Resting state and cognitive vulnerability to depression : a neurocognitive investigation

http://ift.tt/2qN74D2

Immune response against Giardia duodenalis infection in cattle

Giardia duodenalis is een belangrijke parasiet bij mensen en dieren. In runderen kan G. duodenalis diarree en gewichtsverlies veroorzaken en infecties zijn meestal chronisch. Dit suggereert dat Giardia in staat is om het immuunsysteem van de gastheer te onderdrukken of te ontwijken. Met uitzondering van G. duodenalis en G. muris in het muis-model, is de kennis over de immuniteit tegen Giardia beperkt. Daarom is de doelstelling van deze thesis om de immuunrespons tegen G. duodenalis te onderzoeken in runderen en om potentiele mechanismen te identificeren die zorgen voor het chronische verloop van giardiosis in de natuurlijke gastheer. In muizen onderdrukt G. duodenalis de respons van dendritische cellen (DC) op stimulatie van de Toll-like receptor liganden. Dit suggereert dat G. duodenalis een immuun-modulerend effect heeft op DC. Daarom werd in het eerste deel van deze thesis het effect van G. duodenalis onderzocht op DCs, afkomstig van monocyten van het rund (MoDC). Ook werd nagegaan of de parasiet in staat is om via MoDC verdere adaptieve immuunresponsen te induceren en te beïnvloeden. De maturatie en cytokineproductie van runder-MoDC na incubatie met G. duodenalis werd onderzocht, alsook de capaciteit van Giardia-gestimuleerde MoDC om lymfocytproliferatie te induceren. MoDC gestimuleerd met G. duodenalis waren functioneel actief en in staat om proliferatie van T-cellen te induceren, die zowel pro- als anti-inflammatoire cytokines produceren. G. duodenalis was niet in staat om de respons van de MoDC na stimulatie van TLR4 door LPS, te beïnvloeden. Er werd geen bewijs gevonden dat G. duodenalis een regulerend of inhiberend effect heeft op runder MoDC. In het tweede deel van deze thesis werd de kinetiek van de immuunrespons tegen G. duodenalis onderzocht in runderen, om het mechanisme te identificeren dat het chronische karakter van G. duodenalis infecties in runderen kan verklaren. Zes kalveren werden experimenteel geïnfecteerd met G. duodenalis, waarna de cysten-excretie, de kinetiek van de circulerende geheugencellen en van serum-antilichamen werd gevolgd. De cysten-excretie startte een week na de infectie en bleef hoog tot week 14, waarna een continue lage uitscheiding aangaf dat de dieren immuniteit ontwikkeld hadden. Vijf weken na de start van de infectie werd een significante proliferatie van CD4+ αβ T-cellen in het bloed gemeten. Tijdens de piek van de proliferatie werd door deze cellen vooral IL-17 tot expressie gebracht. Serum concentraties van anti-G. duodenalis IgG1 en IgA stegen significant vanaf week 11. Serum antilichamen waren vanaf de start van de infectie gericht tegen alle variant-specifieke oppervlakte eiwitten (vsp) en niet enkel tegen bepaalde subpopulaties. Dit duidt er op dat bescherming tegen G. duodenalis niet alleen gebaseerd is op de herkenning van alle vsp door antilichamen, maar ook op de antilichaamconcentratie. Deze data wijzen erop dat de immuun-respons in runderen tegen G. duodenalis traag verloopt en waarschijnlijk onderdrukt wordt door een nog onbekend mechanisme. Toekomstig onderzoek zal moeten gericht zijn op de inductie van een IL-17 respons, die mogelijk geassocieerd is met protectie.

http://ift.tt/2q1bOrJ

In the beginning was the act: a historical and systematic analysis of Hermann von Helmholtz's psychology of the object

http://ift.tt/2qNax4I

Prepubertal gonadectomy in shelter cats : anaesthesia, surgery and effect of age at time of gonadectomy on health and behaviour

In Belgium, prepubertal gonadectomy (PPG), defined as gonadectomy well before sexual maturity, is not yet routinely performed in cats. Notwithstanding a number of experimental and clinical studies in the United States of America and the United Kingdom about early age neutering, timing of gonadectomy remains controversial. The objections from veterinarians raised against PPG pertain to animal health and welfare and can be summarized as concerns regarding technical challenges, issues of safety during anaesthesia and surgery, and possible short- and long-term complications on health and behaviour. To better understand the feasibility of PPG and to document short- and long-term effects on health and well-being of cats undergoing early age neutering, the Federal Public Service Health, Food Chain Safety and Environment funded a large-scale project in shelter cats. For PPG to be fully accepted by the lay and veterinary community, the anaesthetic and surgical procedures should be as safe and efficient as those used for gonadectomy at traditional age (TAG). Moreover, health and behaviour issues should not be more common among PPG cats compared to TAG cats. The aims of this doctoral dissertation were three-fold: (1) to describe safe and efficient anaesthetic and surgical protocols to perform PPG and to compare those with TAG, (2) to investigate the relationship between age at gonadectomy and short- and long-term health issues in adopted shelter kittens (until 24 months of age), and (3) to assess short- and long-term effects of PPG on the behaviour in shelter cats (until 24 months after adoption). In this study, 800 shelter kittens were recruited and randomly assigned to two treatment groups using unequal group sizes: 2/3 PPG, between 8 to 12 weeks of age (0.7 to 1.4 kg), and 1/3 TAG, between 6 to 8 months of age.

http://ift.tt/2q0IcLf

EEG activity as an objective measure of cognitive load during effortful listening: A study on pediatric subjects with bilateral, asymmetric sensorineural hearing loss

Publication date: August 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 99
Author(s): Pasquale Marsella, Alessandro Scorpecci, Giulia Cartocci, Sara Giannantonio, Anton Giulio Maglione, Isotta Venuti, Ambra Brizi, Fabio Babiloni
ObjectivesDeaf subjects with hearing aids or cochlear implants generally find it challenging to understand speech in noisy environments where a great deal of listening effort and cognitive load are invested. In prelingually deaf children, such difficulties may have detrimental consequences on the learning process and, later in life, on academic performance. Despite the importance of such a topic, currently, there is no validated test for the assessment of cognitive load during audiological tasks. Recently, alpha and theta EEG rhythm variations in the parietal and frontal areas, respectively, have been used as indicators of cognitive load in adult subjects.The aim of the present study was to investigate, by means of EEG, the cognitive load of pediatric subjects affected by asymmetric sensorineural hearing loss as they were engaged in a speech-in-noise identification task.MethodsSeven children (4F and 3M, age range = 8–16 years) affected by asymmetric sensorineural hearing loss (i.e. profound degree on one side, mild-to-severe degree on the other side) and using a hearing aid only in their better ear, were included in the study. All of them underwent EEG recording during a speech-in-noise identification task: the experimental conditions were quiet, binaural noise, noise to the better hearing ear and noise to the poorer hearing ear. The subjects' Speech Recognition Thresholds (SRT) were also measured in each test condition. The primary outcome measures were: frontal EEG Power Spectral Density (PSD) in the theta band and parietal EEG PSD in the alpha band, as assessed before stimulus (word) onset.ResultsNo statistically significant differences were noted among frontal theta power levels in the four test conditions. However, parietal alpha power levels were significantly higher in the "binaural noise" and in the "noise to worse hearing ear" conditions than in the "quiet" and "noise to better hearing ear" conditions (p < 0.001). SRT scores were consistent with task difficulty, but did not correlate with alpha and theta power level variations.ConclusionThis is the first time that EEG has been applied to children with sensorineural hearing loss with the purpose of studying the cognitive load during effortful listening. Significantly higher parietal alpha power levels in two of three noisy conditions, compared to the quiet condition, are consistent with increased cognitive load. Specifically, considering the time window of the analysis (pre-stimulus), parietal alpha power levels may be a measure of cognitive functions such as sustained attention and selective inhibition. In this respect, the significantly lower parietal alpha power levels in the most challenging listening condition (i.e. noise to the better ear) may be attributed to loss of attention and to the subsequent fatigue and "withdrawal" from the task at hand.



