Reply to the letter regarding NADPH oxidase inhibitor

https://ift.tt/2QyMG4Q

Practical guide for the management of systemic toxicity caused by local anesthetics

Abstract

Systemic toxicity from local anesthetics can occur in any of the wide range of situations in which these agents are used. This practical guide is created to generate a shared awareness of the prevention, diagnosis, and treatment of local anesthetic systemic toxicity among all medical professionals who perform nerve blocks. Systemic toxicity of local anesthetic is induced by an increase of its protein-unbound plasma concentration. Initial symptoms are characterized by central nervous system signs such as excitation, convulsions, followed by loss of consciousness and respiratory arrest. These symptoms are often accompanied with cardiovascular signs such as hypertension, tachycardia and premature ventricular contractions. Further increase of plasma concentration of local anesthetic induces bradycardia, conduction disturbances, circulatory collapse and asystole. The incidence of local anesthetic systemic toxicity is 1–11 cases per 10,000. Infants, patients with decreased liver function and low cardiac output are vulnerable to systemic toxicity. When performing regional anesthesia, the guideline-directed monitoring, securing a venous line, preparation of medication to treat convulsions and lipid emulsions are required. For prevention of local anesthetic systemic toxicity, small-dose, divided administration, using agents with low toxicity such as ropivacaine and levobupivacaine, performing an aspiration test are recommended. If systemic toxicity is suspected, halt administration of local anesthetic, request assistance, secure venous line, airway, administration of 100% oxygen and if necessary tracheal intubation and artificial respiration should be immediately performed. Benzodiazepines are recommended to treat convulsions. Administration of 20% lipid emulsion according to the protocol is recommended to treat severe hypotension and arrhythmia.

https://ift.tt/2PjDxAB

High‐risk symptoms do not predict gastric cancer precursors

Abstract

Background & Study Aims

Gastric intestinal metaplasia (GIM) is the most common precursor of gastric cancer. Our aim is to determine if presenting symptoms predict gastric cancer precursor lesions in a high‐risk population.

Patient and Methods

Consecutive unique patients evaluated by endoscopy for upper gastrointestinal symptoms at the Los Angeles County Hospital between 2010 and 2014 were evaluated. Presenting symptoms were classified as low‐ or high‐risk depending on the procedure indication as coded using the Clinical Outcomes Research Initiative (CORI) system. Endoscopy and histology results were used to classify findings as benign, GIM, high‐risk GIM, or malignant. The primary outcome was the proportion of patients with premalignant or malignant gastric findings who had high‐risk clinical indications for endoscopy relative to those with benign results.

Results

A total of 3699 patients underwent endoscopy to evaluate upper gastrointestinal symptoms. There were 373 (10.1%) patients with GIM of which 278 had high‐risk GIM. One hundred and sixty (4.3%) patients were diagnosed with gastric cancer. High‐risk indications for upper endoscopy predicted gastric cancer (OR 1.8 [95% CI 1.3‐2.6]) but not GIM (OR 1.0 [0.8‐1.3]) or high‐risk GIM (OR 0.9 [0.7‐1.2]). Hispanic or Asian patients and patients >50 years old were more likely to have GIM, high‐risk GIM, and cancer.

Conclusions

Performance of upper endoscopy for high‐risk indications is inadequate to detect GIM and marginal for malignancy. At risk patients should undergo upper endoscopy for both low‐ and high‐risk symptoms. Screening certain populations deserve additional study and may, in fact, be cost‐effective.

https://ift.tt/2AZcLEW

Extragastric diseases correlated with Helicobacter pylori

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Issue Information

https://ift.tt/2PR007s

Hypopyon pustules of Sneddon‐Wilkenson disease

https://ift.tt/2DeTErW

A case of Kindler syndrome in a young Indian female with exon deletion

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Multidermatomal zosteriform lichen planus pigmentosus–a unique presentation

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Interventions for infantile haemangiomas of the skin: abridged Cochrane systematic review including GRADE assessments

Summary

Infantile haemangiomas (IH) are soft swellings of the skin that occur in 3‐10% of infants. When haemangiomas occur in high‐risk areas or when complications develop, active intervention is necessary. This is an update of a Cochrane Review assessing the interventions for the management of IH in children. We searched for randomized controlled trials in CENTRAL, MEDLINE, Embase, LILACS, AMED, PsycINFO, CINAHL and six trials registers to February 2017. We included 28 trials (1728 participants) assessing 12 interventions. We downgraded evidence from high to moderate/low for issues related to risk of bias and imprecision. Oral propranolol (3 mg/kg/day) probably improves clinician‐assessed clearance compared to placebo (risk ratio (RR) 16·61, 95% confidence interval (CI) 4·22 to 65·34; moderate quality of evidence (QoE)); we found no evidence of a difference in terms of serious adverse events (RR 1·05, 95% CI 0·33 to 3·39; low QoE). We found the chance of reduction of redness may be improved with topical timolol maleate (0·5% gel applied twice daily) when compared to placebo (RR 8·11, 95% CI 1·09 to 60·09; low QoE). We found no instances of bradycardia or hypotension for this comparison. Our key results indicate that oral propranolol and topical timolol maleate are more beneficial than placebo in terms of clearance or other measures of resolution, or both, without an increase in harms.

