

Comparing childhood-versus adult-onset polyarteritis nodosa. Results from the French Vasculitis Study Group Registry

Publication date: Available online 14 August 2018

Source: Autoimmunity Reviews

Author(s): Michele Iudici, Pierre Quartier, Christian Pagnoux, Etienne Merlin, Christian Agard, Achille Aouba, Pascal Roblot, Pascal Cohen, Benjamin Terrier, Luc Mouthon, Loïc Guillevin, Xavier Puéchal, the French Vasculitis Study Group

Abstract

Objective

To investigate differences between childhood (cPAN)- and adult-onset polyarteritis nodosa (aPAN) patients.

Methods

cPAN patients' clinical findings at onset and outcomes were compared to those of aPAN patients from the French Vasculitis Study Group registry matched for year of enrollment and initial systemic versus cutaneous disease. Their information on medications, disease activity and damage were collected. Kaplan–Meier relapse-free survival curves and the log-rank test were used to analyze cPAN versus aPAN differences for predefined outcomes.

Results

Twenty-one children with systemic and 13 with cutaneous PAN were compared with 84 systemic- and 27 cutaneous-matched aPAN patients. Median follow-up exceeded 5 years for both groups. At study entry, mononeuritis multiplex was less frequent in systemic cPAN than systemic aPAN (P = 0.04), and purpura and myalgias were less frequent in cutaneous cPAN than cutaneous aPAN (P < 0.03). During follow-up, systemic cPAN relapsed more often than matched systemic aPAN (P < 0.0001), while relapse rates were similar for cutaneous disease (P > 0.05). Mostly minor relapses, predominantly involving the skin, occurred in all 4 groups. At last visit, damage accrual was comparable for cPAN and aPAN patients, but fewer systemic cPAN patients were treatment-free (15% versus 42%; P = 0.03). Two (6%) cPAN and 8 (7%) aPAN patients died.

Conclusion

Systemic PAN is equally severe in children and adults and carries a higher risk of relapse. The main cutaneous PAN features seem not to be influenced by age at disease onset.

https://ift.tt/2OADCuL

Are photosensitizing medications associated with increased risk of important erythemal reactions during ultraviolet B phototherapy?

British Journal of Dermatology, EarlyView.


https://ift.tt/2ODIAHp

Tofacitinib in patients with moderate‐to‐severe chronic plaque psoriasis: long‐term safety and efficacy in an open‐label extension study

British Journal of Dermatology, EarlyView.


https://ift.tt/2vJKeA1

Why we continue to use the name Propionibacterium acnes

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ODIob9

Ustekinumab Exposure during Conception and Pregnancy in Patients with Chronic Plaque Psoriasis – a case series of 10 pregnancies

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2vJJZF7

Why a randomised melanoma screening trial may be a good idea

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OzRsxn

Different dermoscopic features of clonal seborrheic keratoses

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2vJJSJH

Folliculotropic Mycosis fungoides associated with GATA2 deficiency: a new skin manifestation

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ODI4cr

Measurement of cytokines, chemokines and association with clinical severity of DM/CADM disease

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nDKQ60

Acne: A Side Effect of Masculinizing Hormonal Therapy in Transgender Patients

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ODHZp9

Laser Treatments in Early Wound Healing Improve Scar Appearance: ‐A Randomized Split‐Wound Trial with Non‐ablative Fractional Laser Exposures versus Untreated Controls

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nCGQ5J

Drug‐free microneedles in the treatment of keloids: a single‐blinded intra‐individual controlled clinical trial

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Oua9T6

The frequency of specific contact allergies is reduced in psoriasis patients

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nDL4Ko

An ex‐vivo RNA trans‐splicing strategy to correct human generalized severe epidermolysis bullosa simplex

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OBRK73

Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25‐hydroxyvitamin D3, after a summer holiday in Northern Europe

British Journal of Dermatology, EarlyView.


https://ift.tt/2nDKkF6

Infectious events and associated risk factors in Mycosis Fungoides/Sézary Syndrome: a retrospective cohort study

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OCFUtv

Use of topical antipsoriatic drugs in Denmark: A nationwide drug utilization study