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MET overexpression and gene amplification: prevalence, clinico-pathological characteristics and prognostic significance in a large cohort of patients with surgically resected NSCLC

Abstract

The prevalence of overexpression and amplification of the proto-oncogene mesenchymal epithelial transition (MET) in non-small cell lung cancer (NSCLC) varies greatly in the literature. Since MET is a potential treatment target, knowledge of its prevalence and prognostic importance is crucial. We investigated MET expression and gene status in 735 NSCLC cases using tissue microarrays. Prognostic significance as well as correlations with various clinico-pathological parameters were evaluated. The prevalence of MET overexpression was 17% and MET amplification was present in 2.4% of cases. MET overexpression was found more frequently in adenocarcinomas (and TTF1-positive tumors) and female patients and was also associated with expression of members of the epidermal growth factor receptor (EGFR) signaling cascade. MET amplified tumors tended to express MET more frequently and more intensively. MET expression or gene status did not prove to be relevant prognostic factors. MET may not be an unequivocal prognostic parameter; however, its expression is associated with certain clinico-pathological characteristics and with EGFR and downstream EGFR effectors. This could be an important point for future studies addressing targeted MET therapy and should be considered as a possible means of optimizing the benefit and minimizing undesirable effects.

http://ift.tt/2qEIC8s

Presence of new mutations in the TP53 gene in patients with low-risk myelodysplastic syndrome: two case reports

Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are a...

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Hashimoto’s Encephalopathy Presenting with Unusual Behavioural Disturbances in an Adolescent Girl

Hashimoto's encephalopathy (HE) is a rare autoimmune disorder with neurological and neuropsychiatric manifestations and elevated titres of anti-thyroid antibodies. Here we are reporting a case of HE in a 19-year-old girl who presented with seizure-like episodes, confusion, and behavioural disturbances with catatonic symptoms such as posturing, echopraxia, echolalia, and ambivalence. Patient did not respond to antipsychotics and anticonvulsants. On further investigation, patient was found to have high serum anti-TPO antibodies of about 1261 U/mL with euthyroid status, which supported a suspicion of HE. Our consultant neurologist confirmed the diagnosis and she was started on injection of methylprednisolone 750 mg OD. Since patient started showing clinical improvement, her antipsychotic medications were tapered off. On follow-up, patient has recovered and is functioning well. Since HE is a diagnosis of exclusion, very high anti-TPO antibodies and good response to steroids supported the diagnosis of HE in this patient after excluding other etiological possibilities. This case has been reported because the clinical presentation was predominantly neurobehavioural manifestations which is uncommon with HE.

http://ift.tt/2rFkqkY

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.

Bartolome, F; Esteras, N; Martin-Requero, A; Boutoleau-Bretonniere, C; Vercelletto, M; Gabelle, A; Le Ber, I; Bartolome, F; Esteras, N; Martin-Requero, A; Boutoleau-Bretonniere, C; Vercelletto, M; Gabelle, A; Le Ber, I; Honda, T; Dinkova-Kostova, AT; Hardy, J; Carro, E; Abramov, AY; - view fewer (2017) Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates. Sci Rep , 7 (1) 1666-. 10.1038/s41598-017-01678-4 .

http://ift.tt/2qL2qWh

A randomized clinical trial comparing fixed vs pro-re-nata dosing of Ozurdex in refractory diabetic macular oedema (OZDRY study).

Ramu, J; Yang, Y; Menon, G; Bailey, C; Narendran, N; Bunce, C; Quartilho, A; Ramu, J; Yang, Y; Menon, G; Bailey, C; Narendran, N; Bunce, C; Quartilho, A; Prevost, AT; Hykin, P; Sivaprasad, S; OZDRY Study Group, ; - view fewer (2015) A randomized clinical trial comparing fixed vs pro-re-nata dosing of Ozurdex in refractory diabetic macular oedema (OZDRY study). Eye (Lond) , 29 (12) pp. 1603-1612. 10.1038/eye.2015.214 .

http://ift.tt/2pYOrPz

Slow-Release Dexamethasone in Proliferative Vitreoretinopathy: A Prospective, Randomized Controlled Clinical Trial.

Banerjee, PJ; Quartilho, A; Bunce, C; Xing, W; Zvobgo, TM; Harris, N; Charteris, DG; (2017) Slow-Release Dexamethasone in Proliferative Vitreoretinopathy: A Prospective, Randomized Controlled Clinical Trial. Ophthalmology 10.1016/j.ophtha.2017.01.021 .

http://ift.tt/2qLjX0r

Treatment trends for retinopathy of prematurity in the UK: active surveillance study of infants at risk

Adams, GGW; Bunce, C; Xing, W; Butler, L; Long, V; Reddy, A; Dahlmann-Noor, AH; (2017) Treatment trends for retinopathy of prematurity in the UK: active surveillance study of infants at risk. BMJ OPEN , 7 (ARTN e01) 10.1136/bmjopen-2016-013366 .

http://ift.tt/2pYNvuz

Ranibizumab pretreatment in diabetic vitrectomy: a pilot randomised controlled trial (the RaDiVit study).

