Medicine by Sfakianakis Alexandros: 08/25/18

Σάββατο 25 Αυγούστου 2018

Testimony of an Ethiopian girl sexually assaulted by her stepfather: a case report

The sensitiveness and stigma associated with sexual assault deter many victims from speaking about their experiences. This silence of victims worsens the problem, especially in patriarchal communities like Eth...

https://ift.tt/2BTZlMC

Treatment of Genital Psoriasis: A Systematic Review

Abstract

Genital psoriasis affects approximately 63% of psoriasis patients at least once in their lifetime. More than any other area on the body, genital lesions significantly impair patients' psychologic well-being and quality of life. We aimed to systematically review the published evidence on the safety, efficacy, and tolerability of treatments of genital psoriasis and synthesize the available clinical data. A total of 1 randomized controlled trial, 11 open-label studies, and 26 case reports were included in our analysis, representing a total of 458 patients, of which 332 were adults and 126 were children. Topical corticosteroids were commonly used first-line for genital psoriasis and were well tolerated. Nonsteroidal agents, such as topical calcineurin inhibitors or vitamin D analogs, were also efficacious, but were often irritating. One systemic agent, ixekizumab, demonstrated efficacy in reducing genital psoriasis symptoms in a large, randomized, placebo-controlled trial. Various systemic and topical medications may improve genital psoriasis lesions, but there is a lack of high-quality evidence to guide clinical decision-making. Specific reporting of efficacy for genital psoriasis in larger controlled studies of psoriasis treatments are necessary to improve the available evidence regarding the optimal treatment regimen for genital psoriasis.

https://ift.tt/2oanBAu

New Animal Model of Extrinsic Dental Erosion—Erosive Effect on the Mouse Molar Teeth

Publication date: Available online 24 August 2018

Source: Archives of Oral Biology

Author(s): Amela Tulek, Muhammad Saeed, Aida Mulic, Kjersti Refsholt Stenhagen, Tor Paaske Utheim, Hilde Kanli Galtung, Cuong Khuu, Minou Nirvani, Marthe Smedmoen Kristiansen, Amer Sehic

Abstract

Objective

Consumption of acidic food and drinks is considered as important risk factor for development of dental erosion. There are severalin vitro and in situ studies focusing on the risk indicators and preventive treatment, however, the need for a standardized animal model has been emphasised for many years. The aim was to establish an animal model of extrinsic dental erosion, which may serve as a standard for future studies to improve our understanding of the erosion.

Design

Two acidic drinks, sports drink and cola drink, were given to young mice for six weeks. Experimental and control (water) molars and incisors were dissected out and observed by scanning electron microscopy (SEM). Mandibular first molars were subsequently ground transversely and observed again by SEM. The tooth height and enamel thickness were measured on the SEM images.

Results

The lingual surface of the mandibular molars was most eroded after consumption of acidic drinks. The cola drink exhibited higher erosive effect on mandibular molars compared to sports drink. The lingual tooth height, compared to control, was about 34% and 18% lower in the cola drink and sports drink molars, respectively. Compared to the control molars, the lingual enamel was about 23% thinner in the sports drink molars and totally eroded on the certain lingual areas of the cola drink molars.

Conclusions

This new animal model of extrinsic dental erosion and the presented method with ground molars observed in SEM are suitable for further studies, which will gain deeper insights into the erosive disease.

https://ift.tt/2o9LfgJ

Platycarya strobilacea leaf extract inhibits tumor necrosis factor-α production and bone loss induced by Porphyromonas gingivalis-derived lipopolysaccharide

Publication date: Available online 24 August 2018

Source: Archives of Oral Biology

Author(s): Joo-Hee Lee, Hyungkeun Kim, Jae Hoon Shim, Junhee Park, Sun Kyoung Lee, Kwang-Kyun Park, Won-Yoon Chung

Abstract

Objective

Remodeling of alveolar bone is controlled by osteoclast-mediated bone resorption and osteoblast-induced bone formation. LPS of Porphyromonas gingivalis, a major causative agent of periodontitis, produces proinflammatory cytokines in host immune cells, which thereby triggers osteoclastogenesis and leads to alveolar bone resorption. We investigated the anti-periodontitis potential of Platycarya strobilacea leaf extract (PLE), which is used as a traditional medicine in Asian countries.

Design

TNF-α levels in cell culture media were measured using a commercially available enzyme-linked immunosorbent assay kit. Osteoclast differentiation was observed by tartrate-resistant acid phosphatase staining, and the expression levels of osteoclastogenic genes were measured by quantitative real-time PCR. Bone-resorbing activity was confirmed by the resorption pit formation, gelatin zymographic, and the cathepsin K activity assays. Osteogenic differentiation was confirmed with an ALP activity assay and alizarin red S staining.

