Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.
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Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Πέμπτη 4 Αυγούστου 2016
The global antigenic diversity of swine influenza A viruses
Genetic adaptation of influenza A viruses in domestic animals and their potential role in interspecies transmission: a literature review
In December 2011, the European Food Safety Authority awarded a Grant for the implementation of the FLURISK project. The main objective of FLURISK was the development of an epidemiological and virological evidence-based influenza risk assessment framework (IRAF) to assess influenza A virus strains circulating in the animal population according to their potential to cross the species barrier and cause infections in humans. With the purpose of gathering virological data to include in the IRAF, a literature review was conducted and key findings are presented here. Several adaptive traits have been identified in influenza viruses infecting domestic animals and a significance of these adaptations for the emergence of zoonotic influenza, such as shift in receptor preference and mutations in the replication proteins, has been hypothesized. Nonetheless, and despite several decades of research, a comprehensive understanding of the conditions that facilitate interspecies transmission is still lacking. This has been hampered by the intrinsic difficulties of the subject and the complexity of correlating environmental, viral and host factors. Finding the most suitable and feasible way of investigating these factors in laboratory settings represents another challenge. The majority of the studies identified through this review focus on only a subset of species, subtypes and genes, such as influenza in avian species and avian influenza viruses adapting to humans, especially in the context of highly pathogenic avian influenza H5N1. Further research applying a holistic approach and investigating the broader influenza genetic spectrum is urgently needed in the field of genetic adaptation of influenza A viruses.
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Duality of β-glucan microparticles: antigen carrier and immunostimulants
Designing efficient recombinant mucosal vaccines against enteric diseases is still a major challenge. Mucosal delivery of recombinant vaccines requires encapsulation in potent immunostimulatory particles to induce an efficient immune response. This paper evaluates the capacity of beta-glucan microparticles (GPs) as antigen vehicles and characterizes their immune-stimulatory effects. The relevant infectious antigen FedF was chosen to be loaded inside the microparticles. The incorporation of FedF inside the particles was highly efficient (roughly 85%) and occurred without antigen degradation. In addition, these GPs have immunostimulatory effects as well, demonstrated by the strong reactive oxygen species (ROS) production by porcine neutrophils upon their recognition. Although antigen-loaded GPs still induce ROS production, antigen loading decreases this production by neutrophils for reasons yet unknown. However, these antigen-loaded GPs are still able to bind their specific beta-glucan receptor, demonstrated by blocking complement receptor 3, which is the major beta-glucan receptor on porcine neutrophils. The dual character of these particles is confirmed by a T-cell proliferation assay. FedF-loaded particles induce a significantly higher FedF-specific T-cell proliferation than soluble FedF. Taken together, these results show that GPs are efficient antigen carriers with immune-stimulatory properties.
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Complex odontomas hindering eruption of maxillary permanent teeth: a radiological perspective
Description
Odontomas are benign neoplasms of odontogenic origin. They are more appropriately termed hamartomas because of their limited growth potential rather than true neoplasm. Clinically, three types of odontomas are identified in the literature: central (intraosseous) odontoma, peripheral (extraosseous or soft tissue) odontoma and erupted odontoma, whereas histologically they can be either compound (tooth-like structures) or complex (mixture of odontogenic tissues without dental organisation).1
These odontomas although benign cause disturbances in tooth eruption, such as impaction, delayed eruption or retention of primary teeth.2
Case reportA 12-year-old girl reported to the clinic for routine dental check-up. Her medical, dental and family histories were insignificant. Oral examination revealed mixed dentition with presence of over-retained maxillary deciduous teeth 62, 63 and 64(FDI) in the left quadrant. An orthopantomogram was advised and it revealed unerupted permanent successors 22, 23 and 24 associated with a mixed radiopaque-radiolucent...
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Miscarriage following dengue virus 3 infection in the first six weeks of pregnancy of a dengue virus-naive traveller returning from Bali to Italy, April 2016
We report miscarriage following dengue virus (DENV)-3 infection in a pregnant woman returning from Bali to Italy in April 2016. On her arrival, the woman had fever, rash, asthenia and headache. DENV RNA was detected in plasma and urine samples collected the following day. Six days after symptom onset, she had a miscarriage. DENV RNA was detected in fetal material, but in utero fetal infection cannot be demonstrated due to possible contamination by maternal blood.