This article is protected by copyright. All rights reserved.

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Psoriasis in a cohort of patients with common variable immunodeficiency

Abstract

Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency in adults. CVID is characterized by reduced serum levels of IgG, IgA, and/or IgM, recurrent bacterial infections, autoimmune and inflammatory diseases and malignancies. According to literature, autoimmune diseases occur in 20–30% of CVID patients. Dermatological involvement has occasionally been reported in CVID and includes alopecia totalis, lichen planus, and vitiligo. Data regarding the frequency and features of psoriasis in CVID are scant.

This article is protected by copyright. All rights reserved.

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A Case of Acute Pemphigus Vulgaris Relapses Associated with Cocaine Use and Review of the Literature

Abstract

Pemphigus is a bullous autoimmune disease that affects the skin and mucous membranes. It is very difficult to establish the etiology and the triggering factors that influence reactivations in pemphigus vulgaris (PV). The case of a 33-year-old male with chronic history of intranasal cocaine consumption is presented in this report. We present the clinical case of the patient, followed for a total of 86 weeks, with ten relapses secondary to probable cocaine use. The patient was admitted to the emergency department after presenting polymorphic dermatosis characterized by blisters, vesicles, and excoriations extending from the oral cavity to the thorax, and to the inguinal and genital regions, affecting approximately 35 % of the body surface area with a score of 56 on the Pemphigus Skin Disorder Index. Skin biopsies were compatible with PV diagnosis. The patient had clinical improvement with a combination of methylprednisolone 500 mg intravenously (IV) and cyclophosphamide 500 mg IV every 15 days, along with prednisone 50 mg orally (PO) q24 h and mycophenolic acid 500 mg PO q6 h. Persistent cocaine use is highly likely to be the factor triggering lesion reactivation and responsible for the torpid evolution. We cannot definitively conclude whether the change from azathioprine to mycophenolic acid after the tenth relapse was the adjuvant medication responsible for the end of the consolidation phase and complete remission on therapy. This case study could potentially serve as a guide for management of patients who continuously persist with cocaine use, leading to a clinical picture refractory to multiple therapeutic schemes.

https://ift.tt/2PoGjEL

Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctivitis

Publication date: Available online 9 November 2018

Source: Allergology International

Author(s): Yosuke Asada, Mikiko Okano, Waka Ishida, Satoshi Iwamoto, Ken Fukuda, Toshiaki Hirakata, Norihiro Tada, Atsuki Fukushima, Nobuyuki Ebihara, Akira Kudo, Akira Matsuda

Abstract

Background

To investigate the potential roles of periostin (POSTN), an extracellular matrix preferentially expressed in Th2-skewed conditions in the pathophysiology of allergic conjunctivitis.

Methods

The roles of POSTN in ragweed-induced experimental allergic conjunctivitis (RW-EAC) were evaluated using both POSTN-knockout (KO) and congenic BALB/c wild-type mice. Histological analysis was carried out to enumerate eosinophils/basophils in the conjunctival tissue. Th2 cytokine expression was evaluated by quantitative polymerase chain reaction (Q-PCR), and microarray analysis was performed to elucidate genes differentially expressed in POSTN-KO and wild-type mice in the RW-EAC model.

Results

Upregulation of POSTN expression and eosinophil infiltration was observed in subconjunctival tissue of RW-EAC in the wild-type mice. The number of infiltrating eosinophils in the conjunctivae of RW-EAC was diminished in POSTN-KO mice compared to wild-type mice. Q-PCR analysis of conjunctival tissue showed induction of Th2 cytokine (Ccl5, Il4, Il5, Il13) expression in the RW-EAC and attenuated Ccl5, Il4, Il13 mRNA expression in the conjunctivae of the RW-EAC using POSTN-KO mice. Microarray analysis and immunohistochemical analysis showed diminished basophil marker (Mcpt8) expression and reduced numbers of infiltrating basophils in the conjunctivae of RW-EAC in POSTN-KO mice.