Results

PLE treatment inhibited the production of TNF-α inP. gingivalis LPS-stimulated RAW264.7 macrophages. In bone marrow-derived macrophages serving as osteoclast precursors, PLE treatment blocked RANKL-induced osteoclastogenesis and gene expression levels of the osteoclastogenic transcription factor NFATc1, DC-STAMP for osteoclast fusion, and cathepsin K for osteoclast activity. In addition, PLE treatment reduced the formation of resorption pits and the secretion of MMP 9 and cathepsin K from the differentiated osteoclasts. Furthermore, PLE treatment induced osteogenesis by increasing ALP activity and calcium content in preosteoblastic cells.

Conclusion

PLE inhibitsP. gingivalis LPS-induced TNF-α production and bone resorption and induces bone formation. PLE may be a beneficial agent to promote oral health by inhibiting periodontitis-induced alveolar bone loss.

https://ift.tt/2BLPrg7

Non-syndromic tooth agenesis patterns and their association with other dental anomalies: A retrospective study

Publication date: Available online 24 August 2018

Source: Archives of Oral Biology

Author(s): Bianca Núbia Souza-Silva, Walbert de Andrade Vieira, Ítalo de Macedo Bernardino, Marília Jesus Batista, Marcos Alan Vieira Bittencourt, Luiz Renato Paranhos

Abstract

Objective

This study aimed to investigate the prevalence and the factors associated with non-syndromic tooth agenesis, besides identifying its pattern of occurrence.

Study Design

Pre-orthodontic exams of 3400 subjects, aged 8 to 30 years, were selected from a radiographic center in Brazil. Panoramic and periapical radiographs were analyzed to verify the presence of tooth agenesis and other six dental anomalies. Descriptive statistics were calculated using the Tooth Agenesis Code tool and, to evaluate significant associations, a negative binomial regression model was constructed. Besides, unadjusted and adjusted prevalence ratios (PR) were calculated for the bivariate and the multivariate analysis.

Results

Prevalence of tooth agenesis was 3.0% (n = 68) and 41 different phenotypic patterns were observed. Teeth most often symmetrically missing were maxillary lateral incisors (13.2%) and mandibular second premolars (8.8%). Females (PR = 3.49, CI 95% = 1.96-6.19) presented more tooth agenesis. Other dental anomalies, such as palatal displacement of maxillary canine and infraocclusion of primary molar were significantly more frequent (p < 0.001) in subjects with agenesis.

Conclusion

There was a strong relationship between tooth agenesis and gender and the association with other dental anomalies was significant, with the exception of the supernumerary teeth, which seems to be independent.

https://ift.tt/2o9L4SB

UK Immunotherapy Study: Reanalysis by a combined symptom and medication score

Publication date: Available online 24 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Anthony J. Frew, Christian Ljørring, Hendrik Wolf, Eike Wüstenberg, Stephen R. Durham, Christopher J. Corrigan, Richard J. Powell, Oliver Pfaar

https://ift.tt/2woA8nQ

Topical platelet rich plasma versus hyaluronic acid during fat graft myringoplasty

Publication date: Available online 24 August 2018

Source: American Journal of Otolaryngology

Author(s): Yasser Ahmed Fouad, Mohammad Abdelhady, Mohammad El-anwar, Ezzat Merwad

Abstract

Objectives

To evaluate the effect of adding platelet rich plasma (PRP) or Hyaluronic acid (HA) to fat graft myringoplasty (FGM) for medium sized central tympanic membrane (TM) perforations.

Methods

This is a retrospective study conducted on 69 patients with medium sized central TM perforations. In 21 patients, PRP was used with the FGM; and in 23 patients, HA was used with the FGM; while in 25 patients, pure FGM was performed without adding an enhancing material.

Results

Successful TM perforation repair was achieved in 18 ears (85.7) with using PRP with FGM and in 20 ears (87%) with using HA with FGM and in 15 ears (60%) with pure FGM.

