Publication date: Available online 13 June 2018
Source:Allergology International
Author(s): Satoshi Nakamura, Sachiko Tsunoda, Hiroshi Sakaida, Sawako Masuda, Ahamad Shah Said, Kazuhiko Takeuchi
BackgroundGenetic and environmental factors are proposed to be involved in cedar pollen allergy sensitization and onset. The impact of these factors will provide key information for the prevention of cedar pollen sensitization and allergy onset, which we investigated in this cross-sectional study.MethodsSubjects were 382 young adult volunteers who completed a self-administered questionnaire on self-reported subjective symptoms of pollinosis, physician-diagnosed pollinosis, and background factors. We also measured their serum IgE antibody titers specific for cedar, cypress, and mites. Factors associated with subjective symptoms, physician diagnosis, and the three specific antigens were determined using both univariate and multivariate analyses.ResultsSensitization to cedar, cypress, and mites, defined as specific IgE levels of class 1 or above, was found in 78.8%, 64.4%, and 56.0% of subjects, respectively. The prevalence of cedar pollinosis was 41.2% based on subjective symptoms and 22.2% based on physician diagnosis. Factors associated with increased cedar pollen sensitization were mite sensitization, comorbid allergic rhinitis, and family history of cedar pollinosis. Risk-reducing factors for cedar pollen sensitization were keeping a cat, number of common colds, and hours of sleep. Risk-increasing factors for both subjective pollinosis symptoms and physician-diagnosed pollinosis were comorbid allergic rhinitis and family history of cedar pollinosis.ConclusionsSensitization to cedar pollen in this population was extremely high. Both common and distinct factors were associated with sensitization to pollen and with the development of pollinosis. The distinct factors were associated with sensitization to cedar and cypress antigens.
https://ift.tt/2l43kuO
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Τρίτη 12 Ιουνίου 2018
Analysis of factors associated with cedar pollen sensitization and development of pollinosis in a young Japanese adult population
Hypofractionated Radiotherapy Is Superior to Conventional Fractionation in an Orthotopic Model of Anaplastic Thyroid Cancer
Thyroid, Volume 28, Issue 6, Page 739-747, June 2018.
https://ift.tt/2JN1QU2
NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland
Thyroid, Volume 28, Issue 6, Page 780-798, June 2018.
https://ift.tt/2LK25MJ
Thyroid Incidentalomas Detected on 18F-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography: Malignant Risk Stratification and Management Plan
Thyroid, Volume 28, Issue 6, Page 762-768, June 2018.
https://ift.tt/2JPLSYY
Theo J. Visser, PhD (September 17, 1949–March 21, 2018)
Thyroid, Volume 28, Issue 6, Page 687-689, June 2018.
https://ift.tt/2JRgx8r
Excessive Iodine Intake and Subclinical Hypothyroidism in Children and Adolescents Aged 6–19 Years: Results of the Sixth Korean National Health and Nutrition Examination Survey, 2013–2015
Thyroid, Volume 28, Issue 6, Page 773-779, June 2018.
https://ift.tt/2HGM5sB
RSS Story 01
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Current and future challenges of subcutaneous and sublingual allergy immunotherapy for allergists in the United States
Source:Annals of Allergy, Asthma & Immunology
Author(s): Harold S. Nelson
https://ift.tt/2Mm1YYZ
A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity
An 82-year-old female presented with multiple oral ulcers and malena for 1 week. Her laboratory tests revealed pancytopenia and acute renal failure. She had history of rheumatoid arthritis for which she was taking 7.5 mg methotrexate weekly and stage 4 chronic kidney disease from diabetic nephropathy. During the hospital stay, she developed pneumonia and septic shock requiring norepinephrine and vasopressin. She underwent continuous venovenous hemodiafiltration. Leucovorin, filgrastim, and multiple packed red blood cell and platelet transfusions were given. She remained hypotensive and pancytopenic despite all interventions. She died on day 6 of hospital stay from acute hypoxic respiratory failure due to septic shock.
https://ift.tt/2sRkgJs
Summer Fun for the Family | Your Guide to Having a Blast!