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2vJJ4EF

Outcomes in thread lift for face and neck: A study performed with Silhouette Soft and Promo Happy Lift double needle, innovative and classic techniques

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2vEVSfk

Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2B4PYJP

Quality of life before and after cosmetic procedures on the face: A cross‐sectional study in a public service

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2Miv4vS

The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2w7Jl3F

Sparing subcutaneous septa avoids skin necrosis in the treatment of axillary bromhidrosis with suction‐curettage shaving

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2vInaBB

Das hepatozelluläre Karzinom – pathologische und molekularpathologische Diagnostik

Zusammenfassung

Hintergrund

Das hepatozelluläre Karzinom (HCC) ist histopathologisch definiert. Histo- und molekularpathologische Diagnostikverfahren sind Grundlage einer stadiengerechten Therapie, aber auch therapeutischer Innovation. Basierend auf klassischen histologischen Charakteristika wurden in den letzten Jahren vielfältige Verbesserungen hin zu einer modernen, morphomolekularen Diagnostik des HCC erreicht: multiple neue Marker zur Präzisierung der Differenzial- und insbesondere Malignitätsdiagnose bei hochdifferenzierten Lebertumoren; Definition neuer tumorbiologisch definierter und relevanter HCC-Subtypen, die bis zu 30 % der HCC betreffen; molekulare Zielstrukturen und potenzielle prädiktive Marker für präzisionsonkologische Ansätze. Dies sind Bausteine einer neuen morphomolekularen Klassifikation des HCC, die eine wesentliche zukünftige Herausforderung darstellt.

Künftige Anforderungen

Es muss nicht nur eine neue morphomolekulare Klassifikation erstellt werden, sondern auch die Position der Biopsiediagnostik des HCC bedarf einer grundlegenden Verbesserung. Zudem müssen neue immunonkologische Ansätze diagnostisch sinnvoll untermauert werden und die neuen Erkenntnisse in entsprechend geplanten Studien und auch geeigneten zentrenbasierten Ansätzen diagnostisch und klinisch umgesetzt werden, um die in Bezug auf andere relevante Tumorarten immer noch unbefriedigende klinische Position des HCC nachhaltig zu verbessern.

https://ift.tt/2vIG7UO

Decreased gastrostomy tube incidence and weight loss after transoral robotic surgery for low‐ to intermediate‐risk oropharyngeal squamous cell carcinoma

Head &Neck, EarlyView.


https://ift.tt/2Mc74ut

Adverse pathologic features in T1/2 oral squamous cell carcinoma classified by the American Joint Committee on Cancer eighth edition and implications for treatment

Head &Neck, EarlyView.


https://ift.tt/2KQDUeM

Stent grafts in patients with carotid blowout syndrome: Outcome and antiplatelet therapy in preventive versus emergency cases

Head &Neck, EarlyView.


https://ift.tt/2P9CSy2

Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation

Head &Neck, EarlyView.


https://ift.tt/2wejpnd

Antiproliferative potential of miR‐33a in laryngeal cancer Hep‐2 cells via targeting PIM1

Head &Neck, EarlyView.


https://ift.tt/2P8ZvTd

Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: A meta‐analysis

Head &Neck, EarlyView.


https://ift.tt/2w7Jggn

Analysis of readmissions after transoral robotic surgery for oropharyngeal squamous cell carcinoma

Head &Neck, EarlyView.


https://ift.tt/2Mj7yPC

Predictors of graft function after parathyroid autotransplantation during thyroid surgery

Head &Neck, EarlyView.


https://ift.tt/2w5x8fO

Psoriasis dermatitis: an overlap condition of psoriasis and atopic dermatitis in children

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nza8Ca

PUVA and interferon‐α2b combined therapy for patients with mycosis fungoides at different stages of the disease: a seven‐year retrospective study in Russia

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OAcvjH

Reply to: “S2k guideline for treatment of cutaneous lupus erythematosus ‐ guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)”

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2P4Wof3

Role of Galectin‐3 in subclinical myocardial impairment in psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Ozp92g