Conclusion

FGM with adding PRP or HA is more successful in closure of TM perforation than pure FGM in case of medium sized central TM perforation.

https://ift.tt/2BIk5qG

IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis

Publication date: Available online 24 August 2018

Source: Clinical Immunology

Author(s): Xin Zhang, Nazanin Kiapour, Sahil Kapoor, Joseph R. Merrill, Yongjuan Xia, Woomi Ban, Stephanie M. Cohen, Bentley R. Midkiff, Valerie Jewells, Yen-Yu I. Shih, Silva Markovic-Plese

Abstract

IL-11 induced differentiation and expansion of Th17 cells in patients with early relapsing-remitting multiple sclerosis (RRMS). In mice with relapsing-remitting experimental autoimmune encephalomyelitis (RREAE), IL-11 exacerbated disease, induced demyelination in the central nervous system (CNS), increased the percentage of IL-17A⁺CD4⁺ Th17 cells in the CNS in the early acute phase, and up-regulated serum IL-17A levels and the percentage of IL-17A⁺CD4⁺ Th17 cells in lymph nodes, and IFN-γ⁺CD4⁺ T cells in spinal cord in the RR phase. IL-11 antagonist suppressed RREAE disease activities, inhibited IL-17A⁺CD4⁺ cell infiltration and demyelination in the CNS, and decreased the percentage of IL-17A⁺CD4⁺ T cells in peripheral blood mononuclear cells and ICAM1⁺CD4⁺ T cells in brain and SC. Diffusion Tensor Imaging indicated that IL-11 antagonist inhibited demyelination in several brain regions. We conclude that by suppressing Th17 cell-mediated neuroinflammation and demyelination, IL-11 antagonist can be further studied as a potential selective and early therapy for RRMS.

https://ift.tt/2NhsLWx

Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90

Publication date: Available online 24 August 2018

Source: Clinical Immunology

Author(s): Maurer Kelly, Shi Lihua, Zhang Zhe, Song Li, Paucar Yoselin, Petri Michelle, E. Sullivan Kathleen

Abstract

Systemic lupus erythematosus (SLE) represents an autoimmune disease in which activation of the type I interferon pathway leads to dysregulation of tolerance and the generation of autoantibodies directed against nuclear constituents. The mechanisms driving the activation of the interferon pathway in SLE have been the subject of intense investigation but are still incompletely understood. Transposable elements represent an enormous source of RNA that could potentially stimulate the cell intrinsic RNA-recognition pathway, leading to upregulation of interferons. We used RNA-seq to define transposable element families and subfamilies in three cell types in SLE and found diverse effects on transposable element expression in the three cell types and even within a given family of transposable elements. When potential mechanisms were examined, we found that Hsp90 inhibition could drive increased expression of multiple type of transposable elements. Both direct inhibition and the delivery of a heat shock itself, which redirects heat shock regulators (including Hsp90) off of basal expression promoters and onto heat shock-responsive promoters, led to increased transposable element expression. This effect was amplified by the concurrent delivery of a histone deacetylase inhibitor. We conclude that transposable elements are dysregulated in SLE and there are tissue-specific effects and locus-specific effects. The magnitude of RNAs attributable to transposable elements makes their dysregulation of critical interest in SLE where transposable element RNA complexed with proteins has been shown to drive interferon expression.

https://ift.tt/2PCmeXR

Association of Preferences for Papillary Thyroid Cancer Treatment With Disease Terminology: A Discrete Choice Experiment.

Association of Preferences for Papillary Thyroid Cancer Treatment With Disease Terminology: A Discrete Choice Experiment.

JAMA Otolaryngol Head Neck Surg. 2018 Aug 22;:

Authors: Nickel B, Howard K, Brito JP, Barratt A, Moynihan R, McCaffery K

Abstract
Importance: Given recent evidence of overdiagnosis and overtreatment of small papillary thyroid cancers (PTCs) and other low-risk cancers, strategies are needed to help patients consider less invasive treatment options.
Objectives: To determine which factors influence treatment preferences for patients with PTC, and the trade-offs in treatment factors people are willing to accept, and to understand how terminology influences preferences and benefit-harm trade-offs.
Design, Setting, and Participants: Preferences in PTC treatment were evaluated using a discrete choice experiment (DCE) conducted as a web-based survey using an existing public online research panel. Participants were randomized to receive 1 of 2 frames of information based on the terminology used to describe the condition: "cancer" or "lesion." Participants chose between 3 treatment options for PTC (thyroidectomy, hemithyroidectomy, and active surveillance). Analyses were conducted using a mixed logit model.
Main Outcomes and Measures: The main outcome variable was treatment preference; attributes of treatment options and sociodemographic characteristics were explanatory variables.
Results: The DCE was completed by 2054 participants (993 [48.3%] men and 1061 [51.7%] women; mean [SD] age, 46.0 [16.5] years) with no history of thyroid cancer. Participants preferred options with less frequent follow-up, lower out-of-pocket costs, lower chances of having voice and calcium level problems, and a lower risk of developing invasive thyroid cancer and of dying of thyroid cancer. When trading benefits against harms, participants were willing to accept a higher number of extra patients experiencing adverse effects to avoid a thyroid cancer death when the condition was described as a cancer compared with a lesion. Specifically, participants for whom the condition was described as a cancer were willing to accept more patients requiring lifelong medication (mean, 273; 95% CI, 207-339 vs mean, 98; 95% CI, 66-131), experiencing calcium problems (mean, 110; 95% CI, 77-144 vs mean, 56; 95% CI, 55-58), and fatigue (mean, 958; 95% CI, 691-1224 vs mean, 469; 95% CI, 375-564). For both the cancer and lesion terminology, health literacy consistently was associated with preferences for treatment options. Those with lower health literacy had a significantly lower preference for less invasive treatment options.
Conclusions and Relevance: This study makes an important contribution to understanding how attributes of treatment options, terminology, and patient characteristics, in particular health literacy, influence treatment decision making for PTC. As a result of increasing evidence of the indolent nature of PTC and other low-risk cancers, strategies to deal with potential overtreatment are critically needed.
Trial Registration: Australian New Zealand Clinical Trials Registry: ACTRN12617000066381.