Summer creates many opportunities to get outside, be active, and try something new as a family. Often one of the biggest barriers to this is – yes, you guessed it – the heat! Other times, it may be that your family is very busy with various commitments or your child is too glued to the TV/phone/computer/video gaming system that they don't want to do anything else.
Yes, these can all make it challenging at times, but at the end of the day, there are many family-friendly activities available in the warmer months to be taken advantage of before the season passes. The benefits of being outside and active with your kids are wide-ranging and include promoting an improved mood, better sleep, relationship building, and modeling a healthy lifestyle for your child.
Here are a few ideas to help you and your family have a fun-filled summer –
Ask Your Child for Ideas
Have your child brainstorm various activities they'd like to do or try over the summer – within reason. For example, if your child loves animals, then trips to the zoo, to volunteer at an animal shelter, or going horseback riding might be fun activities to pursue. If your child loves being creative, then they might enjoy taking an art class or making a fun art project at home. If your child is into sports, then playing catch, going to the batting cages, or trying a new sport together could be fun.
Research on Your Own
Perhaps there are events or activities around town you've always meant to take the family to but never seem to make it, such as summer festivals, farmers markets, or a local semi- or professional baseball game. Maybe you've heard about friends going on a family canoeing or float trip and you always thought that would be fun. Do some searching to see if there are local events in your community or around the city you or your family would be interested in and then make a plan to attend.
Be Creative with Your Plans
Not every activity needs to involve spending money or a large family trip/outing. Having a water balloon battle outside, going for a walk/bike ride in the park, turning your driveway into a chalk-drawn masterpiece, or sharing a favorite activity from your own childhood with your child (e.g., fishing, flying a kite, building pillow forts, catching fireflies, roller-blading/roller-skating, and so on) are all ways to share time, activity, and enjoy the season.
The post Summer Fun for the Family | Your Guide to Having a Blast! appeared first on ChildrensMD.
https://ift.tt/2MlbwTS
Embracing early recovery after surgery (ERAS) protocols: Is it time for otolaryngology to join the parade?
As an academic, clinical and/or investigative surgical specialist, one must embrace the ethical imperative for health care professionals to promulgate refinements in perioperative care that would improve patient outcomes. This editorial comment has been provided to the American Journal of Otolaryngology because clinical and research interactions with the U.S. Department of Defense have demonstrated an interface between nutritional science and hearing disorders [1–3] at a time when there are important changes occurring in the perioperative environment.
https://ift.tt/2t4pOzo
Current and future challenges of subcutaneous and sublingual allergy immunotherapy for allergists in the United States
Both subcutaneous and sublingual allergy immunotherapy (SCIT and SLIT, respectively) for inhalant allergens have proven efficacy for allergic rhinitis and allergic asthma, with limited support for efficacy in selected patients with atopic dermatitis.1 Both SCIT and SLIT have been shown to modify the immunologic defect underlying the allergic respiratory diseases,2 an effect that is clinically manifest by suppression of new sensitization in monosensitized patients, reduction in the development of asthma in those only having allergic rhinitis, and persistence of clinical improvement for years after an adequate course of treatment.
https://ift.tt/2l3AsmB
Idelalisib in a patient with refractory Waldenström’s macroglobulinemia complicated by anuric renal failure: a case report
Waldenström's macroglobulinemia is a rare B-cell lymphoma. The gold standard treatment for Waldenström's macroglobulinemia is an anti-CD20 antibody (rituximab) in combination with alkylating agents and dexamet...
https://ift.tt/2l95rNX
Role of sublingual immunotherapy in the treatment of asthma: An updated systematic review
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2l9r8hf
Nasal physiology: improving our understanding in the health and disease
International Forum of Allergy &Rhinology, Volume 8, Issue 6, Page 666-667, June 2018.
https://ift.tt/2t25miJ
Issue Information
International Forum of Allergy &Rhinology, Volume 8, Issue 6, Page 659-661, June 2018.
https://ift.tt/2l84UMq
Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2t25iiZ
Accessory maxillary ostium repair using middle turbinate flap: a case series of 116 patients with chronic rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2l3H8RB
Size of septectomy does not affect distribution of nasal irrigation after endoscopic modified Lothrop procedure
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2y603Vr
New observations regarding Helicobacter pylori and gastric cancer in Mongolia
Helicobacter, EarlyView.