Reply to the letter by Pindado‐Ortega et al

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nBAIKX

Chemotherapy‐induced alopecia ‐ the urgent need for treatment options

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2B73Y5C

ΜelanoQ: A Consensus Questionnaire of Standardized Epidemiologic and Clinical Variables for Melanoma Risk Assessment by the MelaNostrum Consortium

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nDJzMg

TIPE2 sensitizes osteosarcoma cells to cis-platin by down-regulating MDR1 via the TAK1- NF-κB and - AP-1 pathways

Publication date: September 2018

Source: Molecular Immunology, Volume 101

Author(s): Peiqing Zhao, Sujie Wang, Jie Jiang, Hong Liu, Xiaolan Zhu, Ning Zhao, Jigang Li, Yingchun Yin, Xiaoyan Pan, Xiuzhen Yang, Jianping Guo, Wenlin Xu

Abstract

TIPE2 participates in multiple types of cancer development. However, its mechanism underlying chemoresistance in osteosarcoma has not been elucidated. Herein, we observed the expression of TIPE2 and MDR1 in cis-platin-resistant osteosarcoma tissues and cell lines. Compared to their matched sensitive cell lines and tissues, TIPE2 was downregulated while MDR1 expression was increased. Further investigation showed that overexpression of TIPE2 effectively inhibited MDR1 expression and greatly sensitized osteosarcoma cells to cis-platin, both in vivo and in vitro. Mechanistically, TIPE2 inhibited the transcription of the MDR1 promoter by interfering with the TAK1-NF-κB and -AP-1 pathways. Overall, our results elucidated for the first time that TIPE2 sensitizes osteosarcoma cells to cis-platin through downregulation of MDR1 and may be a novel target in osteosarcoma therapy.

https://ift.tt/2KTc8yb

['A Work from an Unknown Member of the Proletariat': ] Digitising and Re-examining Vere Gordon Childe's 'Dawn of European Civilization': a celebration of the UCL Institute of Archaeology's 80th Anniversary

Meheux, KL; (2017) ['A Work from an Unknown Member of the Proletariat': ] Digitising and Re-examining Vere Gordon Childe's 'Dawn of European Civilization': a celebration of the UCL Institute of Archaeology's 80th Anniversary. Archaeology International , 20 pp. 91-105. 10.5334/ai.357 . Green open access

https://ift.tt/2P8m7mH

The Building Bridges Research Project at the London Science Museum: Using an Ethnographic Approach with Under-Represented Visitor Groups

Haywood, N; Moussouri, T; (2017) The Building Bridges Research Project at the London Science Museum: Using an Ethnographic Approach with Under-Represented Visitor Groups. Archaeology International , 20 pp. 69-73. 10.5334/ai-356 . Green open access

https://ift.tt/2KRnToT

Human niche construction and population growth in pre-Columbian Amazonia

Arroyo-Kalin, M; (2018) Human niche construction and population growth in pre-Columbian Amazonia. Archaeology International , 20 pp. 122-136. 10.5334/ai.367 . Green open access

https://ift.tt/2P6JBZm

Detection of Chlamydia trachomatis in rectal specimens in women and its association with anal intercourse: a systematic review and meta-analysis

Chandra, NL; Broad, C; Folkard, K; Town, K; Harding-Esch, EM; Woodhall, SC; Saunders, JM; ... Dunbar, JK; + view all Chandra, NL; Broad, C; Folkard, K; Town, K; Harding-Esch, EM; Woodhall, SC; Saunders, JM; Sadiq, ST; Dunbar, JK; - view fewer (2018) Detection of Chlamydia trachomatis in rectal specimens in women and its association with anal intercourse: a systematic review and meta-analysis. Sexually Transmitted Infections , 94 (5) pp. 320-326. 10.1136/sextrans-2017-053161 . Green open access

https://ift.tt/2Ou47Ss

Cost-effectiveness of microscopy of urethral smears for asymptomatic Mycoplasma genitalium urethritis in men in England

Sutton, AJ; Roberts, TE; Jackson, L; Saunders, J; White, PJ; Birger, R; Estcourt, C; (2018) Cost-effectiveness of microscopy of urethral smears for asymptomatic Mycoplasma genitalium urethritis in men in England. International Journal of STD & AIDS , 29 (1) pp. 72-79. 10.1177/0956462417717651 . Green open access

https://ift.tt/2vJ5Ht0

Novel Strategies in NBIA: A Gene Therapy Approach for PLA2G6-Associated Neurodegeneration