PMID: 30140909 [PubMed - as supplied by publisher]

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Association of the Word Cancer With Thyroid Cancer Treatment Decisions-A Rose by Any Other Name.

Association of the Word Cancer With Thyroid Cancer Treatment Decisions-A Rose by Any Other Name.

JAMA Otolaryngol Head Neck Surg. 2018 Aug 22;:

Authors: Haymart MR

PMID: 30140895 [PubMed - as supplied by publisher]

https://ift.tt/2MQHZ7F

Circulating tumor cells and cell-free nucleic acids in patients with gynecological malignancies

Abstract

The ability to detect cancer cells in the blood or in the bone marrow offers invaluable information which potentially impacts early diagnosis, monitoring of treatment, and prognosis. Accessing blood or other body fluids has the additional advantage of being less invasive than biopsy. Consequently, considerable effort has been invested in the last 20 years in optimizing assays which may identify malignant cells at these anatomic sites. Detection of nucleic acids has been applied as alternative approach in this context, first targeting single cancer-associated genes using PCR-based technology, and recently using assays which identify different DNA classes, as well as microRNAs and exosomes. The present review focuses on studies which applied these assays to the detection of cells or cellular components originating from gynecological cancers.

https://ift.tt/2wmUNIR

Telemedicine: a Primer

Abstract

Purpose of Review

Due to rapid advancements in quality of real-time, interactive, audio-visual, and digital technologies as well as impressive gains in internet speed and capacity, medicine delivered over distance is happening faster than many healthcare providers and leaders can grasp.

Recent Findings

Depending on which market report you ascribe to, industry projections for the global compounded annual growth rate of telemedicine are between 13 and 27%, with valuation growing to over 20 billion US dollars in the next several years. The Mayo Clinic has reworked its entire telemedicine interest to a model with centralized operations, one virtual technology platform, standardized training, and connectedness for all of its locations. The National Quality Forum spent 2016 and 2017 formulating 70 some pages of recommendations for expanded measures to valuate telemedicine over the foreseeable future. There are so many patient experience studies indicating high satisfaction with telemedicine, that professionals in the industry accept it as fact. Telemedicine is leaving novel to the past.

Summary

This short, informative piece of writing includes expert opinion and research findings about what is telemedicine, why one should practice telemedicine, and how one should approach implementation; a primer from which to grow.

https://ift.tt/2wc6dQi

A Review of Portable Electronic Spirometers: Implications for Asthma Self-Management

Abstract

Purpose of Review

Although portable electronic spirometers allow for at-home lung function monitoring, a comprehensive review of these devices has not yet been conducted. We conducted a systematic search and review of commercially available portable electronic spirometers designed for asthma patient use.

Recent Findings

All devices (N = 16) allowed for monitoring of basic lung function parameters, but only 31% provided in-app videos on how to perform breathing maneuvers. Most devices (63%) provided graphical representations of lung function results, but only 44% gave immediate feedback on the quality of the breathing maneuver. Several devices (25%) were FDA-approved and cost ranged from US$99 to $1390. Information on data security (63%), measurement accuracy (50%), and association with patient outcomes (0%) was commonly limited.

Summary

This review found that providers' ability to make informed decisions about whether asthma patients may benefit from portable electronic spirometers is limited due to lack of patient outcome data.

https://ift.tt/2P4tF9e

The Role of Imaging in the Management of Cystic Formations of the Mobile Spine (CYFMOS)

Abstract

Purpose of Review

The purpose of this review is to give a better understanding of the pathogenesis of cystic formations of the mobile spine (CYFMOS) and the correlating imaging findings. This would help with medical decision-making, given the plethora of conservative, interventional, and surgical treatment options.

Recent Findings

There has been a general understanding that CYFMOS are associated with degenerative spine changes. More recent articles however have suggested that identifying detailed imaging characteristics can assist in determining outcomes when CYFMOS are treated with interventional percutaneous methods or surgical decompression with or without concomitant fusion.