https://ift.tt/2l6iTCi
The effect of light intensity on image quality in endoscopic ear surgery
Clinical Otolaryngology, EarlyView.
https://ift.tt/2JE4FTM
Circulating human papillomavirus DNA as a surveillance tool in head and neck squamous cell carcinoma: A systematic review and meta‐analysis
Clinical Otolaryngology, EarlyView.
https://ift.tt/2MmDuio
Cochlear implantation using a custom guide catheter in 14 patients with incomplete partition type III
Clinical Otolaryngology, EarlyView.
https://ift.tt/2y5SCNR
Intralesional steroid injection as an alternative treatment for 57 patients of vocal fold mucus retention cysts
Clinical Otolaryngology, EarlyView.
https://ift.tt/2JxWLzt
Biofilm in voice prosthesis: A prospective cohort study and laboratory tests using sonication and SEM analysis
Clinical Otolaryngology, EarlyView.
https://ift.tt/2y5StKj
Correction for Zhu et al., CSI1, PATROL1, and exocyst complex cooperate in delivery of cellulose synthase complexes to the plasma membrane [Correction]
PLANT BIOLOGY Correction for "CSI1, PATROL1, and exocyst complex cooperate in delivery of cellulose synthase complexes to the plasma membrane," by Xiaoyu Zhu, Shundai Li, Songqin Pan, Xiaoran Xin, and Ying Gu, which was first published March 26, 2018; 10.1073/pnas.1800182115 (Proc Natl Acad Sci USA 115:E3578–E3587). The authors note that...
https://ift.tt/2LMs1qX
Reply to Queimado et al.: E-cigarettes induce DNA damage and inhibit DNA repair in mice and human cells [Biological Sciences]
We believe that Queimado et al. (1) may have inadvertently missed several key details presented in our recent PNAS publication (2). First, for the determination of nicotine effects on DNA adduct formation and DNA repair activity, the nicotine concentrations used for 1-h treatments of human lung and bladder epithelial cells...
https://ift.tt/2JMJWk4
Transcriptional signature of the decidua in preeclampsia [Biological Sciences]
An emerging concept is that the genesis of preeclampsia is rooted in dysregulated decidualization (1). In PNAS, Garrido-Gomez et al. (2) demonstrate a distinct transcriptional signature in the endometrial stromal cells (ESCs) of preeclampsia patients compared with control cells during in vitro decidualization (before pregnancy) and in vivo decidualization (after...
https://ift.tt/2JOigvb
Electronic cigarette aerosols induce DNA damage and reduce DNA repair: Consistency across species [Biological Sciences]
We read with great interest the work of Lee et al. (1), in which the authors report that mice exposed to electronic cigarette aerosol have increased levels of DNA lesions and decreased DNA repair activity. This work sparked important discussion both in PNAS (2, 3) and science media (4). We...
https://ift.tt/2HJhXNc
Correction for Spence et al., Revealing the specificity of regulatory T cells in murine autoimmune diabetes [Correction]
IMMUNOLOGY AND INFLAMMATION Correction for "Revealing the specificity of regulatory T cells in murine autoimmune diabetes," by Allyson Spence, Whitney Purtha, Janice Tam, Shen Dong, Youmin Kim, Chia-Hsin Ju, Teague Sterling, Maki Nakayama, William H. Robinson, Jeffrey A. Bluestone, Mark S. Anderson, and Qizhi Tang, which was first published April...
https://ift.tt/2JKhxuX
Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning [Neuroscience]
C1q, a member of the immune complement cascade, is implicated in the selective pruning of synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown to occur during brain development, while increased activation and complement-dependent synapse loss is observed in neurodegenerative diseases. However, the molecular mechanisms underlying C1q-controlled synaptic pruning...
https://ift.tt/2LMXOIH
Navigation of brain networks [Neuroscience]
Understanding the mechanisms of neural communication in large-scale brain networks remains a major goal in neuroscience. We investigated whether navigation is a parsimonious routing model for connectomics. Navigating a network involves progressing to the next node that is closest in distance to a desired destination. We developed a measure to...