Comyn, O; Wickham, L; Charteris, DG; Sullivan, PM; Ezra, E; Gregor, Z; Aylward, GW; Comyn, O; Wickham, L; Charteris, DG; Sullivan, PM; Ezra, E; Gregor, Z; Aylward, GW; da Cruz, L; Fabinyi, D; Peto, T; Restori, M; Xing, W; Bunce, C; Hykin, PG; Bainbridge, JW; - view fewer (2017) Ranibizumab pretreatment in diabetic vitrectomy: a pilot randomised controlled trial (the RaDiVit study). Eye (Lond) 10.1038/eye.2017.75 .

http://ift.tt/2qKZHfl

DEMONS ALGORITHMS FOR FLUID AND CURVATURE REGISTRATION

Cahill, ND; Noble, JA; Hawkes, DJ; (2009) DEMONS ALGORITHMS FOR FLUID AND CURVATURE REGISTRATION. In: (Proceedings) IEEE International Symposium on Biomedical Imaging - From Nano to Macro. (pp. 730-+). IEEE

http://ift.tt/2pYVdVe

A ROBUST MOSAICING METHOD FOR ROBOTIC ASSISTED MINIMALLY INVASIVE SURGERY

Hu, M; Hawkes, DJ; Penney, GP; Rueckert, D; Edwards, PJ; Bello, F; Figl, M; Hu, M; Hawkes, DJ; Penney, GP; Rueckert, D; Edwards, PJ; Bello, F; Figl, M; Casula, R; - view fewer (2010) A ROBUST MOSAICING METHOD FOR ROBOTIC ASSISTED MINIMALLY INVASIVE SURGERY. In: Filipe, J and Cetto, JA and Ferrier, JL, (eds.) (Proceedings) 7th International Conference on Informatics in Control, Automation and Robotics. (pp. pp. 206-211). INSTICC-INST SYST TECHNOLOGIES INFORMATION CONTROL & COMMUNICATION

http://ift.tt/2qL2gye

ACCOUNTING FOR CHANGING OVERLAP IN VARIATIONAL IMAGE REGISTRATION

Cahill, ND; Noble, JA; Hawkes, DJ; (2010) ACCOUNTING FOR CHANGING OVERLAP IN VARIATIONAL IMAGE REGISTRATION. In: (Proceedings) 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro. (pp. pp. 384-387). IEEE

http://ift.tt/2pZdn9u

Model-based blood flow quantification from DSA: quantitative evaluation on patient data and comparison with TCCD

Waechter-Stehle, I; Groth, A; Bruijns, T; Brina, O; Ruefenacht, DA; Kulcsar, Z; Mendes-Pereira, V; Waechter-Stehle, I; Groth, A; Bruijns, T; Brina, O; Ruefenacht, DA; Kulcsar, Z; Mendes-Pereira, V; Perren, F; Hawkes, DJ; Weese, J; - view fewer (2012) Model-based blood flow quantification from DSA: quantitative evaluation on patient data and comparison with TCCD. In: Haynor, DR and Ourselin, S, (eds.) (Proceedings) Conference on Medical Imaging - Image Processing. SPIE-INT SOC OPTICAL ENGINEERING

http://ift.tt/2qL2plb

Human Factors Effecting Forensic Decision Making: Workplace Stress and Well-being

Jeanguenat, AM; Dror, IE; (2017) Human Factors Effecting Forensic Decision Making: Workplace Stress and Well-being. Journal of Forensic Sciences 10.1111/1556-4029.13533 . (In press).

http://ift.tt/2pYLxKE

ACCEPTANCE TESTING AND QUALITY-CONTROL IN DIGITAL FLUOROGRAPHY

HAWKES, DJ; FITZGERALD, M; BELLI, A; TILLER, G; STEWART, A; (1987) ACCEPTANCE TESTING AND QUALITY-CONTROL IN DIGITAL FLUOROGRAPHY. In: (pp. p. 793). BRITISH INST RADIOLOGY

http://ift.tt/2qL13a2

Combined and three-dimensional rendered multimodal data for planning cranial base surgery: a prospective evaluation.

Gandhe, AJ; Hill, DL; Studholme, C; Hawkes, DJ; Ruff, CF; Cox, TC; Gleeson, MJ; Gandhe, AJ; Hill, DL; Studholme, C; Hawkes, DJ; Ruff, CF; Cox, TC; Gleeson, MJ; Strong, AJ; - view fewer (1994) Combined and three-dimensional rendered multimodal data for planning cranial base surgery: a prospective evaluation. Neurosurgery , 35 (3) pp. 463-470.

http://ift.tt/2pZ46OX

Craniotomy guidance using a stereo-video-based tracking system

Thomas, DGT; Doshi, P; Colchester, A; Hawkes, DJ; Hill, DLC; Zhao, J; Maitland, N; Thomas, DGT; Doshi, P; Colchester, A; Hawkes, DJ; Hill, DLC; Zhao, J; Maitland, N; Strong, AJ; Evans, RI; - view fewer (1996) Craniotomy guidance using a stereo-video-based tracking system. In: (Proceedings) Scientific Meeting of the American-Society-for-Stereotactic-Functional-Neurosurgery. (pp. pp. 81-83). KARGER

http://ift.tt/2qL2oxD

Image guidance for robotic minimally invasive coronary artery bypass

Figl, M; Rueckert, D; Hawkes, D; Casula, R; Hu, M; Pedro, O; Zhang, DP; Figl, M; Rueckert, D; Hawkes, D; Casula, R; Hu, M; Pedro, O; Zhang, DP; Penney, G; Bello, F; Edwards, P; - view fewer (2008) Image guidance for robotic minimally invasive coronary artery bypass. In: Dohi, T and Sakuma, I and Liao, H, (eds.) (Proceedings) 4th International Workshop on Medical Imaging and Augmented Reality. (pp. 202-+). SPRINGER-VERLAG BERLIN

http://ift.tt/2pZdwtL

Using flow information to support 3D vessel reconstruction from rotational angiography.

Waechter, I; Bredno, J; Weese, J; Barratt, DC; Hawkes, DJ; (2008) Using flow information to support 3D vessel reconstruction from rotational angiography. Med Phys , 35 (7Part1) pp. 3302-3316. 10.1118/1.2938729 .

http://ift.tt/2qKWFI0

Revisiting Overlap Invariance in Medical Image Alignment

Cahill, ND; Schnabel, JA; Noble, JA; Hawkes, DJ; (2008) Revisiting Overlap Invariance in Medical Image Alignment. In: (Proceedings) IEEE Conference on Computer Vision and Pattern Recognition. (pp. 288-+). IEEE

http://ift.tt/2pYZXKy

Clinicopathologic and molecular spectrum of RNASEH1-related mitochondrial disease.

Bugiardini, E; Poole, OV; Manole, A; Pittman, AM; Horga, A; Hargreaves, I; Woodward, CE; Bugiardini, E; Poole, OV; Manole, A; Pittman, AM; Horga, A; Hargreaves, I; Woodward, CE; Sweeney, MG; Holton, JL; Taanman, J-W; Plant, GT; Poulton, J; Zeviani, M; Ghezzi, D; Taylor, J; Smith, C; Fratter, C; Kanikannan, MA; Paramasivam, A; Thangaraj, K; Spinazzola, A; Holt, IJ; Houlden, H; Hanna, MG; Pitceathly, RDS; - view fewer (2017) Clinicopathologic and molecular spectrum of RNASEH1-related mitochondrial disease. Neurol Genet , 3 (3) , Article e149. 10.1212/NXG.0000000000000149 .

http://ift.tt/2qKWH2A

Predictors of estimated glomerular filtration rate progression, stabilization or improvement after chronic renal impairment in HIV-positive individuals.