Summary

CYFMOS although uncommon are not a rare finding seen in the spine when there is a background of degenerative spine changes. These cystic lesions are generally symptomatic by exhibiting mass effect on adjacent structure. Most treatments are aimed at decompression by interventional percutaneous or surgical means. Various imaging characteristics of these CYFMOS described in this article including their signal intensity, presence of spinal instability, particular patterns of adjacent degenerative changes, and imaging changes following interventional treatments can help guide physicians when managing these cases.

https://ift.tt/2NhK0ab

Telemedicine: a Primer

Abstract

Purpose of Review

Recent Findings

Summary

https://ift.tt/2wc6dQi

A Review of Portable Electronic Spirometers: Implications for Asthma Self-Management

Abstract

Purpose of Review

Recent Findings

Summary

This review found that providers' ability to make informed decisions about whether asthma patients may benefit from portable electronic spirometers is limited due to lack of patient outcome data.

https://ift.tt/2P4tF9e

Fronto Ethmoidal Mucocele Associated with Type 4 Kuhn Cells

Abstract

A mucocele is an epithelial lined mucous containing sac completely filling the sinus and capable of expansion. We report a case with unilateral frontoethmoidal mucocele in relation with type IV Kuhn cell. A 26 year old man came to the ENT department at SDUMC, Tamaka, Kolar, presenting complaints of proptosis of left eye since 3 years. After detailed examination and investigations patient was Diagnosed to have mucocele of left frontoethmoidal region. Intraoperatively we found a rare picture of type IV kuhn cells completely seated in the frontal sinus. After externally assisted modified Lothrop's approach, marsupialization of mucocele was done in the nasal cavity and symptoms of the patient relieved. We state that, in cases of frontoethmoidal mucocele, externally assisted modified Lothrop procedure offers an alternative for endoscopic management of frontoethmoidal mucocele for the complete clearance of disease.

https://ift.tt/2P5TgPa

Hearing Improvement in Interposition Ossiculoplasty and Myringostapediopexy

Abstract

Chronic otitis media (COM) may lead to partial or complete loss of tympanic membrane and erosion of the ossicles. Ossicular chain reconstruction may be done by interposition ossiculoplasty or myringostapediopexy. The aim of our study was to determine the hearing outcome in interposition ossiculoplasty and myringostapediopexy using autologous incus or cortical bone graft in intact canal wall tympanoplasty. 64 patients with COM, who underwent interposition ossiculoplasty or myringostapediopexy were included in the study. Audiometric evaluation was done after 3 months after surgery and all patients were followed up for a period of 1 year. The hearing results were compared in terms of mean pre-op and post-op Air conduction thresholds, Air-Bone gap (ABG) and hearing gain or ABG closure. In this study the mean ABG closure for interposition ossiculoplasty and myringostapediopexy was 15.4 dB and 21.8 dB, respectively. Hearing gain with cortical bone graft was higher than hearing gains with incus in both the groups, but not statistically significant. Myringostapediopexy provides marginally better hearing gain compared to interposition ossiculoplasty. Aulogous incus, and cortical bone graft are suitable autologous materials for ossicular reconstruction and provide similar hearing outcome.

https://ift.tt/2MAgX5p

Access to Round Window Niche via Posterior Tympanotomy and Impact of Drilling Its Overhangs: A Cadaveric Descriptive Study

Abstract

We intended to study the morphological parameters of round window region and assess the gain in exposure achieved by drilling the round window niche overhang. The Exposure of the round window membrane (RWM) is of prime importance to carry out atraumatic electrode insertion for cochlear implantation. The anatomy of round window has been a subject of considerable debate in literature. Fifty-one Formalin preserved adult cadaveric temporal bones were micro-dissected to carry out an 'optimal' posterior tympanotomy to expose the round window region. The bony overhangs of round window niche (RWN) were next drilled to achieve maximal possible exposure the RWM without violating the annulus of the same. The exposure was classified as per St Thomas' Hospital classification. The round window could not be visualized in 3 bones (5.9%). The commonest morphology of RWN was dome shaped, found in 18 (37.5%) and that of the RWM was oval shaped, found in 14 (29.2%) bones. Pre drilling 41 bones had a > 50% exposure of RWM while post drilling > 50% exposure could be achieved in all the bones except the 3 bones in which RWN could not be visualized to begin with. The drilling of the RWN overhangs exposed RWM in entirety in 91.7% of bones with a visible morphology of RWN pre drilling. RWN and RWM exhibit varied morphology. Drilling of the round window niche overhangs can considerably enhance the exposure of RWM.