https://ift.tt/2JKhyz1
Functional diversification of Arabidopsis SEC1-related SM proteins in cytokinetic and secretory membrane fusion [Plant Biology]
Sec1/Munc18 (SM) proteins contribute to membrane fusion by interacting with Qa-SNAREs or nascent trans-SNARE complexes. Gymnosperms and the basal angiosperm Amborella have only a single SEC1 gene related to the KEULE gene in Arabidopsis. However, the genomes of most angiosperms including Arabidopsis encode three SEC1-related SM proteins of which only...
https://ift.tt/2JPuHa2
KDM4B protects against obesity and metabolic dysfunction [Medical Sciences]
Although significant progress has been made in understanding epigenetic regulation of in vitro adipogenesis, the physiological functions of epigenetic regulators in metabolism and their roles in obesity remain largely elusive. Here, we report that KDM4B (lysine demethylase 4B) in adipose tissues plays a critical role in energy balance, oxidation, lipolysis,...
https://ift.tt/2sSSImV
Transcription factor profiling reveals molecular choreography and key regulators of human retrotransposon expression [Biophysics and Computational Biology]
Transposable elements (TEs) represent a substantial fraction of many eukaryotic genomes, and transcriptional regulation of these factors is important to determine TE activities in human cells. However, due to the repetitive nature of TEs, identifying transcription factor (TF)-binding sites from ChIP-sequencing (ChIP-seq) datasets is challenging. Current algorithms are focused on...
https://ift.tt/2sXHSwf
Two-way mixed-effects methods for joint association analysis using both host and pathogen genomes [Statistics]
Infectious diseases are often affected by specific pairings of hosts and pathogens and therefore by both of their genomes. The integration of a pair of genomes into genome-wide association mapping can provide an exquisitely detailed view of the genetic landscape of complex traits. We present a statistical method, ATOMM (Analysis...
https://ift.tt/2LKHYht
Doc2-mediated superpriming supports synaptic augmentation [Neuroscience]
Various forms of synaptic plasticity underlie aspects of learning and memory. Synaptic augmentation is a form of short-term plasticity characterized by synaptic enhancement that persists for seconds following specific patterns of stimulation. The mechanisms underlying this form of plasticity are unclear but are thought to involve residual presynaptic Ca2+. Here,...
https://ift.tt/2JtdMe2
Mapping an ancient city with a century of remotely sensed data [Anthropology]
The rapidly growing global population places cultural heritage at great risk, and the encroachment of modern settlement on archaeological sites means that valuable information about how past societies worked and interacted with the environment is lost. To manage and mitigate these risks, we require knowledge about what has been lost...
https://ift.tt/2JMie77
Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis [Medical Sciences]
Mesenchymal cells in the microenvironment of cancer exert important functions in tumorigenesis; however, little is known of intrinsic pathways that mediate these effects. MAPK signals, such as from MAPKAPK2 (MK2) are known to modulate tumorigenesis, yet their cell-specific role has not been determined. Here, we studied the cell-specific role of...
https://ift.tt/2sTljZn
Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus Colletotrichum [Agricultural Sciences]
Species in the genus Cercospora cause economically devastating diseases in sugar beet, maize, rice, soy bean, and other major food crops. Here, we sequenced the genome of the sugar beet pathogen Cercospora beticola and found it encodes 63 putative secondary metabolite gene clusters, including the cercosporin toxin biosynthesis (CTB) cluster....
https://ift.tt/2LMY4r9
Maturation of polycistronic mRNAs by the endoribonuclease RNase Y and its associated Y-complex in Bacillus subtilis [Microbiology]
Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its cleavage activity toward the cggR-gapA operon, an event that differentiates the synthesis of a glycolytic enzyme from...
https://ift.tt/2JxNeZd
Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1 [Applied Biological Sciences]
T cell-engaging bispecific antibodies (biAbs) present a promising strategy for cancer immunotherapy, and numerous bispecific formats have been developed for retargeting cytolytic T cells toward tumor cells. To explore the therapeutic utility of T cell-engaging biAbs targeting the receptor tyrosine kinase ROR1, which is expressed by tumor cells of various...