Conclusions

POSTN expression in conjunctival tissue plays an indispensable role in the late-phase reaction of the RW-EAC model by facilitating eosinophil/basophil infiltration and augmenting Th2 cytokine expression.

https://ift.tt/2Dd3Dhk

Contents

Publication date: December 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 6

Author(s):

https://ift.tt/2DdO7Sc

Editorial Board

Publication date: December 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 6

Author(s):

https://ift.tt/2PNJTrk

Endoscopic lateralization of the vocal fold

Publication date: Available online 9 November 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): C. Fabre, C.A. Righini, P.F. Castellanos, I. Atallah

Abstract

Vocal fold paralysis in adduction can result in significant breathing difficulties. Techniques such as vocal fold lateralization and/or arytenoidopexy help to improve respiratory function in this setting. These techniques require open approach or specific instruments. The authors describe an original vocal fold lateralization technique performed exclusively via an endoscopic approach. This technique helps to enlarge the glottic aperture, while preserving laryngeal architecture, and permanently improves respiratory function in patients with vocal fold paralysis in adduction.

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Programme des cas cliniques de l’ADF

Publication date: Available online 10 November 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s):

https://ift.tt/2JT3kcW

Place des laboratoires de génétique, d’anatomie pathologique et d’immunologie dans la prise en charge des maladies rares dermatologiques

Publication date: Available online 9 November 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): D. Vidaud, C. Silve, S. Leclerc-Mercier, S. Hüe, S. Ingen-Housz-Oro, C. Bodemer

https://ift.tt/2AWgJ0W

Giant nonfunctioning adrenal tumors: two case reports and review of the literature

There are an estimated 1–2 cases per million per year of adrenocortical carcinoma in the USA. It represents a rare and aggressive malignancy; it is the second most aggressive endocrine malignant disease after ...

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Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology

Sandelius, Å; Portelius, E; Källén, Å; Zetterberg, H; Rot, U; Olsson, B; Toledo, JB; ... Blennow, K; + view all Sandelius, Å; Portelius, E; Källén, Å; Zetterberg, H; Rot, U; Olsson, B; Toledo, JB; Shaw, LM; Lee, VMY; Irwin, DJ; Grossman, M; Weintraub, D; Chen-Plotkin, A; Wolk, DA; McCluskey, L; Elman, L; Kostanjevecki, V; Vandijck, M; McBride, J; Trojanowski, JQ; Blennow, K; - view fewer (2018) Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology. Alzheimer's and Dementia 10.1016/j.jalz.2018.08.006 . (In press). Green open access

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Vitamin D supplementation and neurofilament light chain in multiple sclerosis

Holmøy, T; Røsjø, E; Zetterberg, H; Blennow, K; Lindstrøm, JC; Steffensen, LH; Kampman, MT; (2018) Vitamin D supplementation and neurofilament light chain in multiple sclerosis. Acta Neurologica Scandinavica 10.1111/ane.13037 . (In press).