https://ift.tt/2LoW87w

Obstructive sleep apnea, low transferrin saturation levels, and male‐pattern baldness

International Journal of Dermatology, EarlyView.

https://ift.tt/2Nk7xr7

Comorbidities or Different Entities? Phenotype Variability Associated with PSENEN Mutations

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

https://ift.tt/2MzWy0g

Preventability of SCARs

British Journal of Dermatology, Volume 179, Issue 2, Page e109-e109, August 2018.

https://ift.tt/2LtAU8m

Aspirin, folic acid and risk of basal cell carcinoma

British Journal of Dermatology, Volume 179, Issue 2, Page e110-e110, August 2018.

https://ift.tt/2MuYSFC

幼儿的角质层

British Journal of Dermatology, Volume 179, Issue 2, Page e125-e125, August 2018.

https://ift.tt/2P5UKc6

News and Notices

British Journal of Dermatology, Volume 179, Issue 2, Page 547-547, August 2018.

https://ift.tt/2MRtjFt

Differences in immune infiltrates in SCC under immunosuppression

British Journal of Dermatology, Volume 179, Issue 2, Page e101-e101, August 2018.

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酒渣鼻的流行病学

British Journal of Dermatology, Volume 179, Issue 2, Page e115-e115, August 2018.

https://ift.tt/2MuZB9O

Phospho flow cytometry of PBMCs in psoriasis

British Journal of Dermatology, Volume 179, Issue 2, Page e100-e100, August 2018.

https://ift.tt/2LqD6xl

Comparison of eczema severity measures

British Journal of Dermatology, Volume 179, Issue 2, Page e99-e99, August 2018.

https://ift.tt/2MMC7fH

Pyoderma gangrenosum and systemic treatment

British Journal of Dermatology, Volume 179, Issue 2, Page e98-e98, August 2018.

https://ift.tt/2LqD8oX

严重皮肤不良反应(SCAR)的可预防性

British Journal of Dermatology, Volume 179, Issue 2, Page e129-e129, August 2018.

https://ift.tt/2MKPygn

Demodex mites modulate sebocyte immune reaction

British Journal of Dermatology, Volume 179, Issue 2, Page e96-e96, August 2018.

https://ift.tt/2P4ikG5

阿司匹林、叶酸和基底细胞癌风险

British Journal of Dermatology, Volume 179, Issue 2, Page e130-e130, August 2018.

https://ift.tt/2MQDDgV

Cover Image: The manifestation of adult mite Sarcoptes scabiei under scanning electron microscope

British Journal of Dermatology, Volume 179, Issue 2, Page 545-546, August 2018.

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Children with facial morphoea managing everyday life

British Journal of Dermatology, Volume 179, Issue 2, Page e97-e97, August 2018.

https://ift.tt/2Mx96FB

The worldwide epidemiology of rosacea

British Journal of Dermatology, Volume 179, Issue 2, Page 239-240, August 2018.

https://ift.tt/2Lnm7vT

Corrigendum

British Journal of Dermatology, Volume 179, Issue 2, Page 546-546, August 2018.

https://ift.tt/2MQADBh

Biologics: targeting systemic inflammation in psoriasis

British Journal of Dermatology, Volume 179, Issue 2, Page 247-248, August 2018.

https://ift.tt/2P4iiOt

Issue Information

British Journal of Dermatology, Volume 179, Issue 2, Page i-vi, August 2018.

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Towards a better understanding of outcome measurement instruments for atopic eczema

British Journal of Dermatology, Volume 179, Issue 2, Page 246-247, August 2018.

https://ift.tt/2LoGbhv

Comparison of the efficacy and mechanisms of intranasal budesonide, montelukast, and their combination in treatment of patients with seasonal allergic rhinitis

International Forum of Allergy &Rhinology, EarlyView.

https://ift.tt/2o8gSHh

Fronto Ethmoidal Mucocele Associated with Type 4 Kuhn Cells

Abstract

https://ift.tt/2P5TgPa

Hearing Improvement in Interposition Ossiculoplasty and Myringostapediopexy

Abstract

https://ift.tt/2MAgX5p

Access to Round Window Niche via Posterior Tympanotomy and Impact of Drilling Its Overhangs: A Cadaveric Descriptive Study

Abstract

https://ift.tt/2LoW87w

Enhanced Therapeutic Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase 3 in a Murine Atopic Dermatitis‐Like Skin Inflammation Model

Allergy, Volume 0, Issue ja, -Not available-.

https://ift.tt/2Nh3mw2

Mapping of conformational IgE epitopes of food allergens

Allergy, Volume 0, Issue ja, -Not available-.

