Response to: Comment on “Original Solution for Middle Ear Implant and Anesthetic/Surgical Management in a Child with Severe Craniofacial Dysmorphism”

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Burden of herpes zoster and postherpetic neuralgia in Japanese adults 60 years of age or older: Results from an observational, prospective, physician practice-based cohort study

Abstract

Approximately one in three persons will develop herpes zoster during their lifetime, and it can lead to serious complications such as postherpetic neuralgia. However, evidence on burden of herpes zoster and postherpetic neuralgia in Japan is limited. This prospective, observational, multicenter, physician practice-based cohort study was conducted in Kushiro, Hokkaido, Japan (Clinicaltrials.gov identifier NCT01873365) to assess the incidence and hospitalization rates of herpes zoster, and the proportion, clinical burden and risk factors for postherpetic neuralgia in adults aged 60 years or more. Within the study area, 800 subjects developed herpes zoster and 412 were eligible for the study. Herpes zoster incidence was 10.2/1000 person-years and higher among women and older subjects. Subjects with herpes zoster required on average 5.7 outpatient consultations. Herpes zoster-associated hospitalization rate was 3.4% (27/800). The proportion of postherpetic neuralgia and other complications was 9.2% (38/412) and 26.5% (109/412), respectively. Statistically significant association with the development of postherpetic neuralgia was male sex (odds ratio [OR], 2.51; 95% confidence interval [CI], 1.17–5.38), age of 70–74 years (OR, 3.51; 95% CI, 1.09–11.3), immunosuppressive therapy (OR, 6.44; 95% CI, 1.26–32.9), severe herpes zoster pain at first consultation (OR, 3.08; 95% CI, 1.10–8.62) and rash on upper arms (vs no rash on upper arms; OR, 3.46; 95% CI, 1.10–10.9). Considerable herpes zoster and postherpetic neuralgia burden exists among elderly in Japan, and there may be predictive factors at the first visit which could be indicative of the risk of developing postherpetic neuralgia.

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Neonatal airway obstruction in bilateral congenital dacryocystocoele: Case report and review of the literature

Publication date: January 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 92
Author(s): Tary Yin, Graeme van der Meer
Bilateral nasal obstruction due to simultaneous bilateral dacrocystocoeles is a rare and potentially life threatening condition. We present a five day old girl with this condition who presented with respiratory distress without any eye signs or symptoms associated with dacryocystocoeles. She was successfully managed with surgery and the clinical and radiological features of this condition are presented here with a review of the literature.



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Surgical scheduling categorization system (SSCS): A novel classification system to improve coordination and scheduling of operative cases in a tertiary pediatric medical system

Publication date: January 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 92
Author(s): Eric A. Gantwerker, Cassandra Bannos, Michael J. Cunningham, Reza Rahbar
ObjectiveTo describe a surgical categorization system to create a universal nomenclature, delineating patient complexity as a first step toward developing a true risk stratification system.MethodsRetrospective database review of all otolaryngology surgical procedures performed in a tertiary pediatric hospital system over one academic year (July 2012–June 2013). All otolaryngology surgical procedures were reviewed, encompassing 8478 procedures on 5711 patients. The attending otolaryngologist assigned surgical scheduling category (SSCS) at the time of case booking based on an institution specific guidelines. The guidelines are as follow: Category I was assigned to American Society of Anesthesiologists physical status classification (ASA) I/II patients, designating them appropriate for institution's suburban ambulatory surgery centers; Category II was ASA I/II patients with social or transportation issues; Category III was ASA I/II patients who required case coordination with other medical or surgical departments; Category IV was reserved for patients of any ASA class whom the surgeon designated to be of a higher complexity.Results8478 total procedures analyzed with 7198 having complete records. 48% were Category I, 13.6% were Category II, 1.9% were Category III and 36.5% were Category IV. The ASA were 34.7% ASA I, 50% ASA II, 13.39% ASA III, and 1.9% ASA IV. Although the largest proportion of patients were ASA II (50%), 39.6% of all ASA II were Category IV. Category IV was split into 54.2% ASA II and 34% ASA III and shows that peri-operative surgical concerns were not encompassed by the ASA system.ConclusionThis surgical categorization system streamlines surgical scheduling in a tertiary pediatric hospital system, particularly with respect to the designation of cases as ambulatory surgery center or main operating room appropriate. The case mix complexity is also readily apparent, enhancing recognition of the coordination and attention required for the perioperative management of high complexity patients. The SSCS helps convey concerns not addressed by ASA physical status alone.



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Subspecialist training program in pediatric otorhinolaryngology of UEMS ORL-HNS section

Publication date: Available online 5 December 2016
Source:International Journal of Pediatric Otorhinolaryngology
Author(s): Tomislav Baudoin
The ORL Section and Board of Otorhinolaryngology-Head and Neck Surgery of the European Union of Medical Specialists (UEMS) developed pediatric ORL subspecialty program. The program was created with support and consultation of the European Society of Pediatric Otorhinolaryngology. It is divided into four sections: Pediatric Otology, Pediatric Rhinology and Facial Plastic Surgery, Pediatric Laryngology and Phoniatrics and Pediatric Head and Neck Surgery. After completion of the program, the trainee is supposed to achieve an advanced level of competency. The aim of the program is to serve as a guideline for training centers, enabling them to meet the European Standard as set out by the European Board of UEMS through competency based assessments.



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Dry skin conditions are related to the recovery rate of skin temperature after cold stress rather than to blood flow

Abstract

Background

Cutaneous blood flow plays an important role in the thermoregulation, oxygen supply, and nutritional support necessary to maintain the skin. However, there is little evidence for a link between blood flow and skin physiology. Therefore, we conducted surveys of healthy volunteers to determine the relationship(s) between dry skin properties and cutaneous vascular function.