Whaler, Sammie; (2018) Novel Strategies in NBIA: A Gene Therapy Approach for PLA2G6-Associated Neurodegeneration. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2KT71hL

The role of treatment beliefs in the placebo effect

Watkinson, Andrew; (2018) The role of treatment beliefs in the placebo effect. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2P5oczH

Sustainable use of materials in the global paper life cycle

Van Ewijk, Stijn; (2018) Sustainable use of materials in the global paper life cycle. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2ODDWsX

The role of environmental factors in allergy: A critical reappraisal

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MlWjVv

Differential Expression of lncRNAs and predicted target genes in normal mouse melanocytes and B16 cells

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MKvwiT

Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair anagen in mice

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MlWd05

Peptide nucleic acid‐probe based analysis to detect filaggrin mutations in atopic dermatitis patients

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MKYhvy

MAP4 regulates Tctex‐1 and promotes the migration of epidermal cells in hypoxia

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MiOOPp

Functional characterization of the extranasal OR2A4/7 expressed in human melanocytes

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MNnjul

MRGPRX2 is negatively targeted by SCF and IL‐4 to diminish pseudo‐allergic stimulation of skin mast cells in culture

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MlVMTv

LGI3 promotes human keratinocyte differentiation via the Akt pathway

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MNn02F

Development and characterization of DNAzyme candidates demonstrating significant efficiency against human rhinoviruses

Publication date: Available online 14 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Daniel P. Potaczek, Sebastian D. Unger, Nan Zhang, Styliani Taka, Sven Michel, Nesibe Akdağ, Feng Lan, Markus Helfer, Christoph Hudemann, Markus Eickmann, Chrysanthi Skevaki, Spyridon Megremis, Anne Sadewasser, Bilal Alashkar Alhamwe, Fahd Alhamdan, Mübeccel Akdis, Michael R. Edwards, Sebastian L. Johnston, Cezmi A. Akdis, Stephan Becker

Abstract

Background

Infections with human rhinoviruses (RVs) are responsible for millions of common cold episodes and the majority of asthma exacerbations, especially in childhood. No drugs specifically targeting RVs are available.

Objective

To identify specific anti-rhinoviral molecules based on DNAzyme technology as candidates to a clinical study.

Methods

A total of 226 candidate DNAzymes were designed against two regions of RV RNA genome identified to be sufficiently highly conserved between virus strains, i.e. 5'-untranslated (5'-UTR) and cis-acting replication element (CRE), by use of three test strains, RVA1, -A16, and -A29. All DNAzymes were screened for their cleavage efficiency against in vitro-expressed viral RNA. Those showing any catalytic activity were subjected to bioinformatic analysis of their reverse complementarity to 322 published rhinoviral genomic sequences. Further molecular optimization was conducted for most promising candidates. Cytotoxic and off-target effects were excluded in HEK293-cell-based systems. Antiviral efficiency was analyzed in infected human bronchial BEAS-2B cells and ex vivo-cultured human sinonasal tissue.

Results

Screening phase generated DNAzymes characterized by either good catalytic activity or by high RV strain coverage but no single molecule represented a satisfactory combination of those two features. Modifications in length of the binding domains of two lead candidates, Dua-01(-L12R9) and Dua-02(-L10R11), improved their cleavage efficiency to an excellent level with no loss in eminent strain coverage (about 98%). Both DNAzymes showed highly favorable cytotoxic/off-target profiles. Subsequent testing of Dua-01-L12R9 in BEAS-2B cells and sinonasal tissue demonstrated its significant antiviral efficiency.

Conclusions

Effective and specific management of RV infections with Dua-01-L12R9 might be useful in preventing asthma exacerbations, which should be verified by clinical trials.