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Measurement of the suppression and azimuthal anisotropy of muons from heavy-flavor decays in Pb plus Pb collisions at root s(NN)=2.76 TeV with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; ... Zwalinski, L; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adiguzel, A; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Akesson, TPA; Akilli, E; Akimov, A; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, M; Gonzalez, BA; Alvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Anelli, CR; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, A; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; Araujo Ferraz, V; Araujo Pereira, R; Arce, ATH; Ardell, RE; Arduh, FA; Arguin, J-F; Argyropoulos, S; Armbruster, AJ; Armitage, LJ; Armstrong, A; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asimakopoulou, EM; Asquith, L; Assamagan, K; Astalos, R; Atkin, RJ; Atkinson, M; Atlay, NB; Augsten, K; Avolio, G; Avramidou, R; Axen, B; Ayoub, MK; Azuelos, G; Baas, AE; Baca, MJ; Bachacou, H; Bachas, K; Backes, M; Bagnaia, P; Bahmani, M; Bahrasemani, H; Bailey, AJ; Baines, JT; Bajic, M; Bakalis, C; Baker, OK; Bakker, PJ; Gupta, DB; Baldin, EM; Balek, P; Balli, F; Balunas, WK; Banas, E; Bandyopadhyay, A; Banerjee, S; Bannoura, AAE; Barak, L; Barbe, WM; Barberio, EL; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barkeloo, J; Barklow, T; Barlow, N; Barnea, R; Barnes, SL; Barnett, BM; Barnett, RM; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, AJ; Barranco Navarro, L; Barreiro, F; da Costa, JBG; Bartoldus, R; Barton, AE; Bartos, P; Basalaev, A; Bassalat, A; Bates, RL; Batista, SJ; Batlamous, S; Batley, JR; Battaglia, M; Bauce, M; Bauer, F; Bauer, KT; Bawa, HS; Beacham, JB; Beattie, MD; Beau, T; Beauchemin, PH; Bechtle, P; Beck, HC; Beck, HP; Becker, K; Becker, M; Becot, C; Beddall, A; Beddall, AJ; Bednyakov, VA; Bedognetti, M; Bee, CP; Beermann, TA; Begalli, M; Begel, M; Behera, A; Behr, JK; Bell, AS; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Belyaev, NL; Benary, O; Benchekroun, D; Bender, M; Benekos, N; Benhammou, Y; Noccioli, EB; Benitez, J; Benjamin, DP; Benoit, M; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Bergsten, LJ; Beringer, J; Berlendis, S; Bernard, NR; Bernardi, G; Bernius, C; Bernlochner, FU; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertram, IA; Besjes, GJ; Bylund, OB; Bessner, M; Besson, N; Bethani, A; Bethke, S; Betti, A; Bevan, AJ; Beyer, J; Bianchi, RM; Biebel, O; Biedermann, D; Bielski, R; Bierwagen, K; Biesuz, N; Biglietti, M; Billoud, TR; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Biswal, JP; Bittrich, C; Bjergaard, DM; Black, JE; Black, KM; Blair, RE; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blumenschein, U; Blunier, D; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, AS; Bolz, AE; Bomben, M; Bona, M; Bonilla, JS; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Boscherini, D; Bosman, M; Bossio Sola, JD; Bouaouda, K; Boudreau, J; Bouhova-Thacker, E; Boumediene, D; Bourdarios, C; Boutle, SK; Boveia, A; Boyd, J; Boyko, IR; Bozson, AJ; Bracinik, J; Brahimi, N; Brandt, A; Brandt, G; Brandt, O; Braren, F; Bratzler, U; Brau, B; Brau, JE; Madden, WDB; Brendlinger, K; Brennan, AJ; Brenner, L; Brenner, R; Bressler, S; Brickwedde, B; Briglin, DL; Britton, D; Britzger, D; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, WK; Brost, E; Broughton, JH; de Renstrom, PAB; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Bruno, S; Brunt, BH; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Buehrer, F; Bugge, MK; Bulekov, O; Bullock, D; Burch, TJ; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, JTP; Buescher, D; Buescher, V; Buschmann, E; Bussey, P; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, AR; Cabras, G; Cabrera Urban, S; Caforio, D; Cai, H; Cairo, VMM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; Calvente Lopez, S; Calvet, D; Calvet, S; Calvet, TP; Calvetti, M; Toro, RC; Camarda, S; Camarri, P; Cameron, D; Armadans, RC; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; Bret, MC; Cantero, J; Cao, T; Cao, Y; Garrido, MDMC; Caprini, I; Caprini, M; Capua, M; Carbone, RM; Cardarelli, R; Cardillo, FC; Carli, I; Carli, T; Carlino, G; Carlson, BT; Carminati, L; Carney, RMD; Caron, S; Carquin, E; Carra, S; Carrillo-Montoya, GD; Casadei, D; Casado, MP; Casha, AF; Casolino, M; Casper, DW; Castelijn, R; Castillo, FL; Castillo Gimenez, V; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Cerda