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Brucellosis in a refugee who migrated from Syria to Germany and lessons learnt, 2016
A teenage woman migrating from Syria arrived in May 2015 in Germany. She gave birth to a healthy child in early 2016, but became febrile shortly after delivery. Blood cultures revealed Brucella melitensis. In retrospect, she reported contact with sheep in Syria and recurrent pain in the hip joints over about five months before diagnosis of brucellosis. We discuss consequences for adequate treatment of mother and child as well as for clinical and laboratory management.
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Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case-control study, February 2013 to July 2014
Strongyloides stercoralis is a soil-transmitted helminth widely diffused in tropical and subtropical regions of the world. Autochthonous cases have been also diagnosed sporadically in areas of temperate climate. We aimed at defining the epidemiology of strongyloidiasis in immigrants and Italians living in three northern Italian Regions. Screening for S. stercoralis infection was done with serology, confirmation tests were a second serological method or stool agar culture. A case-control approach was adopted and patients with a peripheral eosinophil count???500/mcL were classified as cases. Of 2,701 individuals enrolled here 1,351 were cases and 1,350 controls; 86% were Italians, 48% women. Italians testing positive were in 8% (97/1,137) cases and 1% (13/1,178) controls (adjusted odds ratio (aOR) 8.2; 95% confidence interval (CI): 4.5-14.8), while positive immigrants were in 17% (36/214) cases and in 2% (3/172) controls (aOR 9.6; 95% CI: 2.9-32.4). Factors associated with a higher risk of infection for all study participants were eosinophilia (p?<?0.001) and immigration (p?=?0.001). Overall, strongyloidiasis was nine-times more frequent in individuals with eosinophilia than in those with normal eosinophil count.
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Estimating the economic impact of a possible equine and human epidemic of West Nile virus infection in Belgium
This study aimed at estimating, in a prospective scenario, the potential economic impact of a possible epidemic of WNV infection in Belgium, based on 2012 values for the equine and human health sectors, in order to increase preparedness and help decision-makers. Modelling of risk areas, based on the habitat suitable for Culex pipiens, the main vector of the virus, allowed us to determine equine and human populations at risk. Characteristics of the different clinical forms of the disease based on past epidemics in Europe allowed morbidity among horses and humans to be estimated. The main costs for the equine sector were vaccination and replacement value of dead or euthanised horses. The choice of the vaccination strategy would have important consequences in terms of cost. Vaccination of the country's whole population of horses, based on a worst-case scenario, would cost more than EUR 30 million; for areas at risk, the cost would be around EUR 16-17 million. Regarding the impact on human health, short-term costs and socio-economic losses were estimated for patients who developed the neuroinvasive form of the disease, as no vaccine is available yet for humans. Hospital charges of around EUR 3,600 for a case of West Nile neuroinvasive disease and EUR 4,500 for a case of acute flaccid paralysis would be the major financial consequence of an epidemic of West Nile virus infection in humans in Belgium.
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UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3[beta]/[beta]-catenin pathway in hepatocellular carcinoma cells.
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Reactive oxygen species contribute toward Smac mimetic/temozolomide-induced cell death in glioblastoma cells .
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Suberanilohydroxamic acid (vorinostat) synergistically enhances the cytotoxicity of doxorubicin and cisplatin in osteosarcoma cell lines.
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Analyte-Directed Formation of Emissive Excimers for the Selective Detection of Polyamines
DOI: 10.1039/C6CC05761F, Communication
A convenient and selective method for the sensing of polyamines, which are important biomarkers for cancers, has been developed. The fluorescence light-up mechanism utilizes the analyte-induced formation of emissive excimers...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Crystalline anionic complex of scandium nitride endometallo-fullerene: Experimental observation of single-bonded (Sc3N@Ih-C80-)2 dimers
DOI: 10.1039/C6CC05550H, Communication
Reduction of scandium nitride clusterfullerene, Sc3N@Ih-C80, by sodium fluorenone ketyl in the presence of cryptand[2,2,2] allows the crystallization of the {cryptand[2,2,2](Na+)}2(Sc3N@Ih-C80-)2 2.5C6H4Cl2 (1) salt. The Sc3N@Ih-C80.- radical anions are dimerized...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Race and mortality risk after radiation therapy in men treated with or without androgen-suppression therapy for favorable-risk prostate cancer
BACKGROUND
African American (AA) men are more likely than non-AA men to have a comorbid illness that could interact with androgen-deprivation therapy (ADT) and shorten survival. This study assessed the impact that race had on the risk of all-cause mortality (ACM) and other-cause mortality (OCM) among men definitively treated for favorable-risk prostate cancer (PC).