Graphical abstract

https://ift.tt/2vHFzP4

School-Supervised Use of a Once-Daily Inhaled Corticosteroid Regimen: A Cluster Randomized Trial

Publication date: Available online 14 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Joe K. Gerald, Julia M. Fisher, Mark A. Brown, Conrad J. Clemens, Melissa A. Moore, Scott C. Carvajal, Donna Bryson, Nikki Stefan, Dean Billheimer, Lynn B. Gerald

Background

School-supervised use of a once-daily inhaled corticosteroid regimen (supervised therapy) can improve medication adherence and asthma control.

Objective

To evaluate the effectiveness of supervised therapy in a unique setting and population.

Methods

We conducted a cluster-randomized trial of supervised therapy in 20 elementary schools with a disproportionate enrollment of low income Latino students. Schools were purposively selected, matched, and randomized to receive 9-months of supervised therapy with mometasone furoate or usual care. All English- or Spanish-speaking students with self-reported asthma were eligible. The Asthma Control Questionnaire (ACQ) was interviewer-administered quarterly at school. Students in supervised therapy schools were hypothesized to have lower ACQ scores than students in usual care schools.

Results

Of 393 enrolled students, 189 immediate intervention and 143 delayed intervention students provided ≥1 ACQ data point, were between 6 - 10 years of age, and were included in the primary analysis. At baseline, 39% of students reported taking a controller medication and 24% had well-controlled asthma. Eighty percent of immediate intervention students were prescribed mometasone. Schools administered 98% of prescribed doses when students attended school. Absences, weekends, and holidays reduced calendar adherence to 53%. During the first year, the mean ACQ score for immediate and delayed intervention students was 1.55 (95% CI 1.41, 1.70) and 1.64 (95% CI 1.47, 1.80), respectively. The estimated treatment effect was -0.08 (95% CI -0.31, 0.14).

Discussion

Compared to usual care, supervised therapy did not improve asthma control among this population of Latino students. Additional research is warranted to confirm these results.

Graphical abstract

https://ift.tt/2Ba4vnx

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

Abstract

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

https://ift.tt/2MH109y

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

Abstract

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

https://ift.tt/2MH109y

A Contemporary Perspective on the Management of Post-Craniotomy Headache and Pain

Abstract

Purpose of Review

This article discusses the etiology and management of post-craniotomy headache and pain. A review of available as well as investigatory treatment modalities is offered, followed by suggestions for optimal management of post-craniotomy headache.

Recent Findings

There is a dearth of evidence-based practice regarding the differential diagnosis, natural history, and management of post-craniotomy headache. The etiology of post-craniotomy headache is typically multifactorial, with patients' medical history, type of craniotomy, and perioperative management all playing a role. Post-craniotomy headaches are often undertreated, yet available evidence supports a multimodal approach for both prophylaxis and management. Many therapeutic techniques that aim to treat or prevent post-craniotomy headache require more robust validation than clinical evidence currently imparts. Pre- and intraoperative locoregional anesthesia should be the mainstay of prophylaxis; the role of opiates co-administered with analgesics, corticosteroids, and antiepileptic therapy in the acute perioperative phase is of paramount importance. Treatment of chronic PCH is less well-defined but should involve trials of analgesic, antineuropathic, and antiepileptic medications before enlisting experimental treatments. Comorbid psychiatric, musculoskeletal, or seizure disorders should be managed distinctly from post-craniotomy headaches. In patients failing all extant therapies, experimental approaches should be considered. These include subanesthetic ketamine infusion or surgical site injection with local anesthetics, corticosteroids, or botulinum toxin.

Summary

Post-craniotomy headache is a complex phenomenon with many underutilized treatment options available, and many more under investigation. Nonetheless, further research is required to differentiate the efficacy of contemporary treatment strategies and to elucidate the applicability of novel therapies.

https://ift.tt/2vGayuU

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

Abstract

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

https://ift.tt/2MH109y

Erratum zu: Update zur systemischen Therapie bei fortgeschrittenem hepatozellulärem Karzinom

Erratum zu:

Der Onkologe 2018

https://ift.tt/2MolCpT

Im Abschnitt zur Zweitlinientherapie mit „Ramucirumab" muss es korrekt heißen, dass in der anhand des AFP-Werts vorselektionierten Patientenpopulation eine signifikante Verbesserung des Überlebens erreicht werden konnte. Der …

https://ift.tt/2KSaFYS

Automated Quantitative Computed Tomography Versus Visual Computed Tomography Scoring in Idiopathic Pulmonary Fibrosis: Validation Against Pulmonary Function