Alberich, L; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chafaq, A; Chakraborty, D; Chan, SK; Chan, WS; Chan, YL; Chang, P; Chapman, JD; Charlton, DG; Chau, CC; Barajas, CAC; Che, S; Chegwidden, A; Chekanov, S; Chekulaev, S; Chelkov, GA; Chelstowska, MA; Chen, C; Chen, CH; Chen, H; Chen, J; Chen, S; Chen, SJ; Chen, X; Chen, Y; Chen, Y-H; Cheng, HC; Cheng, HJ; Cheplakov, A; Cheremushkina, E; El Moursli, RC; Cheu, E; Cheung, K; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, I; Chiu, YH; Chizhov, M; Choi, K; Chomont, AR; Chouridou, S; Chow, YS; Christodoulou, V; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; Cinca, D; Cindro, V; Cioara, IA; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Clark, A; Clark, MR; Clark, PJ; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Coimbra, AEC; Colasurdo, L; Cole, B; Colijn, AP; Collot, J; Conde Muino, P; Coniavitis, E; Connell, SH; Connelly, IA; Constantinescu, S; Conventi, F; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Corradi, M; Corrigan, EE; Corriveau, F; Cortes-Gonzalez, A; Costa, MJ; Costanzo, D; Cottin, G; Cowan, G; Cox, BE; Crane, J; Cranmer, K; Crawley, SJ; Creager, RA; Cree, G; Crepe-Renaudin, S; Crescioli, F; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Donszelmann, TC; Cukierman, AR; Curatolo, M; Cuth, J; Czekierda, S; Czodrowski, P; Da Cunha Sargedas De Sousa, MJ; Da Via, C; Dabrowski, W; Dado, T; Dahbi, S; Dai, T; Dallaire, F; Dallapiccola, C; Dam, M; D'amen, G; Dandoy, JR; Daneri, MF; Dang, NP; Dann, ND; Danninger, M; Dao, V; Darbo, G; Darmora, S; Dartsi, O; Dattagupta, A; Daubney, T; D'Auria, S; Davey, W; David, C; Davidek, T; Davis, DR; Dawe, E; Dawson, I; De, K; De Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; De Regie, JBDV; Debenedetti, C; Dedovich, D; Dehghanian, N; Del Gaudio, M; Del Peso, J; Delgove, D; Deliot, F; Delitzsch, CM; Della Pietra, M; Della Volpe, D; Dell'Acqua, A; Dell'Asta, L; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Denisov, SP; Denysiuk, D; D'Eramo, L; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, MR; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, FA; Dias Do Vale, T; Diaz, MA; Dickinson, J; Diehl, EB; Dietrich, J; Cornell, SD; Dimitrievska, A; Dingfelder, J; Dittus, F; Djama, F; Djobava, T; Djuvsland, J; Do Vale, MAB; Dobre, M; Dodsworth, D; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donini, J; D'onofrio, A; D'Onofrio, M; Dopke, J; Doria, A; Dova, MT; Doyle, AT; Drechsler, E; Dreyer, E; Dreyer, T; Dris, M; Du, Y; Duarte-Campderros, J; Dubinin, F; Dubreuil, A; Duchovni, E; Duckeck, G; Ducourthial, A; Ducu, OA; Duda, D; Dudarev, A; Dudder, AC; Duffield, EM; Duflot, L; Duhrssen, M; Duelsen, C; Dumancic, M; Dumitriu, AE; Duncan, AK; Dunford, M; Duperrin, A; Yildiz, HD; Dueren, M; Durglishvili, A; Duschinger, D; Dutta, B; Duvnjak, D; Dyndal, M; Dysch, S; Dziedzic, BS; Eckardt, C; Ecker, KM; Edgar, RC; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; El Kosseifi, R; Ellajosyula, V; Ellert, M; Ellinghaus, F; Elliot, AA; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Ennis, JS; Epland, MB; Erdmann, J; Ereditato, A; Errede, S; Escalier, M; Escobar, C; Esposito, B; Estrada Pastor, O; Etienvre, A; Etzion, E; Evans, H; Ezhilov, A; Ezzi, M; Fabbri, F; Fabbri, L; Fabiani, V; Facini, G; Faisca Rodrigues Pereira, RM; Fakhrutdinov, RM; Falciano, S; Falke, PJ; Falke, S; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, EM; Farooque, T; Farrell, S; Farrington, SM; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Giannelli, MF; Favareto, A; Fawcett, WJ; Fayard, L; Fedin, OL; Fedorko, W; Feickert, M; Feigl, S; Feligioni, L; Feng, C; Feng, EJ; Feng, M; Fenton, MJ; Fenyuk, AB; Feremenga, L; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; de Lima, DEF; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipcic, A; Filthaut, F; Finelli, KD; Fiolhais, MCN; Fiorini, L; Fischer, C; Fisher, WC; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, RRM; Flick, T; Flierl, BM; Flores, LM; Castillo, LRF; 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Measurements of differential cross sections of top quark pair production in association with jets in pp collisions at √s=13 TeV using the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; ... Araque, JP; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Akerstedt, H; Åkesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Anjos, N; Annovi, A; Antel, C; Antonelli, M; Antonov, A; Antrim, DJA; Anulli, F; Aoki, M; Aperio Bella, L; Arabidze, G; Arai, Y; Araque, JP; - view fewer (2018) Measurements of differential cross sections of top quark pair production in association with jets in pp collisions at √s=13 TeV using the ATLAS detector. Journal of High Energy Physics , 2018 (10) , Article 159. 10.1007/JHEP10(2018)159 . Green open access