METHODS
Between 1997 and 2013, 7252 men with low-risk or favorable intermediate-risk PC were treated with brachytherapy with neoadjuvant ADT (n = 1501) or without neoadjuvant ADT (n = 5751) for a 4-month median duration. Cox and Fine-Gray multivariate regressions were used to analyze whether the risk of ACM and OCM increased among AA men versus non-AA men receiving ADT; adjustments were made for the age at brachytherapy, year of brachytherapy, cardiometabolic comorbidity status, risk group, and ADT treatment propensity score.
RESULTS
After a median follow-up of 8.04 years, 869 men (12.0%) died: 48 (5.52%) of PC and 821 (94.48%) of other causes. There was a significant association between AA race and an increased risk of both ACM (adjusted hazard ratio [AHR], 1.77; 95% confidence interval [CI], 1.06-2.94; P = .028) and OCM (AHR, 1.86; 95% CI, 1.08-3.19; P = .024) among AA men versus non-AA men who received ADT but not among those who did not receive ADT (AHR for ACM, 1.33; 95% CI, 0.93-1.91; P = .12; AHR for OCM, 1.39; 95% CI, 0.96-2.02; P = .08).
CONCLUSIONS
ADT use may shorten survival in AA men with favorable-risk PC; therefore, its reservation for the treatment of higher risk PC, for which level 1 evidence supports its use, should be considered. Cancer 2016. © 2016 American Cancer Society.
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Visualization of the airway in infants with MRI using pointwise encoding time reduction with radial acquisition (PETRA)
Purpose
To assess airway visibility in infants using pointwise encoding time reduction with radial acquisition (PETRA).
Materials and Methods
PETRA was obtained in 37 infants (gestational age: 23–43 weeks; postconceptional age: 34–46 weeks) using 3T magnetic resonance imaging (MRI) without respiratory gating. The visibility of the branching point and the airway structures, including the trachea and bronchi, on PETRA was scored by two experienced pediatric radiologists using a four-point scale (0–3). The rates of good visibility (score 3 or 2) were calculated for each airway structure. Interrater agreement was evaluated by intraclass correlation coefficient (ICC).
Results
For readers 1 and 2, good visibility was achieved for the branching point of the main bronchi (76% and 95%, respectively), trachea (97% and 95%, respectively), right main bronchus (92% and 92%, respectively), and left main bronchus (97% and 84%, respectively). Lower rates of visibility were achieved for the lobar bronchi. There was substantial agreement (ICC: 0.61–0.79) between the two readers for all the airway structures, except for the branching point at the right upper/middle lobe bronchi, for which there was moderate agreement (ICC: 0.56).
Conclusion
PETRA has the potential for good airway visibility in infants, particularly for the trachea and main bronchi. J. Magn. Reson. Imaging 2016
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Morphological and dynamic contrast enhanced MR imaging features for the differentiation of chordoma and giant cell tumors in the Axial Skeleton
Purpose
To characterize the morphological and dynamic-contrast-enhanced (DCE) MRI features of chordoma and giant cell tumor (GCT) of bone occurring in the axial skeleton.
Materials and Methods
A total of 13 patients with chordoma and 26 patients with GCT who received conventional T1, T2, and DCE-MRI on 3 Tesla MR scanners were retrospectively identified and analyzed. Two radiologists evaluated morphological features independently, including the lesion location, expansile bone changes, vertebral compression, presence of paraspinal soft tissue mass, fibrous septa, and the signal intensity on T1WI and T2WI. The inter-observer agreement was evaluated by kappa test. The DCE kinetics was measured to obtain the initial area under curve (IAUC) and the wash-out slope; also the two-compartmental pharmacokinetic model was applied to obtain Ktrans and kep. The diagnostic accuracy was evaluated by CHAID decision tree and ROC analysis.