Jacob, J; Bartholmai, BJ; Rajagopalan, S; Kokosi, M; Nair, A; Karwoski, R; Raghunath, SM; ... Hansell, DM; + view all Jacob, J; Bartholmai, BJ; Rajagopalan, S; Kokosi, M; Nair, A; Karwoski, R; Raghunath, SM; Walsh, SLF; Wells, AU; Hansell, DM; - view fewer (2016) Automated Quantitative Computed Tomography Versus Visual Computed Tomography Scoring in Idiopathic Pulmonary Fibrosis: Validation Against Pulmonary Function. Journal of Thoracic Imaging , 31 (5) pp. 304-311. 10.1097/RTI.0000000000000220 . Green open access

https://ift.tt/2P8v5jE

Serial automated quantitative CT analysis in idiopathic pulmonary fibrosis: functional correlations and comparison with changes in visual CT scores

Jacob, J; Bartholmai, BJ; Rajagopalan, S; Kokosi, M; Egashira, R; Brun, AL; Nair, A; ... Wells, AU; + view all Jacob, J; Bartholmai, BJ; Rajagopalan, S; Kokosi, M; Egashira, R; Brun, AL; Nair, A; Walsh, SLF; Karwoski, R; Wells, AU; - view fewer (2018) Serial automated quantitative CT analysis in idiopathic pulmonary fibrosis: functional correlations and comparison with changes in visual CT scores. European Radiology , 28 (3) pp. 1318-1327. 10.1007/s00330-017-5053-z .

https://ift.tt/2MHXeMY

Fibrotic Hypersensitivity Pneumonitis: Key Issues in Diagnosis and Management

Kouranos, V; Jacob, J; Nicholson, A; Renzoni, E; (2017) Fibrotic Hypersensitivity Pneumonitis: Key Issues in Diagnosis and Management. Journal of Clinical Medicine , 6 (6) , Article 62. 10.3390/jcm6060062 . Green open access

https://ift.tt/2MoZsUv

Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis

Nolan, CM; Maddocks, M; Maher, TM; Canavan, JL; Jones, SE; Barker, RE; Patel, S; ... Man, WDC; + view all Nolan, CM; Maddocks, M; Maher, TM; Canavan, JL; Jones, SE; Barker, RE; Patel, S; Jacob, J; Cullinan, P; Man, WDC; - view fewer (2018) Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis. Respirology , 23 (5) pp. 498-506. 10.1111/resp.13213 .

https://ift.tt/2MKb41q

Evaluating the impact of the DREAMS partnership to reduce HIV incidence among adolescent girls and young women in four settings: a study protocol

Birdthistle, I; Schaffnit, SB; Kwaro, D; Shahmanesh, M; Ziraba, A; Kabiru, CW; Phillips-Howard, P; ... Floyd, S; + view all Birdthistle, I; Schaffnit, SB; Kwaro, D; Shahmanesh, M; Ziraba, A; Kabiru, CW; Phillips-Howard, P; Chimbindi, N; Ondeng'e, K; Gourlay, A; Cowan, FM; Hargreaves, JR; Hensen, B; Chiyaka, T; Glynn, JR; Floyd, S; - view fewer (2018) Evaluating the impact of the DREAMS partnership to reduce HIV incidence among adolescent girls and young women in four settings: a study protocol. BMC Public Health , 18 , Article 912. 10.1186/s12889-018-5789-7 . Green open access

https://ift.tt/2MjD2nR

Participatory Women's Groups with Cash Transfers Can Increase Dietary Diversity and Micronutrient Adequacy during Pregnancy, whereas Women's Groups with Food Transfers Can Increase Equity in Intrahousehold Energy Allocation