Ryom, L; Mocroft, A; Kirk, O; Reiss, P; Ross, M; Smith, C; Moranne, O; Ryom, L; Mocroft, A; Kirk, O; Reiss, P; Ross, M; Smith, C; Moranne, O; Morlat, P; Fux, CA; Sabin, C; Phillips, A; Law, M; Lundgren, JD; D:A:D study group, ; - view fewer (2017) Predictors of estimated glomerular filtration rate progression, stabilization or improvement after chronic renal impairment in HIV-positive individuals. AIDS , 31 (9) pp. 1261-1270. 10.1097/QAD.0000000000001464 .

http://ift.tt/2pYNsin

Breast MRI segmentation for density estimation: Do different methods give the same results and how much do differences matter?

Doran, SJ; Hipwell, JH; Denholm, R; Eiben, B; Busana, M; Hawkes, DJ; Leach, MO; Doran, SJ; Hipwell, JH; Denholm, R; Eiben, B; Busana, M; Hawkes, DJ; Leach, MO; Dos Santos Silva, I; - view fewer (2017) Breast MRI segmentation for density estimation: Do different methods give the same results and how much do differences matter? Med Phys 10.1002/mp.12320 .

http://ift.tt/2qLjRWD

A Constellation of Rare Findings in a Case of Goldenhar Syndrome

An 18-month-old child presented with right macrostomia, bilateral preauricular skin tags, bilateral CTEV, squint in bilateral eyes, thoracic vertebral anomalies, right sided aortic arch, and associated left pulmonary agenesis. The patient did not have any associated respiratory symptoms. Ipsilateral pulmonary agenesis is considered as a rare association with Goldenhar syndrome and a case of contralateral pulmonary aplasia has been described as an even rarer association.

http://ift.tt/2r5ESyo

Outcomes of external septorhinoplasty in a Turkish male population

Publication date: Available online 20 May 2017
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Mustafa Çelik, Gamze Didem Kilci, Engin Başer, Ayşegül Verim, Ömer Faruk Çalim, Bayram Veyseller, Orhan Özturan, Ahmet Altintaş
IntroductionThe first and one of the most important steps in facial plastic surgery is accurate preoperative facial analysis and recording of data that may help the surgeon to check the outcomes of his/her techniques, promoting a surgeon's professional development.ObjectiveTo evaluate the esthetic outcomes of external septorhinoplasty (SRP) relevant to ethnic facial harmony and to investigate the relationship of the columellar incision scar with the type of skin and columellar incision type in a Turkish population.MethodsIn total, 28 consecutive adult male patients with a mean age of 32.14±10.66 years (range: 18–61 years) were included the study. Primary outcomes were preoperative and postoperative photogrammetric facial analyses of the patients including measurement of nasofrontal angle, nasolabial angle and nasal projection ratios (Gode) assessed according to the data derived from the Rhinobase program. Results were compared to facial proportions of the Turkish population. Columellar incision scar scores related to the Fitzpatrick skin type classification of the patients and columellar incision types used for the external approach were secondary outcomes of the study.ResultsMean preoperative and postoperative nasofrontal angles were 148.04°±8.18° and 144.50°±7.15°, respectively, while mean preoperative and postoperative nasolabial angles were 87.59°±14.01° and 98.50°±9.71°, respectively. Mean preoperative and postoperative nasal tip projection ratios were 0.56±0.05 and 0.60±0.06, respectively. The differences between pre- and postoperative measurements were all significantly different and were in accordance with Turkish nasal harmony. Columellar inverted "V" incisions were performed in 15 (53.6%) patients while "V" incisions were used in 13 (46.4%) patients. Fitzpatrick skin Type 4 was seen in 46.42% of the patients, Fitzpatrick Type 3 in 46.42% and Fitzpatrick Type 2 in 7.14% of the patients. No significant difference was seen between columellar scar scores according to skin type and columellar incision type used for external septorhinoplasty.ConclusionsThis study demonstrated that outcomes for nasofrontal angle, nasolabial angle and nasal tip projection ratios analyzed using the Rhinobase program in patients who underwent external septorhinoplasty were similar to reference values for the Turkish population.



http://ift.tt/2rEWLBa

Policy instruments for low-carbon development based on work from the EUFP7 project, CECILIA2050: Combining policy instruments to achieve Europe's 2050 climate targets

Ekins, P; Drummond, P; Goerlach, B; (2017) Policy instruments for low-carbon development based on work from the EUFP7 project, CECILIA2050: Combining policy instruments to achieve Europe's 2050 climate targets. CLIMATE POLICY , 17 S1-S7. 10.1080/14693062.2016.1272044 .

http://ift.tt/2qHrz6n

Health care resource use by patients before and after a diagnosis of chronic fatigue syndrome (CFS/ME): a clinical practice research datalink study.

Collin, SM; Bakken, IJ; Nazareth, I; Crawley, E; White, PD; (2017) Health care resource use by patients before and after a diagnosis of chronic fatigue syndrome (CFS/ME): a clinical practice research datalink study. BMC Fam Pract , 18 (1) 60-. 10.1186/s12875-017-0635-z .

http://ift.tt/2rFB9nh

Association Between Long-term Quinine Exposure and All-Cause Mortality.

Fardet, L; Nazareth, I; Petersen, I; (2017) Association Between Long-term Quinine Exposure and All-Cause Mortality. JAMA , 317 (18) pp. 1907-1909. 10.1001/jama.2017.2332 .

http://ift.tt/2qHm1IO

What is the overlap between HIV and shigellosis epidemics in England: further evidence of MSM transmission?

Mohan, K; Hibbert, M; Rooney, G; Canvin, M; Childs, T; Jenkins, C; Simms, I; Mohan, K; Hibbert, M; Rooney, G; Canvin, M; Childs, T; Jenkins, C; Simms, I; Kirwan, P; Delpech, V; Yin, Z; Hughes, G; Field, N; - view fewer (2017) What is the overlap between HIV and shigellosis epidemics in England: further evidence of MSM transmission? Sex Transm Infect 10.1136/sextrans-2016-052962 .

http://ift.tt/2rFOc8d

The association between psychological stress and miscarriage: A systematic review and meta-analysis.

Qu, F; Wu, Y; Zhu, Y-H; Barry, J; Ding, T; Baio, G; Muscat, R; Qu, F; Wu, Y; Zhu, Y-H; Barry, J; Ding, T; Baio, G; Muscat, R; Todd, BK; Wang, F-F; Hardiman, PJ; - view fewer (2017) The association between psychological stress and miscarriage: A systematic review and meta-analysis. Sci Rep , 7 (1) 1731-. 10.1038/s41598-017-01792-3 .

http://ift.tt/2qHzuAo

How to Image the Adult Patient With Fontan Circulation.

Hauser, JA; Taylor, AM; Pandya, B; (2017) How to Image the Adult Patient With Fontan Circulation. Circ Cardiovasc Imaging , 10 (5) 10.1161/CIRCIMAGING.116.004273 .

http://ift.tt/2rG2bea

EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones

(2016) EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones. Journal of Hepatology , 65 (1) pp. 146-181. 10.1016/j.jhep.2016.03.005 .

http://ift.tt/2qHCUDj

An Uncommon Site of Streptococcus pneumoniae Colonization Leading to Recurrent Pneumococcal Disease.