Methods

Water content of the stratum corneum, transepidermal water loss, and visual dryness score were investigated as dry skin parameters. Cutaneous blood flow in the resting state, the recovery rate (RR) of skin temperature on the hand after a cold-stress test, and the responsiveness of facial skin blood flow to local cooling were examined as indices of cutaneous vascular functions. The relationships between dry skin parameters and cutaneous vascular functions were assessed.

Results

The RR correlated negatively with the visual dryness score of skin on the leg but correlated positively with water content of the stratum corneum on the arm. No significant correlation between the resting state of blood flow and dry skin parameters was observed. In both the face and the body, deterioration in skin dryness from summer to winter was significant in subjects with low RR. The RR correlated well with the responsiveness of facial skin blood flow to local cooling, indicating that the RR affects systemic dry skin conditions.

Conclusions

These results suggest that the RR but not blood flow at the resting state is associated with dry skin conditions and is involved in skin homeostasis during seasonal environmental changes.

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Co-distribution of cysteine cathepsins and matrix metalloproteases in human dentin

Publication date: February 2017
Source:Archives of Oral Biology, Volume 74
Author(s): Polliana Mendes Candia Scaffa, Lorenzo Breschi, Annalisa Mazzoni, Cristina de Mattos Pimenta Vidal, Rosa Curci, Fabianni Apolonio, Pietro Gobbi, David Pashley, Leo Tjäderhane, Ivarne Luis dos Santos Tersariol, Fábio Dupart Nascimento, Marcela Rocha Carrilho
It has been hypothesized that cysteine cathepsins (CTs) along with matrix metalloproteases (MMPs) may work in conjunction in the proteolysis of mature dentin matrix. The aim of this study was to verify simultaneously the distribution and presence of cathepsins B (CT-B) and K (CT-K) in partially demineralized dentin; and further to evaluate the activity of CTs and MMPs in the same tissue. The distribution of CT-B and CT-K in sound human dentin was assessed by immunohistochemistry. A double-immunolabeling technique was used to identify, at once, the occurrence of those enzymes in dentin. Activities of CTs and MMPs in dentin extracts were evaluated spectrofluorometrically. In addition, in situ gelatinolytic activity of dentin was assayed by zymography. The results revealed the distribution of CT-B and CT-K along the dentin organic matrix and also indicated co-occurrence of MMPs and CTs in that tissue. The enzyme kinetics studies showed proteolytic activity in dentin extracts for both classes of proteases. Furthermore, it was observed that, at least for sound human dentin matrices, the activity of MMPs seems to be predominant over the CTs one.



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Relative costs of anesthesiologist prepared, hospital pharmacy prepared and outsourced anesthesia drugs

Anesthesia drugs can be prepared by anesthesia providers, hospital pharmacies or outsourcing facilities. The decision whether to outsource all or some anesthesia drugs is challenging since the costs associated with different anesthesia drug preparation methods remain poorly described.

http://ift.tt/2gRbFyX

Intravenously administered gene therapy for the treatment of neuronopathic Gaucher Disease

Massaro, G; Perocheau, D; Baker, R; Karlsson, S; Cheng, S; Waddington, S; Rahim, A; (2016) Intravenously administered gene therapy for the treatment of neuronopathic Gaucher Disease. In: (Proceedings) Annual Conference of the British-Society-for-Gene-and-Cell-Therapy. (pp. A10-A10). MARY ANN LIEBERT, INC

http://ift.tt/2gUjV3S

Development of gene therapy for Niemann-Pick Type C disease

Hughes, M; Smith, D; Morris, L; Tordo, J; Palomar-Martin, N; Henckaerts, E; Waddington, S; Hughes, M; Smith, D; Morris, L; Tordo, J; Palomar-Martin, N; Henckaerts, E; Waddington, S; Platt, F; Rahim, A; - view fewer (2016) Development of gene therapy for Niemann-Pick Type C disease. In: (Proceedings) Annual Conference of the British-Society-for-Gene-and-Cell-Therapy. (pp. A14-A14). MARY ANN LIEBERT, INC

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An evaluation of lentiviral mediated gene delivery to Schwann cells for the purpose of tissue engineering

Busuttil, F; Hughes, M; Bhangra, KS; Phillips, J; Rahim, A; (2016) An evaluation of lentiviral mediated gene delivery to Schwann cells for the purpose of tissue engineering. In: (Proceedings) Annual Conference of the British-Society-for-Gene-and-Cell-Therapy. (pp. A19-A20). MARY ANN LIEBERT, INC

http://ift.tt/2gUks65

Thermoelectric and electrical transport in mesoscopic two-dimensional electron gases

Narayan, V; Pepper, M; Ritchie, DA; (2016) Thermoelectric and electrical transport in mesoscopic two-dimensional electron gases. COMPTES RENDUS PHYSIQUE , 17 (10) pp. 1123-1129. 10.1016/j.crhy.2016.08.012 .

http://ift.tt/2fYMWqv

The Rebound Effect in Home Heating: A Guide for Policymakers and Practitioners

Hamilton, IG; (2016) The Rebound Effect in Home Heating: A Guide for Policymakers and Practitioners. BUILDING RESEARCH AND INFORMATION , 44 (8) pp. 935-938. 10.1080/09613218.2016.1174909 .

http://ift.tt/2gUsiMP

The Classification of Protein Domains.

Dawson, N; Sillitoe, I; Marsden, RL; Orengo, CA; (2017) The Classification of Protein Domains. Methods Mol Biol , 1525 pp. 137-164. 10.1007/978-1-4939-6622-6_7 .

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