Harris-Fry, HA; Paudel, P; Harrisson, T; Shrestha, N; Jha, S; Beard, BJ; Copas, A; ... Saville, NM; + view all Harris-Fry, HA; Paudel, P; Harrisson, T; Shrestha, N; Jha, S; Beard, BJ; Copas, A; Shrestha, BP; Manandhar, DS; Costello, AMDL; Cortina-Borja, M; Saville, NM; - view fewer (2018) Participatory Women's Groups with Cash Transfers Can Increase Dietary Diversity and Micronutrient Adequacy during Pregnancy, whereas Women's Groups with Food Transfers Can Increase Equity in Intrahousehold Energy Allocation. The Journal of Nutrition 10.1093/jn/nxy109 . (In press). Green open access

https://ift.tt/2KReI7L

Guided self-help for mental health disorders in children and young people with chronic neurological conditions: A qualitative evaluation

Bennett, SD; Coughtrey, AE; Heyman, I; Greally, S; Clarkson, H; Bhattacharyya, T; Lewis, C; ... Shafran, R; + view all Bennett, SD; Coughtrey, AE; Heyman, I; Greally, S; Clarkson, H; Bhattacharyya, T; Lewis, C; Varadkar, S; Shafran, R; - view fewer (2018) Guided self-help for mental health disorders in children and young people with chronic neurological conditions: A qualitative evaluation. European Journal of Paediatric Neurology , 22 (4) pp. 620-631. 10.1016/j.ejpn.2018.02.011 .

https://ift.tt/2P8uGh8

Influence of sulfur on the fate of heavy metals during clinkerization

Zhang, B; Bogush, A; Wei, J; Zhang, T; Xu, W; Yu, Q; (2018) Influence of sulfur on the fate of heavy metals during clinkerization. Construction and Building Materials , 182 pp. 144-155. 10.1016/j.conbuildmat.2018.06.084 .

https://ift.tt/2KQHW6X

Taking rumours seriously: Why organ thieves matter to malaria control

Iskander, D; (2017) Taking rumours seriously: Why organ thieves matter to malaria control. Anthropology Today , 33 (4) pp. 9-12. 10.1111/1467-8322.12360 . Green open access

https://ift.tt/2MjCQVF

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

Grassmann, F; Kiel, C; Zimmermann, ME; Gorski, M; Grassmann, V; Stark, K; Heid, IM; Grassmann, F; Kiel, C; Zimmermann, ME; Gorski, M; Grassmann, V; Stark, K; Heid, IM; Weber, BHF; - view fewer (2017) Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Medicine , 9 , Article 29. 10.1186/s13073-017-0418-0 . Green open access

https://ift.tt/2MILoCq

Non-destructive structural imaging of steelwork with atomic magnetometers

Bevington, P; Gartman, R; Chalupczak, W; Deans, C; Marmugi, L; Renzoni, F; Non-destructive structural imaging of steelwork with atomic magnetometers. [Letter]. Appl. Phys. Lett. , 113 , Article 063503. 10.1063/1.5042033 . Green open access

https://ift.tt/2P7D8gP

An innovative strategy for the molecular diagnosis of Usher syndrome identifies causal biallelic mutations in 93% of European patients

Bonnet, C; Riahi, Z; Chantot-Bastaraud, S; Smagghe, L; Letexier, M; Marcaillou, C; Lefevre, GM; ... Petit, C; + view all Bonnet, C; Riahi, Z; Chantot-Bastaraud, S; Smagghe, L; Letexier, M; Marcaillou, C; Lefevre, GM; Hardelin, J-P; El-Amraoui, A; Singh-Estivalet, A; Mohand-Said, S; Kohl, S; Kurtenbach, A; Sliesoraityte, I; Zobor, D; Gherbi, S; Testa, F; Simonelli, F; Banfi, S; Fakin, A; Glavac, D; Jarc-Vidmar, M; Zupan, A; Battelino, S; Martorell Sampol, L; Antonia Claveria, M; Catala Mora, J; Dad, S; Moller, LB; Rodriguez Jorge, J; Hawlina, M; Auricchio, A; Sahel, J-A; Marlin, S; Zrenner, E; Audo, I; Petit, C; - view fewer (2016) An innovative strategy for the molecular diagnosis of Usher syndrome identifies causal biallelic mutations in 93% of European patients. European Journal of Human Genetics , 24 (12) pp. 1730-1738. 10.1038/ejhg.2016.99 . Green open access

https://ift.tt/2MGd0Ib

Opportunities for system level improvement in antibiotic use across the surgical pathway