Sendi, P; Moser Schaub, EM; Nirgianakis, K; Hathaway, LJ; Bittel, P; Goldblatt, D; Streit, S; (2017) An Uncommon Site of Streptococcus pneumoniae Colonization Leading to Recurrent Pneumococcal Disease. Open Forum Infect Dis , 4 (1) ofw257-. 10.1093/ofid/ofw257 .

http://ift.tt/2rFLks6

Occupational class and working beyond the retirement age: a cohort study.

Virtanen, M; Oksanen, T; Pentti, J; Ervasti, J; Head, J; Stenholm, S; Vahtera, J; Virtanen, M; Oksanen, T; Pentti, J; Ervasti, J; Head, J; Stenholm, S; Vahtera, J; Kivimäki, M; - view fewer (2017) Occupational class and working beyond the retirement age: a cohort study. Scand J Work Environ Health 10.5271/sjweh.3645 .

http://ift.tt/2qHJ7it

Biomechanics of the transport barrier in the nuclear pore complex.

Stanley, GJ; Fassati, A; Hoogenboom, BW; (2017) Biomechanics of the transport barrier in the nuclear pore complex. Semin Cell Dev Biol 10.1016/j.semcdb.2017.05.007 .

http://ift.tt/2rFzpKI

Optimizing psychosocial adjustment after deep brain stimulation of the subthalamic nucleus in Parkinson's disease.

Shahmoon, S; Jahanshahi, M; (2017) Optimizing psychosocial adjustment after deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Mov Disord 10.1002/mds.27032 .

http://ift.tt/2qHAmoX

Evaluation of a social franchising and telemedicine programme and the care provided for childhood diarrhoea and pneumonia, Bihar, India.

Mohanan, M; Giardili, S; Das, V; Rabin, TL; Raj, SS; Schwartz, JI; Seth, A; Mohanan, M; Giardili, S; Das, V; Rabin, TL; Raj, SS; Schwartz, JI; Seth, A; Goldhaber-Fiebert, JD; Miller, G; Vera-Hernández, M; - view fewer (2017) Evaluation of a social franchising and telemedicine programme and the care provided for childhood diarrhoea and pneumonia, Bihar, India. Bull World Health Organ , 95 (5) 343-352E. 10.2471/BLT.16.179556 .

http://ift.tt/2rFDG0W

CHASE OBSERVATIONS OF THE SOLAR CORONA

BREEVELD, ER; CULHANE, JL; NORMAN, K; PARKINSON, JH; GABRIEL, AH; LANG, J; PATCHETT, BE; BREEVELD, ER; CULHANE, JL; NORMAN, K; PARKINSON, JH; GABRIEL, AH; LANG, J; PATCHETT, BE; PAYNE, J; - view fewer (1988) CHASE OBSERVATIONS OF THE SOLAR CORONA. ASTROPHYSICAL LETTERS & COMMUNICATIONS , 27 (3) pp. 155-161.

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FLARE PATH

CULHANE, JL; CRUISE, AM; LANG, J; (1991) FLARE PATH. NATURE , 353 (6341) p. 204. 10.1038/353204c0 .

http://ift.tt/2rFPMXK

HELIUM-LIKE SULFUR EMISSION-LINES IN SOLAR ACTIVE REGIONS AND THEIR SUB-C CLASS VARIABILITY

WATANABE, T; HIEI, E; LANG, J; CULHANE, JL; BENTLEY, RD; DOSCHEK, GA; BROMAGE, BJI; WATANABE, T; HIEI, E; LANG, J; CULHANE, JL; BENTLEY, RD; DOSCHEK, GA; BROMAGE, BJI; BROWN, CM; FELDMAN, U; FLUDRA, A; KATO, T; PAYNE, J; - view fewer (1992) HELIUM-LIKE SULFUR EMISSION-LINES IN SOLAR ACTIVE REGIONS AND THEIR SUB-C CLASS VARIABILITY. PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF JAPAN , 44 (5) L141-L145.

http://ift.tt/2qHnL4U

THE PERFORMANCE OF THE YOHKOH BRAGG CRYSTAL SPECTROMETER

LANG, J; BENTLEY, RD; BROWN, CM; CULHANE, JL; DOSCHEK, GA; WATANABE, T; HIEI, E; LANG, J; BENTLEY, RD; BROWN, CM; CULHANE, JL; DOSCHEK, GA; WATANABE, T; HIEI, E; DESLATTES, RD; FLUDRA, A; GUTTRIDGE, PR; MAGRAW, JE; PAYNE, J; PIKE, CD; TROW, MW; - view fewer (1992) THE PERFORMANCE OF THE YOHKOH BRAGG CRYSTAL SPECTROMETER. PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF JAPAN , 44 (5) L55-L61.

http://ift.tt/2rFMQKX

THE 1991 NOVEMBER 9 FLARE AT 03.2-UT - OBSERVATIONS FROM YOHKOH

DOSCHEK, GA; MARISKA, JT; STRONG, KT; BENTLEY, RD; BROWN, CM; CULHANE, JL; LANG, J; DOSCHEK, GA; MARISKA, JT; STRONG, KT; BENTLEY, RD; BROWN, CM; CULHANE, JL; LANG, J; STERLING, AC; WATANABE, T; - view fewer (1994) THE 1991 NOVEMBER 9 FLARE AT 03.2-UT - OBSERVATIONS FROM YOHKOH. ASTROPHYSICAL JOURNAL , 431 (2) pp. 888-900. 10.1086/174540 .

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Pain Assessment in INTensive care (PAINT): an observational study of physician-documented pain assessment in 45 intensive care units in the United Kingdom

Kemp, HI; Bantel, C; Gordon, F; Brett, SJ; Laycock, HC; Bampoe, S; Bantel, C; Kemp, HI; Bantel, C; Gordon, F; Brett, SJ; Laycock, HC; Bampoe, S; Bantel, C; Gooneratne, M; Highton, D; Hopkins, P; Johnston, C; Odor, P; Kemp, H; Laycock, H; Martin, D; O'Carroll, J; Phillips, S; Visram, A; Siddique, O; Burdett, E; May, R; Renwick, S; Gray, M; Spiro, M; Luoma, V; Chamarette, H; Young, T; Wagstaff, D; Lewith, H; Gowrie, S; Bramall, J; Collison, L; Mansell, J; Hamilton, K; Leigh, A; Dawson, J; Morkane, C; Balla, P; Shukla, B; Rublotta, F; Cousins, J; Magee, D; Cashell, C; Kooner, G; Arnold, G; Garnelo Ray, V; Clancy, O; Whitehead, N; Kooner, G; Handy, J; Vizcaychipi, M; Edwards, Z; Davis-Hall, M; Addy, M; Jhanji, S; Wigmore, T; Christie, L; Sidon, L; Grover, M; Panagoda, P; Howells, L; Cartwright, C; Doyle, R; Griffith, M; Casely, E; Holdgate, A; Rich, S; Henriksson, M; Jaggar, S; Tatham, K; Kadry, M; Finlay, C; Pandit, A; Mehdipour, S; Ong, C; Bidd, H; Ramessur, S; Anwar, S; Blunt, N; Williams, H; Tosini, C; Parini, A; Kumar, R; Ferrier, V; Gupta, A; Canavan, A; Dickinson, M; Carey, B; Somasundaram, K; De Silva, S; Moghulm, A; Dua, K; McHugh, B; Chapman, R; Peck, M; Sangam, A; Al-Sahaf, H; Gowripalann, T; Kunnumpurath, S; - view fewer (2017) Pain Assessment in INTensive care (PAINT): an observational study of physician-documented pain assessment in 45 intensive care units in the United Kingdom. Anaesthesia , 72 (6) pp. 737-748. 10.1111/anae.13786 . (In press).