https://ift.tt/2PDHooK

Pulmonary function and bronchial reactivity 4 years after the first virus‐induced wheezing

Allergy, Volume 0, Issue ja, -Not available-.

https://ift.tt/2wplMn8

Time spent in an endemic area is a crucial clue to diagnose scrub typhus without eschar

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2wbbLe3

Reply to ‘Pruritic arthropod bite‐like papules in T‐cell large granular lymphocytic leukaemia and chronic myelomonocytic leukaemia’

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2P768EJ

Post‐bariatric surgery hidradenitis suppurativa: a new patient subset associated with malabsorption and micronutritional deficiencies

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2wbbrfl

Erythro-myeloid progenitors contribute endothelial cells to blood vessels

Plein, A; Fantin, A; Denti, L; Pollard, JW; Ruhrberg, C; (2018) Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature (In press).

https://ift.tt/2PDq3w2

Proof-of-concept study to establish an in situ method to determine the nature and depth of collagen changes in dentine using FTIR after sodium hypochlorite irrigation

Ng, YL; Gulabivala, K; Bozec, L; (2018) Proof-of-concept study to establish an in situ method to determine the nature and depth of collagen changes in dentine using FTIR after sodium hypochlorite irrigation. International Endodontic Journal (In press).

https://ift.tt/2Lozqwc

Using proxy responses from carers to collect quality of life data on patients with brain metastases: an analysis from the UK MRC quartz trial

Nankivell, M; Mulvenna, P; Barton, R; Faivre-Finn, C; Wilson, P; McColl, E; Moore, B; ... Stephens, R; + view all Nankivell, M; Mulvenna, P; Barton, R; Faivre-Finn, C; Wilson, P; McColl, E; Moore, B; Brisbane, I; Ardron, D; Stephens, R; - view fewer (2017) Using proxy responses from carers to collect quality of life data on patients with brain metastases: an analysis from the UK MRC quartz trial. Presented at: 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials, Liverpool, UK. Green open access

https://ift.tt/2MQyVQn

Comparing methods used to teach regression analysis to non-statisticians

Lee, SA; Wade, A; (2016) Comparing methods used to teach regression analysis to non-statisticians. In: Proceedings of the 9th Australian Conference on Teaching Statistics. OZCOTS: Canberra, Australia.

https://ift.tt/2Ls5JKV

A statistics module that interactively engages undergraduate medical students

Lee, SA; Koutoumanou, E; (2018) A statistics module that interactively engages undergraduate medical students. In: (Proceedings) International Conference of Teaching Statistics (ICOTS). International Association for Statistical Education (IASE)

https://ift.tt/2PzWThg

Narrative storytelling as mental health support for women experiencing gender-based violence in Afghanistan

Mannell, JC; Ahmad, L; Ahmad, A; (2018) Narrative storytelling as mental health support for women experiencing gender-based violence in Afghanistan. Social Science and Medicine 10.1016/j.socscimed.2018.08.011 . (In press).

https://ift.tt/2wptMoh

CFTR potentiation by VX-770 involves stabilization of the pre-hydrolytic, O1 state

Langron, E; Prins, S; Vergani, P; (2018) CFTR potentiation by VX-770 involves stabilization of the pre-hydrolytic, O1 state. British Journal of Pharmacology 10.1111/bph.14475 . (In press).

https://ift.tt/2MNkvQT

Space heating operation of combination boilers in the UK: The case for addressing real-world boiler performance:

Bennett, G; Elwell, C; Oreszczyn, T; (2018) Space heating operation of combination boilers in the UK: The case for addressing real-world boiler performance:. Building Services Engineering Research and Technology 10.1177/0143624418794552 . (In press). Green open access

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The Web-Based Interactive Mars Analysis and Research System for HRSC and the iMars Project

Walter, SHG; Muller, JP; Sidiropoulos, P; Tao, Y; Gwinner, K; Putri, ARD; Kim, JR; ... Schreiner, BP; + view all Walter, SHG; Muller, JP; Sidiropoulos, P; Tao, Y; Gwinner, K; Putri, ARD; Kim, JR; Steikert, R; van Gasselt, S; Michael, GG; Watson, G; Schreiner, BP; - view fewer (2018) The Web-Based Interactive Mars Analysis and Research System for HRSC and the iMars Project. Earth and Space Science , 5 (7) 10.1029/2018EA000389 . Green open access

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Consumer demand for time of use electricity tariffs: a systematized review of the empirical evidence

Nicolson, M; Fell, MJ; Huebner, G; (2018) Consumer demand for time of use electricity tariffs: a systematized review of the empirical evidence. Renewable and Sustainable Energy Reviews (In press).