https://ift.tt/2JPsBXR
Mediator subunit MED31 is required for radial patterning of Arabidopsis roots [Plant Biology]
Stem cell specification in multicellular organisms relies on the precise spatiotemporal control of RNA polymerase II (Pol II)-dependent gene transcription, in which the evolutionarily conserved Mediator coactivator complex plays an essential role. In Arabidopsis thaliana, SHORTROOT (SHR) and SCARECROW (SCR) orchestrate a transcriptional program that determines the fate and asymmetrical...
https://ift.tt/2JxN8kj
In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking [Biochemistry]
Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction, first cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate and then joining...
https://ift.tt/2LMY2j1
Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation [Immunology and Inflammation]
Immediate β2-integrin activation upon T cell receptor stimulation is critical for effective interaction between T cells and their targets and may therefore be used for the rapid identification and isolation of functional T cells. We present a simple and sensitive flow cytometry-based assay to assess antigen-specific T cells using fluorescent...
https://ift.tt/2HHomZn
Postoperative wound infection rates following diagnostic skin biopsies in dermatology patients at an Australian tertiary hospital
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2JJ0zd2
Issue Information ‐ TOC
Allergy, Volume 73, Issue 6, Page 1149-1150, June 2018.
https://ift.tt/2t3tbXo
Issue Information ‐ Cover and Editorial Board
Allergy, Volume 73, Issue 6, Page 1147-1147, June 2018.
https://ift.tt/2l4GuDq
The treatment of hyaluronic acid aesthetic interventional induced visual loss (AIIVL): A consensus on practical guidance
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2JFvyab
Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates
Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue S2, Page 5-14, June 2018.
https://ift.tt/2l7aHSy
Two important novelties in etiopathogenesis and therapy of acne
Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue S2, Page 3-4, June 2018.
https://ift.tt/2yeEKBd
Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine®
Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue S2, Page 15-23, June 2018.
https://ift.tt/2l9bylL
Issue Information
Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue S2, Page 1-2, June 2018.
https://ift.tt/2y4TPFn
Dyschromatosis symmetrica hereditaria with chilblains due to a novel two‐amino‐acid deletion in the double‐stranded RNA‐binding domain of ADAR1
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2l3l9dF
Mucosal melanoma: clinical and genetic profile
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2t1NLHF
A review of non‐invasive imaging in extramammary Paget's disease
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2l3kWXV
Inflammatory cytokines and peripheral mediators in the pathophysiology of pruritus in cutaneous T‐cell lymphoma
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2ybojFo
The Jarisch–Herxheimer reaction in syphilis: could molecular typing help to understand it better?
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2l6bfYU
Which acne treatment has the best influence on health‐related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2t1NjZZ
Response: field cancerization and koebnerized skin tumours
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2l9bvX7
Longitudinal subungual acanthoma: one denomination for various clinical presentations
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2t2AU8m
Reply to mucosal melanoma: clinical and genetic profile
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2l6Npfu
Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2y6sLFr
Prurigo Activity Score (PAS): validity and reliability of a new instrument to monitor chronic prurigo
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2l6b67O
Evaluation of the appropriate surgical margin for pigmented basal cell carcinoma according to the risk factors for recurrence: a single‐institute retrospective study in Japan
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2t2Rc0T
Teledermatology‐driven topical therapy of actinic keratosis: a comparative study of clinical effectiveness and compliance
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2l6aW0c
Metastatic tubercular gummas and splenic tuberculoma secondary to tubercular lymphadenitis in an immunocompetent female
International Journal of Dermatology, EarlyView.
https://ift.tt/2t2qo0V
The global prevalence and correlates of skin bleaching: a meta‐analysis and meta‐regression analysis
International Journal of Dermatology, EarlyView.