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Unreliability of putative fMRI biomarkers during emotional face processing.

Nord, CL; Gray, A; Charpentier, CJ; Robinson, OJ; Roiser, JP; (2017) Unreliability of putative fMRI biomarkers during emotional face processing. Neuroimage 10.1016/j.neuroimage.2017.05.024 .

http://ift.tt/2qHxk3Q

Chronic Stroke Survivors Improve Reaching Accuracy by Reducing Movement Variability at the Trained Movement Speed.

Hammerbeck, U; Yousif, N; Hoad, D; Greenwood, R; Diedrichsen, J; Rothwell, JC; (2017) Chronic Stroke Survivors Improve Reaching Accuracy by Reducing Movement Variability at the Trained Movement Speed. Neurorehabil Neural Repair , 31 (6) pp. 499-508. 10.1177/1545968317693112 .

http://ift.tt/2rFKfAD

Effect of vitamin D replacement on immunological biomarkers in patients with multiple sclerosis

Publication date: Available online 20 May 2017
Source:Clinical Immunology
Author(s): May F. Mrad, Nabil K. El Ayoubi, Maria O. Esmerian, Jalal M. Kazan, Samia J. Khoury
We aimed to investigate the immunologic effects of vitamin D replacement in RRMS patients. In a controlled single center study, patients deficient in 25-hydroxyvitamin D (serum level<25ng/ml) received 10,000IU/week cholecalciferol for 3months. Sufficient vitamin D patients (serum level>35ng/ml) were followed for the same period. Assessments were performed at baseline and at 3months. 25-hydroxyvitamin D levels increased significantly from baseline to month-3 in the deficient group after treatment and remained stable in the sufficient group. We observed a decreased interferon-γ (IFNγ) secretion by CD4⁺ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNγ production. There was no change in the frequency of T helper or regulatory T cell subsets in either group. Increasing serum levels of 25-hydroxyvitamin D are associated with decreased production of IFNγ by CD4⁺ T cells.



http://ift.tt/2r59yQu

Income is an independent risk factor for worse asthma outcomes

Publication date: Available online 20 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Juan Carlos Cardet, Margee Louisias, Tonya S. King, Mario Castro, Christopher D. Codispoti, Ryan Dunn, Linda Engle, B. Louise Giles, Fernando Holguin, John J. Lima, Dayna Long, Njira Lugogo, Sharmilee Nyenhuis, Victor E. Ortega, Sima Ramratnam, Michael E. Wechsler, Elliot Israel, Wanda Phipatanakul
BackgroundSocioeconomic status (SES) is associated with asthma morbidity in observational studies but the factors underlying this association are uncertain.ObjectiveWe investigated whether three SES correlates—low income, low education, and high perceived stress— were independent risk factors for treatment failure and asthma exacerbations in the context of a randomized controlled trial (RCT).MethodsThe effect of low SES [household income (defined as <$50,000/year), household educational level (defined as less than a bachelor's degree) and high perceived stress (defined as a score of >20 on a perceived stress scale)] on asthma morbidity was analyzed in 381 participants utilizing Poisson regression models. The primary outcome was treatment failure (defined in the trial protocol as a significant clinical or airflow deterioration) and the secondary outcome was asthma exacerbations requiring systemic corticosteroids.Results54% of participants had a low income, 40% had a low educational level, and 17% had high perceived stress levels. Even after adjusting for race and other important confounders, participants with lower income had higher rates of both treatment failures [RR=1.6, 95%CI 1.1-2.3, p=0.03] and exacerbations [RR=1.9, 95%CI 1.1-3.3, p=0.02]. Adherence with inhaled corticosteroids was similarly high for both income categories. Education and perceived stress were not significantly associated with either outcome.ConclusionsIn the context of a RCT, participants with lower income were more likely to experience adverse asthma outcomes independent of education, perceived stress, race, and medication adherence.

Teaser

Asthma outcomes are worse in low income groups, regardless of race, BMI, perceived stress, inhaled corticosteroid dose or adherence, baseline asthma control, and second-hand smoke exposure. This suggests that clinicians and researchers should consider income when managing patients and designing interventions.


http://ift.tt/2q8IRFn

Frequency of untreated hypogammaglobulinemia in bronchiectasis

Publication date: Available online 20 May 2017
Source:Annals of Allergy, Asthma & Immunology
Author(s): Melanie A. Ruffner, Timothy R. Aksamit, Byron Thomashow, Radmila Choate, Angela DiMango, Gerard M. Turino, Anne E. O'Donnell, Margaret M. Johnson, Kenneth N. Olivier, Kevin Fennelly, Charles L. Daley, Kevin L. Winthrop, Mark L. Metersky, Matthias A. Salathe, Michael R. Knowles, M. Leigh Anne Daniels, Peadar G. Noone, Gregory Tino, David E. Griffith, Kathleen E. Sullivan




http://ift.tt/2qDpesA

A survey of inpatient practitioner knowledge of penicillin allergy at 2 community teaching hospitals

Publication date: Available online 20 May 2017
Source:Annals of Allergy, Asthma & Immunology
Author(s): Mary L. Staicu, Dipekka Soni, Kelly M. Conn, Allison Ramsey
BackgroundThe negative effect of the penicillin allergy label on antibiotic use and patient outcomes has brought to light the need for thorough penicillin allergy assessments and heightened practitioner education.ObjectiveTo evaluate practitioner knowledge of penicillin allergy and the clinical approach to the patients with penicillin allergy.MethodsAn electronic survey was distributed to attending physicians, residents, pharmacists, nurse practitioners, and physician assistants practicing adult inpatient medicine at 2 community-based teaching hospitals from February to April 2016.ResultsA total of 276 (39%) of 716 practitioners completed surveys were analyzed. Most respondents were attending physicians (45%) with more than 10 years of experience (53%). Approximately half of the respondents indicated that they were unfamiliar with the rate of cross-reactivity between penicillin and cephalosporin (46%), carbapenem (42%), and monobactam (48%) antibiotics. When evaluating the role of penicillin skin testing and temporary induction of drug tolerance in the case vignettes, only 41% and 19% of respondents appropriately considered these options as the leading antibiotic management plan, respectively. Despite acknowledging the need for allergy/immunology consultation in clinical scenarios, 86% of respondents indicated that they never consult an allergist or immunologist or do so only once per year. Overall, pharmacists had a better understanding of the natural history of penicillin allergy and antibiotic cross-reactivity (P < .05).ConclusionThere is an overall limited understanding of the management of patients with a history of penicillin allergy in the hospital setting, where collaborative efforts between allergy and nonallergy health care practitioners are sparse. The expansion of a multidisciplinary approach may optimize antimicrobial prescribing in this subset of patients.