Charani, E; Ahmad, R; Tarrant, C; Birgand, G; Leather, A; Mendelson, M; Moonesinghe, SR; ... Holmes, A; + view all Charani, E; Ahmad, R; Tarrant, C; Birgand, G; Leather, A; Mendelson, M; Moonesinghe, SR; Sevdalis, N; Singh, S; Holmes, A; - view fewer (2017) Opportunities for system level improvement in antibiotic use across the surgical pathway. International Journal of Infectious Diseases , 60 pp. 29-34. 10.1016/j.ijid.2017.04.020 . Green open access

https://ift.tt/2MqjPRs

Experiences of outcome monitoring in service users with psychosis: Findings from an Improving Access to Psychological Therapies for people with Severe Mental Illness (IAPT-SMI) demonstration site

Fornells-Ambrojo, M; Johns, L; Onwumere, J; Garety, P; Milosh, C; Iredale, C; Peters, E; ... Jolley, S; + view all Fornells-Ambrojo, M; Johns, L; Onwumere, J; Garety, P; Milosh, C; Iredale, C; Peters, E; Webster, A; Jolley, S; - view fewer (2017) Experiences of outcome monitoring in service users with psychosis: Findings from an Improving Access to Psychological Therapies for people with Severe Mental Illness (IAPT-SMI) demonstration site. British Journal of Clinical Psychology , 56 (3) pp. 253-272. 10.1111/bjc.12136 . Green open access

https://ift.tt/2MGcNET

Deconstructing sociotechnical identity in maker cultures

Marshall, A; Rode, J; (2018) Deconstructing sociotechnical identity in maker cultures. In: Proceedings of the 4th Conference on Gender & IT. (pp. pp. 91-100). ACM Green open access

https://ift.tt/2P7EEQ6

Computational making, binary gender and LEGO

Rode, JA; Cucuiat, V; (2018) Computational making, binary gender and LEGO. In: GenderIT '18 Proceedings of the 4th Conference on Gender & IT. (pp. pp. 35-42). ACM Green open access

https://ift.tt/2KRe4XT

Diagnosing Light Chain Amyloidosis on Temporal Artery Biopsies for Suspected Giant Cell Arteritis

Ghinai, RAM; Mahmood, S; Mukonoweshuro, P; Webber, S; Wechalekar, AD; Moore, SE; (2017) Diagnosing Light Chain Amyloidosis on Temporal Artery Biopsies for Suspected Giant Cell Arteritis. Journal of Neuro-Ophthalmology , 37 (1) pp. 34-39. 10.1097/WNO.0000000000000447 . Green open access

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Radiofrequency ablation compared with argon plasma coagulation after endoscopic resection of high-grade dysplasia or T1 adenocarcinoma in Barrett's esophagus: a randomized pilot study (BRIDE).

Peerally, MF; Bhandari, P; Ragunath, K; Barr, H; Haidry, R; Lovat, L; Smart, H; ... de Caestecker, JS; + view all Peerally, MF; Bhandari, P; Ragunath, K; Barr, H; Haidry, R; Lovat, L; Smart, H; Harrison, R; Stokes, C; Smith, K; Morris, T; de Caestecker, JS; - view fewer (2018) Radiofrequency ablation compared with argon plasma coagulation after endoscopic resection of high-grade dysplasia or T1 adenocarcinoma in Barrett's esophagus: a randomized pilot study (BRIDE). Gastrointestinal Endoscopy 10.1016/j.gie.2018.07.031 . (In press).

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Management of non-variceal upper gastrointestinal bleeding: Where are we in 2018?

Alzoubaidi, D; Lovat, LB; Haidry, R; (2018) Management of non-variceal upper gastrointestinal bleeding: Where are we in 2018? Frontline Gastroenterology 10.1136/flgastro-2017-100901 . (In press). Green open access

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Russia and the international struggle around Afghanistan 2001-2012: competition and co-operation in historical perspective

Sangar, Kanshko; (2018) Russia and the international struggle around Afghanistan 2001-2012: competition and co-operation in historical perspective. Doctoral thesis (Ph.D), UCL (University College London).

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