Results
Chordomas were more likely to show soft tissue mass than GCTs (13/13 = 100% versus 15/26 = 58%; P = 0.007), as well as fibrous septa (9/13 = 69% versus 0; P < 0.001). In decision tree analysis, presence of fibrous septa and lesion location yield 31/39 = 79% accuracy. The DCE-MRI pharmacokinetic parameters Ktrans and kep of GCTs were significantly higher than those of chordomas, 0.13 ± 0.65 versus 0.06 ± 0.04 (1/min) for Ktrans, 0.62 ± 0.22 versus 0.17 ± 0.12 (1/min) for kep, P < 0.001 for both. If using kep = 0.43/min as the cut-off value, it achieved 100% sensitivity and 92% specificity to differentiate chordoma from GCT, with an overall accuracy of 37/39 = 95%. The IAUC was highly correlated with Ktrans (r = 0.94), and the slope was highly correlated with kep (r = 0.95).
Conclusion
Several morphological features were significantly different between chordoma and GCT, but their diagnostic performance was inferior to that of DCE-MRI. J. Magn. Reson. Imaging 2016
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Susceptibility assay of Haemonchus contortus to commonly used anthelmintics in Jimma, southwest Ethiopia
An experimental study to investigate the susceptibility pattern of Haemonchus contortus to commonly used anthelmintics (albendazole, tetramisole, ivermectin, and triclobendazole) was conducted between June and September 2009. Adult H. contortus parasites were collected from a total of 30 sheep slaughtered at Jimma municipal abattoir. The anthelmintics were assessed for egg hatch inhibition ability against H. contortus eggs. The eggs (500 eggs/ml) were incubated with different concentrations (0.25, 0.125, 0.0625, 0.03125, and 0.015625 mu g/ml) at 26A degrees C for 48 h. Egg hatching inhibition of different anthelmintics at different concentrations was recorded. The overall mean percent inhibition showed that there was a significant difference (p < 0.05) among the different concentrations. Mean egg hatch inhibition of ivermectin showed the highest result (84.90 %) at 0.25 mu g/ml, followed by albendazole (78.77 %), triclobendazole (76.66 %), and tetramisole (78.98 %), respectively. The overall mean percent inhibition showed a significant difference (p < 0.05) among the different anthelmintics. Further evaluation of these anthelmintics was recommended.
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Nonpharmacological Treatment Approach to Pain
2016-08-04T07-16-21Z
Source: The Journal of Neurobehavioral Sciences
Selin Özcan, Gökben Hızlı Sayar, Nevzat Tarhan.
Chronic pain has various forms such as inflammatory pain, visceral pain, headache, disk-related pain, neuropathic pain, cancer pain. Although the biological basis of chronic pain is related to vulnerability, it continues with behavioral and psychological components. In the context of multimodal interventions, interventions other than systemic pharmacologic treatments for chronic pain are also present. Besides interventional approaches; there are several noninvasive options including cognitive behavioral therapy, biofeedback, relaxation therapy, physical therapy, thermal applications, spinal cord stimulation and transcutaneous electrical stimulation. The neuroscientific approach to pain can only be achieved by combining physical and mental components of the pain with neuroscience
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Sertraline induced tremor
2016-08-04T07-16-21Z
Source: The Journal of Neurobehavioral Sciences
N.A. UVAIS, V.S. SREERAJ.
Specific serotonin reuptake inhibitors have been associated with extrapyramidal dysfunction manifesting as parkinsonism, dystonia, tremor, and akathisia. Here, we describe a old female patient with a diagnosis of moderate depressive episode who developed tremor with sertraline in the absence of concurrent prescription of medications, which have potential action on the dopaminergic system and whose symptoms resolved after the drug was discontinued.
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Outcome analysis of ventriculoperitoneal shunt procedures in hydrocephalus due to tubercular meningitis and non-infective cases
2016-08-04T07-08-55Z
Source: International Journal of Contemporary Pediatrics
Devendra K. Tyagi, Srikant Balasubramaniam, Shalika A. Jayaswal, Hemant V. Savant, Anish S. Gandhi.