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Social Cues Support Learning about Objects from Statistics in Infancy

Wu, R; Gopnik, A; Richardson, DC; Kirkham, NZ; (2010) Social Cues Support Learning about Objects from Statistics in Infancy. In: Ohlsson, S and Catrambone, R, (eds.) (Proceedings) 32nd Annual Meeting of the Cognitive-Science-Society. (pp. pp. 1228-1233). COGNITIVE SCIENCE SOCIETY, INC

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POROUS MATERIALS Look but don't touch

Slater, B; Ling, S; (2017) POROUS MATERIALS Look but don't touch. NATURE MATERIALS , 16 (5) pp. 501-502.

http://ift.tt/2qHkfHH

Single dose Rasburicase is a clinically effective pharmacoeconomic approach for preventing tumour lysis syndrome in children with high tumour burden.

Syrimi, E; Gunasekera, S; Norton, A; Velangi, M; Motwani, J; Hiwarkar, P; (2017) Single dose Rasburicase is a clinically effective pharmacoeconomic approach for preventing tumour lysis syndrome in children with high tumour burden. Br J Haematol 10.1111/bjh.14689 .

http://ift.tt/2rFkW1q

The Effects of Transcranial Magnetic Stimulation over Premotor Cortex on the Perception of Biological Motion

van Kemenade, B; Muggleton, N; Walsh, V; Saygin, AP; (2010) The Effects of Transcranial Magnetic Stimulation over Premotor Cortex on the Perception of Biological Motion. In: Ohlsson, S and Catrambone, R, (eds.) (Proceedings) 32nd Annual Meeting of the Cognitive-Science-Society. (pp. p. 2439). COGNITIVE SCIENCE SOCIETY, INC

http://ift.tt/2qH0Dni

Combined TMS/fMRI reveals dissociable cortical pathways for dynamic and static faces

Pitcher, DD; Duchaine, B; Walsh, V; (2014) Combined TMS/fMRI reveals dissociable cortical pathways for dynamic and static faces. In: (pp. p. 122). SAGE PUBLICATIONS LTD

http://ift.tt/2rFl413

STATUS OF THE PILOT BALLOON-BORNE EXPERIMENT

Engel, C; Ade, P; Bernard, J-P; deBernardis, P; Bouzit, M; Giard, M; Griffin, M; Engel, C; Ade, P; Bernard, J-P; deBernardis, P; Bouzit, M; Giard, M; Griffin, M; Hargrave, P; Laurens, A; Leriche, B; Leroy, C; Longval, Y; Madden, S; Maffei, B; Marty, C; Masi, S; Meny, C; Miville-Deschenes, M-A; Narbonne, J; Nati, L; Pajot, F; Pisano, G; Pointecouteau, E; Ponthieu, N; Ristorcelli, I; Rodriguez, L; Roudil, G; Salatino, M; Savini, G; Torre, G; Tucker, C; - view fewer (2009) STATUS OF THE PILOT BALLOON-BORNE EXPERIMENT. In: Lacoste, H, (ed.) (Proceedings) 19th ESA Symposium on European Rocket and Balloon Programmes and Related Research. (pp. pp. 579-583). EUROPEAN SPACE AGENCY

http://ift.tt/2qH1Sm7

Advancing toward far-infrared interferometry in space through coordinated international efforts

Leisawitz, D; Baryshev, A; Griffin, MJ; Helmich, FP; Ivison, RJ; Rinehart, SA; Savini, G; Leisawitz, D; Baryshev, A; Griffin, MJ; Helmich, FP; Ivison, RJ; Rinehart, SA; Savini, G; Shibai, H; - view fewer (2013) Advancing toward far-infrared interferometry in space through coordinated international efforts. In: MacEwen, HA and Breckinridge, JB, (eds.) (Proceedings) Conference on UV/Optical/IR Space Telescopes and Instruments - Innovative Technologies and Concepts VI. SPIE-INT SOC OPTICAL ENGINEERING

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RXRB is a MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis.

Oka, A; Asano, Y; Hasegawa, M; Fujimoto, M; Ishikawa, O; Kuwana, M; Kawaguchi, Y; Oka, A; Asano, Y; Hasegawa, M; Fujimoto, M; Ishikawa, O; Kuwana, M; Kawaguchi, Y; Yamamoto, T; Takahashi, H; Goto, D; Endo, H; Jinnin, M; Mano, S; Hosomichi, K; Mabuchi, T; Ueda, MT; Nakagawa, S; Beck, S; Bahram, S; Takehara, K; Sato, S; Ihn, H; - view fewer (2017) RXRB is a MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis. J Invest Dermatol 10.1016/j.jid.2017.04.028 .

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Cell-type deconvolution in epigenome-wide association studies: a review and recommendations.

Teschendorff, AE; Zheng, SC; (2017) Cell-type deconvolution in epigenome-wide association studies: a review and recommendations. Epigenomics , 9 (5) pp. 757-768. 10.2217/epi-2016-0153 .

http://ift.tt/2rFjCeV

Metal-Organic Nanosheets Formed via Defect-Mediated Transformation of a Hafnium Metal-Organic Framework

Cliffe, MJ; Castillo-Martinez, E; Wu, Y; Lee, J; Forse, AC; Firth, FCN; Moghadam, PZ; Cliffe, MJ; Castillo-Martinez, E; Wu, Y; Lee, J; Forse, AC; Firth, FCN; Moghadam, PZ; Fairen-Jimenez, D; Gaultois, MW; Hill, JA; Magdysyuk, OV; Slater, B; Goodwin, AL; Grey, CP; - view fewer (2017) Metal-Organic Nanosheets Formed via Defect-Mediated Transformation of a Hafnium Metal-Organic Framework. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 139 (15) pp. 5397-5404. 10.1021/jacs.7b00106 .

http://ift.tt/2qHd1mZ

Dietary pattern, inflammation and cognitive decline: The Whitehall II prospective cohort study

Ozawa, M; Shipley, M; Kivimaki, M; Singh-Manoux, A; Brunner, EJ; (2017) Dietary pattern, inflammation and cognitive decline: The Whitehall II prospective cohort study. CLINICAL NUTRITION , 36 (2) pp. 506-512. 10.1016/j.clau.2016.01.013 .