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Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons

Nazir, FH; Becker, B; Brinkmalm, A; Höglund, K; Sandelius, Å; Bergström, P; Satir, TM; ... Zetterberg, H; + view all Nazir, FH; Becker, B; Brinkmalm, A; Höglund, K; Sandelius, Å; Bergström, P; Satir, TM; Öhrfelt, A; Blennow, K; Agholme, L; Zetterberg, H; - view fewer (2018) Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons. Neurochemistry International , 121 pp. 38-49. 10.1016/j.neuint.2018.10.014 . (In press). Green open access

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Observation of an Unusual Upward-Going Cosmic-Ray-like Event in the Third Flight of ANITA

Gorham, PW; Rotter, B; Allison, P; Banerjee, O; Batten, L; Beatty, JJ; Bechtol, K; ... Wissel, SA; + view all Gorham, PW; Rotter, B; Allison, P; Banerjee, O; Batten, L; Beatty, JJ; Bechtol, K; Belov, K; Besson, DZ; Binns, WR; Bugaev, V; Cao, P; Chen, CC; Chen, CH; Chen, P; Clem, JM; Connolly, A; Cremonesi, L; Dailey, B; Deaconu, C; Dowkontt, PF; Fox, BD; Gordon, JWH; Hast, C; Hill, B; Hughes, K; Huang, JJ; Hupe, R; Israel, MH; Javaid, A; Lam, J; Liewer, KM; Lin, SY; Liu, TC; Ludwig, A; Macchiarulo, L; Matsuno, S; Miki, C; Mulrey, K; Nam, J; Naudet, CJ; Nichol, RJ; Novikov, A; Oberla, E; Olmedo, M; Prechelt, R; Prohira, S; Rauch, BF; Roberts, JM; Romero-Wolf, A; Russell, JW; Saltzberg, D; Seckel, D; Schoorlemmer, H; Shiao, J; Stafford, S; Stockham, J; Stockham, M; Strutt, B; Varner, GS; Vieregg, AG; Wang, SH; Wissel, SA; - view fewer (2018) Observation of an Unusual Upward-Going Cosmic-Ray-like Event in the Third Flight of ANITA. Physical Review Letters , 121 (16) , Article 161102. 10.1103/PhysRevLett.121.161102 . Green open access

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Blood-based biomarkers for Alzheimer's disease - an update

Zetterberg, H; (2018) Blood-based biomarkers for Alzheimer's disease - an update. Journal of Neuroscience Methods 10.1016/j.jneumeth.2018.10.025 . (In press).

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Search for resonant W Z production in the fully leptonic final state in proton–proton collisions at √s = 13 TeV with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; ... Arai, Y; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adiguzel, A; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Åkesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Aperio Bella, L; Arabidze, G; Arai, Y; - view fewer (2018) Search for resonant W Z production in the fully leptonic final state in proton–proton collisions at √s = 13 TeV with the ATLAS detector. Physics Letters, Section B , 787 pp. 68-88. 10.1016/j.physletb.2018.10.021 . Green open access

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Object Classification Using Hybrid Fiber Optical Force/Proximity Sensor

Konstantinova, J; Cotugno, G; Stilli, A; Noh, Y; Althoefer, K; (2017) Object Classification Using Hybrid Fiber Optical Force/Proximity Sensor. In: Proceedings of 16th IEEE Sensors 2017. (pp. pp. 543-545). IEEE: Glasgow, UK. Green open access

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CrossTalk proposal: a central hypoxia sensor contributes to the excitatory hypoxic ventilatory response

Funk, GD; Gourine, AV; (2018) CrossTalk proposal: a central hypoxia sensor contributes to the excitatory hypoxic ventilatory response. Journal of Physiology , 596 (15) pp. 2935-2938. 10.1113/JP275707 .

https://ift.tt/2FgWiA9

Extending the SACOC algorithm through the Nystrom method for dense manifold data analysis

Menéndez, HD; Otero, FEB; Camacho, D; (2017) Extending the SACOC algorithm through the Nystrom method for dense manifold data analysis. International Journal of Bio-Inspired Computation , 10 (2) pp. 127-135. 10.1504/IJBIC.2017.085894 . Green open access

https://ift.tt/2qFOhdM

Multi-organ quantitative MRI for the assessment of liver disease - A whole much more than the sum of its parts

Chouhan, MD; Taylor, SA; Mookerjee, RP; (2018) Multi-organ quantitative MRI for the assessment of liver disease - A whole much more than the sum of its parts. Journal of Hepatology , 69 (5) pp. 996-998. 10.1016/j.jhep.2018.05.037 . Green open access

https://ift.tt/2Fe5IMt

Properties of the signal mode in the polariton optical parametric oscillator regime

Dunnett, K; Ferrier, A; Zamora, A; Dagvadorj, G; Szymanska, MH; (2018) Properties of the signal mode in the polariton optical parametric oscillator regime. Physical Review B , 98 (16) 10.1103/PhysRevB.98.165307 . Green open access

https://ift.tt/2qBwPag

The Zurich Corpus of Vowel and Voice Quality, Version 1.0

Maurer, D; D'Heureuse, C; Suter, H; Dellwo, V; Friedrichs, D; Kathiresan, T; (2018) The Zurich Corpus of Vowel and Voice Quality, Version 1.0. In: Yegnanarayana, B, (ed.) Proceedings of INTERSPEECH 2018. (pp. pp. 1417-1421). International Speech Communication Association (ISCA) Green open access

https://ift.tt/2FgWjnH

Cardiomyopathies in children: Mitochondrial and storage disease

Norrish, G; Elliott, PM; (2018) Cardiomyopathies in children: Mitochondrial and storage disease. Progress in Pediatric Cardiology 10.1016/j.ppedcard.2018.08.009 . (In press).

https://ift.tt/2qC4AYS

Evolution of Electrochemical Cell Designs for In-Situ and Operando 3D Characterization