Background: Hydrocephalus is one of the most common clinical conditions affecting the central nervous system. There have been several studies which show that the outcome of VP shunt in tubercular meningitis hydrocephalus is worse. We have conducted the present study to find whether VP shunt procedure complication rates are different in these two sub class patients or if the prognosis in TBM patients is worse due to the primary disease process. Methods: Ours is a retrospective analysis conducted in a tertiary care centre of 50 patients each of hydrocephalus due to tubercular meningitis (TBM) and non-meningitis patients. The data was collected over a period of 3 years. The diagnosis of tubercular meningitis was established by clinical history with examination, cerebrospinal Fluid (CSF) analysis and computed tomography brain (CT - Plain and contrast). All patients underwent Ventriculo Peritoneal shunt (VPS) in a standard protocol. All patients of TBM were put on 4 drugs anti Kochs treatment (AKT) for 3 months and 2 drugs AKT for 1 year. The follow up ranged between 3 years to 6 years. Results: Data in the form of age, sex, clinical signs/symptoms and shunt related complications were noted in a prescribed format. The complications in the two groups were statistically compared for significance using p value. Conclusions: There is no statistically significant increase in complication rate of VP shunt in TBM patients versus non infective cases. The worse prognosis of TBM patients may probably be due to the primary disease process rather than functioning of shunt.
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Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice
Essers, P; Tain, LS; Nespital, T; Goncalves, J; Froehlich, J; Partridge, L; (2016) Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice. Scientific Reports , 6 , Article 30290. 10.1038/srep30290 . Green open access
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An investigation of the acute and chronic effects of ketamine on cognition.
Morgan, C.J.A.; (2006) An investigation of the acute and chronic effects of ketamine on cognition. Doctoral thesis, University of London. Green open access
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Prediction and qualitative assessment of five-and six-year-old children's reading: a longitudinal study
Stuart, M; (1995) Prediction and qualitative assessment of five-and six-year-old children's reading: a longitudinal study. British Journal of Educational Psychology , 65 (3) pp. 287-296. 10.1111/j.2044-8279.1995.tb01150.x .
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Apprehensions of time: Michelangelo Antonioni and experimental cinema, 1960-1975.
Nardelli, M.; (2006) Apprehensions of time: Michelangelo Antonioni and experimental cinema, 1960-1975. Doctoral thesis, University of London. Green open access
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Spongelike acquisition of sight vocabulary in beginning readers?
Stuart, M; Masterson, J; Dixon, M; (2000) Spongelike acquisition of sight vocabulary in beginning readers? Journal of Research in Reading , 23 (1) pp. 12-27. 10.1111/1467-9817.00099 .
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An investigation of the mechanisms underlying hypotension and vascular hyporeactivity in septic shock.
O'Brien, A.; (2006) An investigation of the mechanisms underlying hypotension and vascular hyporeactivity in septic shock. Doctoral thesis, University of London. Green open access
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Getting ready for reading: Early phoneme awareness and phonics teaching improves reading and spelling in inner-city second language learners
Stuart, M; (1999) Getting ready for reading: Early phoneme awareness and phonics teaching improves reading and spelling in inner-city second language learners. British Journal of Educational Psychology , 69 (4) pp. 587-605. 10.1348/000709999157914 .