http://ift.tt/2rF32Mk

The interplay between neuroendocrine activity and psychological stress-induced exacerbation of allergic asthma

Publication date: Available online 20 May 2017
Source:Allergology International
Author(s): Tomomitsu Miyasaka, Kaori Dobashi-Okuyama, Tomoko Takahashi, Motoaki Takayanagi, Isao Ohno
Psychological stress is recognized as a key factor in the exacerbation of allergic asthma, whereby brain responses to stress act as immunomodulators for asthma. In particular, stress-induced enhanced type 2 T-helper (Th2)-type lung inflammation is strongly associated with asthma pathogenesis. Psychological stress leads to eosinophilic airway inflammation through activation of the hypothalamic-pituitary-adrenal pathway and autonomic nervous system. This is followed by the secretion of stress hormones into the blood, including glucocorticoids, epinephrine, and norepinephrine, which enhance Th2 and type 17 T-helper (Th17)-type asthma profiles in humans and rodents. Recent evidence has shown that a defect of the μ-opioid receptor in the brain along with a defect of the peripheral glucocorticoid receptor signaling completely disrupted stress-induced airway inflammation in mice. This suggests that the stress response facilitates events in the central nervous and endocrine systems, thus exacerbating asthma. In this review, we outline the recent findings on the interplay between stress and neuroendocrine activities followed by stress-induced enhanced Th2 and Th17 immune responses and attenuated regulatory T (Treg) cell responses that are closely linked with asthma exacerbation. We will place a special focus on our own data that has emphasized the continuity from central sensing of psychological stress to enhanced eosinophilic airway inflammation. The mechanism that modulates psychological stress-induced exacerbation of allergic asthma through neuroendocrine activities is thought to involve a series of consecutive pathological events from the brain to the lung, which implies there to be a "neuropsychiatry phenotype" in asthma.



http://ift.tt/2qH1CDU

Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study.

Singh-Manoux, A; Dugravot, A; Fournier, A; Abell, J; Ebmeier, K; Kivimäki, M; Sabia, S; (2017) Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study. JAMA Psychiatry 10.1001/jamapsychiatry.2017.0660 .

http://ift.tt/2qH97e5

The heterogeneity of systemic inflammation in bronchiectasis.

Saleh, AD; Chalmers, JD; De Soyza, A; Fardon, TC; Koustas, SO; Scott, J; Simpson, AJ; Saleh, AD; Chalmers, JD; De Soyza, A; Fardon, TC; Koustas, SO; Scott, J; Simpson, AJ; Brown, JS; Hurst, JR; - view fewer (2017) The heterogeneity of systemic inflammation in bronchiectasis. Respir Med , 127 pp. 33-39. 10.1016/j.rmed.2017.04.009 .

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Discussion: Measurement and Instrumentation

Andreani, C; Ceriotti, M; Fernandez-Alonso, F; Gorini, G; Krzystyniak, M; Parmentier, A; Parker, S; Andreani, C; Ceriotti, M; Fernandez-Alonso, F; Gorini, G; Krzystyniak, M; Parmentier, A; Parker, S; Seel, A; Senesi, R; Walewski, L; - view fewer (2014) Discussion: Measurement and Instrumentation. In: (Proceedings) 6th Workshop in Electron Volt Neutron Spectroscopy - Frontiers and Horizons. IOP PUBLISHING LTD

http://ift.tt/2qH1CDV

Discussion: Nuclear Quantum Dynamics - Protons and Beyond

Andreani, C; Ceriotti, M; Chass, G; Drechsel-Grau, C; Fernandez-Alonso, F; Greaves, N; Gidopoous, N; Andreani, C; Ceriotti, M; Chass, G; Drechsel-Grau, C; Fernandez-Alonso, F; Greaves, N; Gidopoous, N; Krzystyniak, M; Parmentier, A; Refson, K; Reiter, GF; Romanelli, G; Seel, A; Walewski, L; Wiles, T; - view fewer (2014) Discussion: Nuclear Quantum Dynamics - Protons and Beyond. In: (Proceedings) 6th Workshop in Electron Volt Neutron Spectroscopy - Frontiers and Horizons. IOP PUBLISHING LTD

http://ift.tt/2rFm4Cq

Over the Horizon: Future Roles of Electron Volt Neutron Spectroscopy

Seel, AG; Krzystyniak, M; Senesi, R; Fernandez-Alonso, F; (2014) Over the Horizon: Future Roles of Electron Volt Neutron Spectroscopy. In: (Proceedings) 6th Workshop in Electron Volt Neutron Spectroscopy - Frontiers and Horizons. IOP PUBLISHING LTD

http://ift.tt/2qH7Cwl

A Prospective Risk Assessment of Informal Carers' Medication Administration Errors within the Domiciliary Setting.

Parand, A; Faiella, G; Franklin, BD; Johnston, M; Clemente, F; Stanton, NA; Sevdalis, N; (2017) A Prospective Risk Assessment of Informal Carers' Medication Administration Errors within the Domiciliary Setting. Ergonomics pp. 1-38. 10.1080/00140139.2017.1330491 .

http://ift.tt/2rFh5BA

Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial.

Sivaprasad, S; Prevost, AT; Vasconcelos, JC; Riddell, A; Murphy, C; Kelly, J; Bainbridge, J; Sivaprasad, S; Prevost, AT; Vasconcelos, JC; Riddell, A; Murphy, C; Kelly, J; Bainbridge, J; Tudor-Edwards, R; Hopkins, D; Hykin, P; CLARITY Study Group, ; - view fewer (2017) Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial. Lancet 10.1016/S0140-6736(17)31193-5 .

http://ift.tt/2qGSoYc

Clinically significant depressive symptoms and sexual behaviour among men who have sex with men.

Miltz, AR; Rodger, AJ; Sewell, J; Speakman, A; Phillips, AN; Sherr, L; Gilson, RJ; Miltz, AR; Rodger, AJ; Sewell, J; Speakman, A; Phillips, AN; Sherr, L; Gilson, RJ; Asboe, D; Nwokolo, NC; Clarke, A; Gompels, MM; Allan, S; Collins, S; Lampe, FC; AURAH Study Group, ; - view fewer (2017) Clinically significant depressive symptoms and sexual behaviour among men who have sex with men. BJPsych Open , 3 (3) pp. 127-137. 10.1192/bjpo.bp.116.003574 .

http://ift.tt/2rFhQdP

5-Aminosalicylates promote inflammation resolution in ulcerative colitis through generation of anti-inflammatory hydroxy fatty acids

Wysoczanski, R; Kendall, A; Motwani, M; Vega, R; Rahman, F; McCartney, S; Bloom, S; Wysoczanski, R; Kendall, A; Motwani, M; Vega, R; Rahman, F; McCartney, S; Bloom, S; Nicolaou, A; Gilroy, D; Segal, A; Marks, D; - view fewer (2017) 5-Aminosalicylates promote inflammation resolution in ulcerative colitis through generation of anti-inflammatory hydroxy fatty acids. In: (pp. S100-S101). OXFORD UNIV PRESS

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