https://ift.tt/2l66i1Y
A large shagreen patch with overlying verrucous epidermal naevus: a curious case of colocalization
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JvIoMe
Acquired reactive perforating collagenosis associated with mediastinal synovial sarcoma
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2y4pSFh
Borst–Jadassohn phenomenon arising from a seborrhoeic keratosis and its characteristic dermoscopic features
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JvIfIG
Idiopathic thrombocytopenic purpura in a patient with IgG4‐related disease
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2ybRhW2
Biologic therapy: a boon for hidradenitis suppurativa‐like lesions complicating naevus comedonicus in a prepubertal child
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JvteWZ
A novel frameshift SERPINB7 mutation in a Chinese case with Nagashima‐type palmoplantar keratosis: case report and review of the literature
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JCBQHj
Genetic association between the NLRP3 gene and acne vulgaris in a Chinese population
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2MmIFPg
A dog's life: an unfamiliar and lethal side effect of topical 5‐fluorouracil
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2y4JsB8
pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury
The Laryngoscope, EarlyView.
https://ift.tt/2JIUQYh
First case of chronic cutaneous chromoblastomycosis by Rhinocladiella similis aquired in Europe
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2MiFwQq
Utility of tissue elafin as an immunohistochemical marker for diagnosis of acute skin graft‐versus‐host disease: a pilot study
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2ybR7xU
Novel treatment of painful plantar keratoderma in pachyonychia congenita using topical sirolimus
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JySITu
Confirmation of the role of a KRT5 mutation and successful management of skin lesions in a patient with Galli–Galli disease
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JE3XpG
Axillary web syndrome following epidermal inclusion cyst: a case report and literature review
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JzZzvO
Permanent alopecia as a manifestation of chronic graft‐versus‐host disease of the scalp: clinical, dermoscopic and histopathological observations
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JDuOlH
A case of gamasoidosis caused by Dermanyssus gallinae, misdiagnosed as delusional parasitosis
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2Jv1Okd
An unusual eruption following herpes zoster infection
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2y5AIef
Benefit of electron beam therapy in combination with medium‐dose systemic corticosteroid as a palliative treatment for elderly patients with blastic plasmacytoid dendritic cell neoplasm: case report and review of the literature
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2JzZd8s
Dermoscopic patterns of early‐stage mycosis fungoides in a Chinese population
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2y4pDKn
Treatment of halo naevus with the topical Janus kinase inhibitor tofacitinib 1.5%
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2Mivxui
Why a randomized melanoma screening trial is not a good idea
British Journal of Dermatology, EarlyView.
https://ift.tt/2JJ8YR8
T helper 17 cell/regulatory T‐cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities
British Journal of Dermatology, EarlyView.
https://ift.tt/2HIbr9A
New additions to the bookshelf: Vulval Disease
British Journal of Dermatology, EarlyView.
https://ift.tt/2JJ8HxA
Erythropoietic protoporphyria and solar urticarial
British Journal of Dermatology, EarlyView.
https://ift.tt/2LMLYyf
Diagnostic accuracy of dermatofluoroscopy in cutaneous melanoma detection: results of a prospective multicentre clinical study in 476 pigmented lesions
British Journal of Dermatology, EarlyView.
https://ift.tt/2JRROkB
Widespread regular sunscreen application deemed not useful in the U.S.A.: reply from authors
British Journal of Dermatology, EarlyView.
https://ift.tt/2HHoOqr
Widespread regular sunscreen application deemed not useful in the U.S.A.
British Journal of Dermatology, EarlyView.
https://ift.tt/2JRRC4R
Erectile Dysfunction Means Increased Risk for Heart Disease, Regardless of Other Risk Factors
https://ift.tt/2l526Qf
Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease
Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2l2NqB8
Insights in particulate matter‐induced allergic airway inflammation: Focus on the epithelium
Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2y3QTZh
Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma
Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2l6CPFj
Phase 2a, randomized, double‐blind, placebo‐controlled, multicentre, parallel‐group study of an H4R‐antagonist (JNJ‐39758979) in adults with uncontrolled asthma
Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2y3QLsL
IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma
Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2l745Ue
Sputum‐to‐serum hydrogen sulphide ratio as a novel biomarker of predicting future risks of asthma exacerbation
Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2t0b3On
The roles for innate lymphoid cells in the human immune system
Abstract
From constituting a novel and obscure cell population, innate lymphoid cells (ILCs) are now accepted as a self-evident part of the immune system, contributing with unique and complementary functions to immunity by production of effector cytokines and interaction with other cell types. In this review, we discuss the redundant and complementary roles of the highly plastic human ILCs and their interaction with other immune cells with the ultimate aim of placing ILCs in a wider context within the human immune system.