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Measurement of the charge asymmetry in highly boosted top-quark pair production in root s=8 TeV pp collision data collected by the ATLAS experiment
Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Abeloos, B; Aben, R; Abolins, M; Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Abeloos, B; Aben, R; Abolins, M; AbouZeid, OS; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, BS; Adamczyk, L; Adams, DL; Adelman, J; Adomeit, S; Adye, T; Affolder, AA; Agatonovic-Jovin, T; Agricola, J; Aguilar-Saavedra, JA; Ahlen, SP; Ahmadov, F; Aielli, G; Akerstedt, H; Akesson, TPA; Akimov, AV; Alberghi, GL; Albert, J; Albrand, S; Alconada Verzini, MJ; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alison, J; Alkire, SP; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Gonzalez, BA; Alvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amako, K; Coutinho, YA; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, G; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, AV; Anjos, N; Annovi, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; Arce, ATH; Arduh, FA; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, AJ; Armitage, LJ; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, NB; Augsten, K; Avolio, G; Axen, B; Ayoub, MK; Azuelos, G; Baak, MA; Baas, AE; Baca, MJ; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagiacchi, P; Bagnaia, P; Bai, Y; Baines, JT; Baker, OK; Baldin, EM; Balek, P; Balestri, T; Balli, F; Balunas, WK; Banas, E; Banerjee, S; Bannoura, AAE; Barak, L; Barberio, EL; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnes, SL; Barnett, BM; Barnett, RM; Barnovska, Z; Baroncelli, A; Barone, G; Barr, AJ; Barranco Navarro, L; Barreiro, F; da Costa, JBG; Bartoldus, R; Barton, AE; Bartos, P; Basalaev, A; Bassalat, A; Basye, A; Bates, RL; Batista, SJ; Batley, JR; Battaglia, M; Bauce, M; Bauer, F; Bawa, HS; Beacham, JB; Beattie, MD; Beau, T; Beauchemin, PH; Beccherle, R; Bechtle, P; Beck, P; Becker, K; Becker, M; Beckingham, M; Becot, C; Beddall, AJ; Beddall, A; Bednyakov, VA; Bedognetti, M; Bee, CP; Beemster, LJ; Beermann, TA; Begel, M; Behr, JK; Belanger-Champagne, C; Bell, AS; Bell, WH; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Belyaev, NL; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, EB; Benitez, J; Garcia, JAB; Benjamin, DP; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Berghaus, F; Beringer, J; Berlendis, S; Bernard, C; Bernard, NR; Bernius, C; Bernlochner, FU; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertram, IA; Bertsche, C; Bertsche, D; Besjes, GJ; Bylund, OB; Bessner, M; Besson, N; Betancourt, C; Bethke, S; 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Zwalinski, L; ATLAS Collaboration, .; - view fewer (2016) Measurement of the charge asymmetry in highly boosted top-quark pair production in root s=8 TeV pp collision data collected by the ATLAS experiment. Physics Letters B , 756 pp. 52-71. 10.1016/j.physletb.2016.02.055 . Green open access
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'The ICECAP-SCM tells you more about what I'm going through': A think-aloud study measuring quality of life among patients receiving supportive and palliative care
Bailey, C; Kinghorn, P; Orlando, R; Armour, K; Perry, R; Jones, L; Coast, J; Bailey, C; Kinghorn, P; Orlando, R; Armour, K; Perry, R; Jones, L; Coast, J; Jones, CL; - view fewer (2016) 'The ICECAP-SCM tells you more about what I'm going through': A think-aloud study measuring quality of life among patients receiving supportive and palliative care. Palliative Medicine , 30 (7) pp. 642-652. 10.1177/0269216315624890 . Green open access
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An investigation into the scale-free nature of heterogenous networks.
Spencer, J.J.L.; (2007) An investigation into the scale-free nature of heterogenous networks. Doctoral thesis, University of London. Green open access
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An empirical study investigating the role of child-mother attachment security in predicting children's responses to the arrival of a sibling.
Hamilton, V.; (2007) An empirical study investigating the role of child-mother attachment security in predicting children's responses to the arrival of a sibling. Doctoral thesis, University of London. Green open access
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SAPS_EX1/2_RAW
Garside, DJ; MacDonald, L; Tuenissen, K; Robson, S; (2016) SAPS_EX1/2_RAW. [Dataset]. Department of Civil, Environmental and Geomatic Engineering, University College London (University College London (UCL CEGE): AIC 2016. Green open access
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Hybrid Binary Imperialist Competition Algorithm and Tabu Search Approach for Feature Selection Using Gene Expression Data
Gene expression data composed of thousands of genes play an important role in classification platforms and disease diagnosis. Hence, it is vital to select a small subset of salient features over a large number of gene expression data. Lately, many researchers devote themselves to feature selection using diverse computational intelligence methods. However, in the progress of selecting informative genes, many computational methods face difficulties in selecting small subsets for cancer classification due to the huge number of genes (high dimension) compared to the small number of samples, noisy genes, and irrelevant genes. In this paper, we propose a new hybrid algorithm HICATS incorporating imperialist competition algorithm (ICA) which performs global search and tabu search (TS) that conducts fine-tuned search. In order to verify the performance of the proposed algorithm HICATS, we have tested it on 10 well-known benchmark gene expression classification datasets with dimensions varying from 2308 to 12600. The performance of our proposed method proved to be superior to other related works including the conventional version of binary optimization algorithm in terms of classification accuracy and the number of selected genes.