Tan, C; Daemi, SR; Taiwo, OO; Heenan, TMM; Brett, DJL; Shearing, PR; (2018) Evolution of Electrochemical Cell Designs for In-Situ and Operando 3D Characterization. Materials , 11 (11) , Article 2157. 10.3390/ma11112157 . Green open access

https://ift.tt/2Feqage

Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region

Liu, L; Yu, H; Du, K; Wang, Z; Gan, Y; Huang, H; (2018) Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region. Microbial Cell Factories , 17 (1) , Article 165. 10.1186/s12934-018-1012-x . Green open access

https://ift.tt/2qMawip

Autonomous Object Handover Using Wrist Tactile Information

Konstantinova, J; Krivic, S; Stilli, A; Piater, JH; Althoefer, K; (2017) Autonomous Object Handover Using Wrist Tactile Information. In: Gao, Y and Fallah, S and Jin, Y and Lekakou, C, (eds.) Proceedings of the Towards Autonomous Robotic Systems. TAROS 2017. Lecture Notes in Computer Science, vol 10454. (pp. pp. 450-463). Springer: Cham. Green open access

https://ift.tt/2Feq7B4

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

Adams, C; Richmond, RC; Santos Ferreira, DL; Spiller, W; Tan, VY; Zheng, J; Wurtz, P; ... Martin, RM; + view all Adams, C; Richmond, RC; Santos Ferreira, DL; Spiller, W; Tan, VY; Zheng, J; Wurtz, P; Donovan, JL; Hamdy, FC; Neal, DE; Lane, JA; Davey Smith, G; Relton, CL; Eeles, RA; Henderson, BE; Haiman, CA; Kote-Jarai, Z; Schumacher, FR; Amin Al Olama, A; Benlloch, S; Muir, K; Berndt, SI; Conti, DV; Wiklund, F; Chanock, SJ; Gapstur, SM; Stevens, VL; Tangen, CM; Batra, J; Clements, JA; Grönberg, H; Pashayan, N; Schleutker, J; Albanes, D; Wolk, A; West, CML; Mucci, LA; Cancel-Tassin, G; Koutros, S; Sørensen, KD; Maehle, L; Travis, RC; Hamilton, R; Ingles, SA; Rosenstein, BS; Lu, Y-J; Giles, GG; Kibel, AS; Vega, A; Kogevinas, M; Penney, KL; Park, JY; Stanford, JL; Cybulski, C; Nordestgaard, BG; Brenner, H; Maier, C; Kim, J; John, EM; Teixeira, MR; Neuhausen, SL; DeRuyck, K; Razack, A; Newcomb, LF; Lessel, D; Kaneva, RP; Usmani, N; Claessens, F; Townsend, P; Gago Dominguez, M; Roobol, MJ; Menegaux, F; Khaw, K-T; Cannon-Albright, LA; Pandha, H; Thibodeau, SN; Martin, RM; - view fewer (2018) Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study. Cancer Epidemiology, Biomarkers and Prevention 10.1158/1055-9965.EPI-18-0079 . (In press).

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Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand

Jovanovic, KK; Tanic, M; Ivanovic, I; Gligorijevic, N; Dojcinovic, BP; Radulovic, S; (2016) Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand. Journal of Inorganic Biochemistry , 163 pp. 362-373. 10.1016/j.jinorgbio.2016.04.011 . Green open access

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Ethnic and Age Disparities in Outcomes among Liver Transplant Waitlist Candidates

Background Despite the increasing prevalence of end-stage liver disease in older adults, there is no consensus to determine suitability for liver transplantation (LT) in the elderly. Disparities in LT access exist, with a disproportionately lower percentage of African Americans (AAs) receiving LT. Understanding waitlist outcomes in older adults, specifically AAs, will identify opportunities to improve LT access for this vulnerable population. Methods All adult, liver-only white and AA LT waitlist candidates (1/1/2003-10/1/2015) were identified in the Scientific Registry of Transplant Recipients. Age and race categories were defined: younger (age

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First Report of siRNA Uptake During Ex Vivo Hypothermic and Normothermic Liver Machine Perfusion

No abstract available

https://ift.tt/2OzrvxG

Patient selection and ethical considerations - justifying combined lung AND liver transplantation

No abstract available

https://ift.tt/2z0dHYg

Pretransplant cancer in kidney recipients in relation to recurrent and de novo cancer incidence posttransplantation and implications for graft and patient survival

Background Whether kidney transplant recipients who were treated for a malignant tumor prior to transplantation are at an increased risk of developing a tumor post transplantation has not been adequately quantified and characterized. Methods We studied more than 270 000 patients on whom pre and posttransplant malignancy data were reported to the Collaborative Transplant Study. More than 4000 of these patients were treated for pretransplant malignancy. The posttransplant tumor incidence in these patients was compared to that in recipients without a pretransplant tumor. Cox regression considering multiple confounders was applied. Results Significant increases in posttransplant tumor incidence with HR ranging from 2.10 to 5.47 (all P

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Steatosis in Liver Transplantation: Current Limitations and Future Strategies