https://ift.tt/2sTLHCk
Wet and wounded: Pediatric facial trauma from swimming and diving
Publication date: August 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 111
Author(s): Nicholas P. Guys, Ahsan Mir, Peter F. Svider, Anthony Sheyn
ObjectivesSwimming has been reported as the most common recreational activity among American youths, while diving remains a popular youth activity as well. We characterize the most common facial injuries occurring during these activities and evaluate facial fracture mechanisms and demographic trends, as this information may be helpful in preventative counseling as well as diagnosis.MethodsThe National Electronic Injury Surveillance System was assessed for swimming- and diving-related facial injuries in children from 2007 to 2016. Estimates of national injury incidence were recorded, and patient diagnoses, demographics, and injury mechanisms were evaluated.ResultsIn the 10-year period assessed, 789 NEISS entries extrapolated to an estimated 27,709 patients nationwide were analyzed. The yearly incidence fluctuated but steadily rose from 2013 to 2016. Males comprised a majority of injuries (58%), and laceration was the most common diagnosis (65%), followed by abrasion/contusion (22%) and fracture (9%). Facial fractures were most likely to involve the nasal bones (87%). Swimming injuries were more numerous overall (74%), but a greater proportion of diving injuries resulted in fracture (12% vs. 7%). Teenagers were also more likely to suffer fractures than were younger children involved in the same activities.ConclusionMost analyses of swimming and diving injuries have focused on spinal and orthopedic trauma. Nevertheless, the nature of headfirst diving and swim strokes suggest facial trauma is an underappreciated concern for clinicians. These findings reinforce the need for safer swimming and diving practices and serve as a useful resource for physicians managing pediatric facial injuries.
https://ift.tt/2HF3uBX
Transnasal adenoidectomy in mucopolysaccharidosis
Source:International Journal of Pediatric Otorhinolaryngology, Volume 111
Author(s): Rebecca Harrison, Simone Schaefer, Laura Warner, Jean Mercer, Simon Jones, Iain Bruce
BackgroundMucopolysaccharide (MPS) diseases are a heterogeneous group of inherited, metabolic disorders characterized by accumulation of partially degraded glycosaminoglycans (GAG) in multiple organ systems. Due to accumulation in the airway, patients often present with multilevel airway obstruction and obstructive sleep apnoea (OSA). Adenotonsillar surgery leads to a significant improvement in the severity of OSA in MPS patients. However, access to secure the airway and for conventional surgery can be challenging, due to limited neck extension, macroglossia and reduced mouth opening. This study was undertaken to evaluate the role of transnasal microdebridement and radiofrequent plasma ablation (Coblation) in adenoidectomy to treat OSA in patients with MPS and restricted airway access.MethodsA retrospective case review was performed including patients with MPS undergoing adenoidectomy for OSA in the period between June 2015 and March 2017. In all cases, either a microdebrider (Gyrus Diablo) or a Coblation wand (EVAC70, Smith&Nephew) was used via a transnasal approach guided by nasendoscopy. The primary outcome was effect upon OSA, measured by sleep oximetry and parental report of benefit. The secondary outcomes were surgical complications and risk factors for persistent OSA after surgery.ResultsA total of nine patients were identified with a mean age of 9 years (range 3–14 years) at surgery. Post-operative sleep study data was available for eight patients (8/9). Six patients (6/8) had improvement in 4% oxygen desaturation index (ODI-4) with a mean of 8.11 pre-operatively (range 2.69–14.0) and 4.99 postoperatively (range 0.68–8.48). ODI-4 did not improve in two (2/8) patients. Irrespective of sleep oximetry results, improvement in OSA-related symptoms was noted by all parents postoperatively. No risk factors for persistent OSA were identified. Furthermore, no complications were noted in this cohort.ConclusionTransnasal Coblation and Microdebrider adenoidectomy is a safe and effective surgical treatment for OSA in patients with Mucopolysaccharidosis and adenoidal hypertrophy. As lifespan increases for patients with the Mucopolysaccharidoses, greater emphasis is being given to optimising airway management over the longer-term. This technical note describes the novel application of endoscopic techniques for the management of primary adenoidal hypertrophy when transoral access is restricted, or to debulk recurrent disease that would be challenging to remove via the standard transoral route.