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Toluene down-regulates filaggrin expression via the ERK and STAT3 – dependent pathways
Source:Journal of Allergy and Clinical Immunology
Author(s): Hana Lee, Jung Jin Shin, Hyun Cheol Bae, Woo-In Ryu, Sang Wook Son
Teaser
We investigated the effect of toluene on the skin barrier. The present study suggests that toluene may contribute to epidermal barrier dysfunction through down-regulation of filaggrin expression by the STAT3 and ERK1/2 signaling pathway.from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2aLawaA
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Common peptide epitopes induce cross-reactivity in hypersensitivity pneumonitis serodiagnosis
Source:Journal of Allergy and Clinical Immunology
Author(s): L. Millon, B. Rognon, B. Valot, C. Barrera, A.P. Bellanger, S. Roussel, J.D. Dalphin, M. Monod, G. Reboux
Teaser
The identification of common epitopes in orthologous immunogenic proteins from two microorganisms belonging to very different phylogenetic families, each involved in a specific form of HP, could help in developing new diagnostic and therapeutic strategies.from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2axoUGO
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Network dynamics in dyslexia: Review and implications for remediation
Publication date: December 2016
Source:Research in Developmental Disabilities, Volume 59
Author(s): John R. Kershner
Extant neurobiological theories of dyslexia appear fractional in focusing on isolated brain regions, mechanisms, and functional pathways. A synthesis of current research shows support for an Interactive Specialization (IS) model of dyslexia involving the dysfunctional orchestration of a widely-distributed, attentionally-controlled, hierarchical, and interhemispheric circuit of intercommunicating neuronal networks. This circuitry is comprised principally of the frontostriatal-parietal cognitive control system of networks, the posterior corpus callosum, and the left arcuate fasciculus. During development, the coalescence of these functionally specialized regions, acting together, may be essential to preventing the core phonemic and phonological processing deficits defining the dyslexic phenotype. Research demonstrating an association of each with processing phonology presents the foundational outline for a comprehensive, integrative theory of dyslexia and suggests the importance of inclusive remedial efforts aimed at promoting interactions among all three networking territories.
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Aiding the diagnosis of AD/HD in childhood: Using actigraphy and a continuous performance test to objectively quantify symptoms
Publication date: December 2016
Source:Research in Developmental Disabilities, Volume 59
Author(s): Hannah Gilbert, Ling Qin, Dandan Li, Xuehua Zhang, Stuart J. Johnstone
The current gold standard for the diagnosis of AD/HD is based on subjective reports from teachers, parents, and clinicians. These measures can be problematic as they are open to rater biases and also fail to account for the developmental nature of symptoms. The current study examined the diagnostic accuracy of two objective measures, a computer-based Continuous Performance Task and actigraphy (e.g. motion tracking device) in differentiating children with AD/HD (N=70) from healthy controls (N=70). It was predicted that task-unrelated movement (measured via actigraphy) during a CPT and CPT performance would have high classification accuracy in differentiating children with AD/HD from healthy controls, and that the inclusion of age would increase this accuracy. Results indicated that total energy expenditure from the task-unrelated wrist and ankle movement during the CPT was higher in children with AD/HD than controls, and that CPT performance was poorer in AD/HD than controls. Discriminant function analyses revealed that the CPT Full-Scale Response Control Quotient and wrist and ankle energy expenditure provided optimal classification accuracy – correctly classifying 86% of cases, with sensitivity of 81.4% and specificity of 91.4%. The prediction that classification accuracy would increase with the inclusion of age was not supported by the data. When taken in conjunction with other clinical assessments, these findings suggest that actigraphy during a CPT and CPT performance may increase the probability of a correct AD/HD diagnosis.
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