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Evaluating the impact of a generalist teacher-led music program on early childhood school children’s singing skills and attitudes to music

Barrett, M; Zhukov, K; Brown, J; Welch, G; (2018) Evaluating the impact of a generalist teacher-led music program on early childhood school children's singing skills and attitudes to music. Psychology of Music 10.1177/0305735618790355 . (In press). Green open access

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First Population-Based Report of Infants with Congenital Diaphragmatic Hernia: 30-Day Outcomes from the American College of Surgeons National Quality Improvement Program

Zani-Ruttenstock, E; Zani, A; Eaton, SJ; Fecteau, A; (2019) First Population-Based Report of Infants with Congenital Diaphragmatic Hernia: 30-Day Outcomes from the American College of Surgeons National Quality Improvement Program. European Journal of Pediatric Surgery 10.1055/s-0038-1668563 . (In press).

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An automated workflow for segmenting single adult cardiac cells from large-volume serial block-face scanning electron microscopy data

Hussain, A; Ghosh, S; Kalkhoran, SB; Hausenloy, DJ; Hanssen, E; Rajagopal, V; (2018) An automated workflow for segmenting single adult cardiac cells from large-volume serial block-face scanning electron microscopy data. Journal of Structural Biology , 202 (3) pp. 275-285. 10.1016/j.jsb.2018.02.005 .

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The use of a cubesat to validate technological bricks in space

Rakotonimbahy, E; Vives, S; Dohlen, K; Savini, G; Iafolla, V; (2017) The use of a cubesat to validate technological bricks in space. In: (Proceedings) International Conference on Space Optics - ICSO 2014. SPIE Green open access

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Letter by Bulluck and Hausenloy Regarding Article, "Dynamic Edematous Response of the Human Heart to Myocardial Infarction: Implications for Assessing Myocardial Area at Risk and Salvage"

Bulluck, H; Hausenloy, DJ; (2018) Letter by Bulluck and Hausenloy Regarding Article, "Dynamic Edematous Response of the Human Heart to Myocardial Infarction: Implications for Assessing Myocardial Area at Risk and Salvage". Circulation , 137 (16) pp. 1748-1749. 10.1161/CIRCULATIONAHA.117.030974 .

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Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group

Goey, KKH; Sorbye, H; Glimelius, B; Adams, RA; Andre, T; Arnold, D; Berlin, JD; ... Koopman, M; + view all Goey, KKH; Sorbye, H; Glimelius, B; Adams, RA; Andre, T; Arnold, D; Berlin, JD; Bodoky, G; de Gramont, A; Diaz-Rubio, E; Eng, C; Falcone, A; Grothey, A; Heineman, V; Hochster, HS; Kaplan, RS; Kopetz, S; Labianca, R; Lieu, CH; Meropol, NJ; Price, TJ; Schilsky, RL; Schmoll, H-J; Shacham-Shmueli, E; Shi, Q; Sobrero, AF; Souglakos, J; van Cutsem, E; Zalcberg, J; van Oijen, MGH; Punt, CJA; Koopman, M; - view fewer (2018) Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group. European Journal of Cancer , 100 pp. 35-45. 10.1016/j.ejca.2018.05.010 .

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Outcomes of second-line antiretroviral therapy (ART) in HIV-infected children: a CIPHER cohort collaboration global analysis

Patel, K; Smith, C; Collins, IJ; Goodall, R; Abrams, E; Sohn, A; Mohamed, T; ... Vreeman, R; + view all Patel, K; Smith, C; Collins, IJ; Goodall, R; Abrams, E; Sohn, A; Mohamed, T; Van Dyke, R; Rojo, P; Wools-Kaloustian, K; Pinto, J; Edmonds, A; Marete, I; Paul, M; Nuwaqaba-Biribonwoha, H; Leroy, V; Davies, M-A; Vreeman, R; - view fewer (2018) Outcomes of second-line antiretroviral therapy (ART) in HIV-infected children: a CIPHER cohort collaboration global analysis. Presented at: 22nd International AIDS Conference, Amsterdam, the Netherlands. Green open access

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Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury

Ong, S-B; Katwadi, K; Kwek, X-Y; Ismail, NI; Chinda, K; Ong, S-G; Hausenloy, DJ; (2018) Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury. Expert Opinion on Therapeutic Targets , 22 (3) pp. 247-261. 10.1080/14728222.2018.1439015 .

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Maternal mental health and childhood injury: evidence from the UK Millennium Cohort Study

Hope, S; Deighton, J; Micali, N; Law, C; (2018) Maternal mental health and childhood injury: evidence from the UK Millennium Cohort Study. Archives of Disease in Childhood 10.1136/archdischild-2017-313809 . (In press). Green open access

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Σάββατο 25 Αυγούστου 2018

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