In parallel with the pandemic of obesity and diabetes, the prevalence of nonalcoholic fatty liver disease (NAFLD) has progressively increased. Non-alcoholic steatohepatitis (NASH), a subtype of NAFLD has also augmented considerably being currently cirrhosis due to NASH the second indication for liver transplantation in USA. Innovative treatments for NASH have shown promising results in phase-2 studies and are being presently evaluated in phase-3 trials. On the other hand, the high mortality on the liver transplant wait list and the organ shortage has obligated the transplant centres to consider suboptimal grafts, such as steatotic livers for transplantation. Fatty livers are vulnerable to preservation injury resulting in a higher rate of primary non-function, early allograft dysfunction and post-transplant vascular and biliary complications. Macrosteatosis of more than 30% in fact is an independent risk factor for graft loss. Therefore, it needs to be considered into the risk assessment scores. Growing evidence supports that moderate and severe macrosteatotic grafts can be successfully used for liver transplantation with careful recipient selection. Protective strategies, such as machine-based perfusion have been developed in experimental setting to minimize preservation related injury and are now on the verge to move into the clinical implementation. This review focuses on the current and potential future treatment of NASH and the clinical practice in fatty liver transplantation, highlights its limitations and optimal allocation, and summarizes the advances of experimental protective strategies, and their potential for clinical application to increase the acceptance and improve the outcomes after liver transplantation with high-grade steatotic livers. Authors contributed equally to this paper, Ivan Linares MD, Matyas Hamar MD. Correspondence author: Markus Selzner, MD, Associate Professor of Surgery, University of Toronto, General Surgery & Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, 585 University Avenue, 11 PMB 178, Toronto, ON M5G 2N2, Phone: 416-340-4800 ext. 5884 Fax: 416-340-5321, e-mail: markus.selzner@uhn.ca Authorship: -Ivan Linares participated in performance of research, research design and writing the paper (lin85ij@outlook.com) -Matyas Hamar participated in performance of research, research design and writing the paper (mahamar@gmail.com) -Nazia Selzner participated in research design and writing the paper (Nazia.Selzner@uhn.ca) -Markus Selzner participated in research design and writing the paper (Markus.Selzner@uhn.ca) Disclosure: The authors of this manuscript have no conflicts of interest to disclose as described by the Transplantation Journal. Funding: None Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Impact of Donor Hepatectomy Time during Organ Procurement in Donation after Circulatory Death Liver Transplantation: The United Kingdom Experience

Background No data exists to evaluate how hepatectomy time (HT), in the context of donation after cardiac death (DCD) procurement, impacts on short and long-term outcomes following liver transplantation (LT). In this study we analyse the impact of the time from aortic perfusion to end of hepatectomy on outcomes following DCD LT in the UK. Methods An analysis of 1112 DCD donor LT across all UK transplant centres between 2001 and 2015 was performed, using data from the UK Transplant Registry. Donors were all Maastricht Category III. Graft survival after transplantation was estimated using Kaplan-Meier method and logistic regression to identify risk factors for PNF and short and long-term graft survival after LT. Results Incidence of PNF was 4% (40) and in multivariate analysis only CIT >8 hrs. (HR 2.186 (1.113-4.294, p=0.023) and HT > 60 mins (HR 3.669 (1.363-9.873, p=0.01) were correlated with PNF. Overall 90-day, 1 year, 3 year and 5 year graft survival in DCD LT was 91.2%, 86.5%, 80.9% and 77.7% (compared to a DBD cohort in the same period (n=7221) 94%, 91%, 86.6%, and 82.6% respectively (p 60mins, donor age >45 yrs., CIT> 8 hours and recipient previous abdominal surgery. Conclusions There is a negative impact of prolonged HT on outcomes on DCD LT and although HT > 60 mins is not a contraindication for utilisation it should be part of a multifactorial assessment with established prognostic donor factors such as age (>45yrs) and CIT (>8hrs) for an appropriately selected recipient. No conflicts of interest Correspondence: Mr. Shahid Farid, Consultant Transplant Surgeon, Department of Transplantation, St James University Hospital, Beckett Street, Leeds, United Kingdom, LS9 7TF. s.farid@nhs.net Authorship Page: SG Farid: Participated in research design, performance of the research, statistical analysis, writing and final review of the paper. MS Attia: Participated in research design and final review of the paper. D Vijayanand: Participated in research design, writing and final review of the paper. V Upasani: Participated in research design, performance of the research, statistical analysis, writing and final review of the paper. S Willis: Participated in research design, performance of the research, statistical analysis, writing and final review of the paper. A Barlow: Participated in the writing and final review of the paper. E Hidalgo: Participated in research design, performance of the research, writing and final review of the paper. N Ahmad: Participated in research design, performance of the research, statistical analysis, writing and final review of the paper. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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