https://ift.tt/2JMP0EZ
Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC
Interventions: Other: Robust Radiotherapy planning; Other: Margin-Based Radiotherapy planning
Sponsor: University of Arkansas
Not yet recruiting
https://ift.tt/2Jv9qDb
QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.
Intervention: Biological: YE-NEO-001
Sponsor: NantBioScience, Inc.
Not yet recruiting
https://ift.tt/2HFveWV
Type I Chiari Malformation Presenting in an Adult
Description
Type I Chiari malformations (CMs) is an acquired or congenital disorder characterised by the presence of the cerebellar tonsils at 5 mm or below of the spinal canal, which can result in abnormal cerebrospinal fluid flow and produce headaches, syrinx or hydrocephalus. CMs are still considered an uncommon disease with a prevalence in the USA of less than 1%.1 2 We present a 44-year-old man with no medical history who presented to the emergency department complaining of nausea, vomiting, vertigo and a 2-day history of headaches exacerbated with Valsalva manoeuvres. He was initially admitted with a working diagnosis of ischaemic stroke and underwent a CT scan of the brain, which was unremarkable. Further work-up with brain MRI disclosed incidental cerebellar herniation 6.5 mm below the foramen magnum (figure 1) and no abnormalities in spinal canal MRIs. The patient was treated symptomatically with oral...
https://ift.tt/2JCSKFP
Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer
Non-bacterial thrombotic endocarditis (NBTE) is a well-described phenomenon associated with malignancies due to hypercoaguable state. In the setting of pancreatic cancer, NBTE is more commonly diagnosed postmortem. We describe a case of a man who was diagnosed with pancreatic carcinoma after incidental finding of NBTE. Imaging incidentally revealed multiple strokes, bilateral renal and splenic infarcts, while subsequent workup for cardioembolic source demonstrated a 1.1x0.7 cm mitral valve vegetation. As multiple blood cultures were sterile and patient lacked clinical signs of infection, an underlying malignancy was suspected. CT abdomen demonstrated a dilated pancreatic duct, MRI showed a 2.8x2.2 cm pancreatic head mass. Endoscopic biopsy of the mass revealed pancreatic adenocarcinoma. Other than NBTE, there were no other clinical or laboratory findings to clearly suggest pancreatic cancer. Thus, incidental discovery of this mitral valve vegetation led to the diagnosis of pancreatic malignancy.
https://ift.tt/2MiCXOe
Herpes zoster with cutaneous dissemination: a rare presentation of an uncommon pathology in children
Herpes zoster, caused by varicella zoster virus (VZV) reactivation, affects mainly the adult population, although it can occur in children. This happens when primary infection (varicella) has occurred at a very young age or in immunocompromised patients. Complications are rare in healthy individuals. They include VZV cutaneous dissemination, which affects 2%–10% of immunocompromised patients.
We present a previously healthy child, with history of varicella during her first month of life, which presented at age 8 with a severe case of herpes zoster, complicated with cutaneous dissemination. Immunity study was unremarkable. Causes, management and follow-up are discussed.
https://ift.tt/2JFxv6r
Central nervous system blast crisis of chronic myeloid leukaemia misdiagnosed as tubercular meningitis
Chronic Myeloid Leukaemia (CML) presenting with isolated Central Nervous System (CNS) blast crisis is an uncommon entity. A 22-year-old man, diagnosed with chronic phase CML in 2011 and was in haematological and cytogenetic remission until July 2016, had acute onset headache and vomiting with meningeal signs and was admitted elsewhere, investigated by brain imaging and cerebrospinal fluid (CSF) analysis and suspected to have tubercular meningitis, for which steroids and antitubercular medications were started. The patient's sensorium further deteriorated, and Ventriculoperitoneal shunt surgery was done for hydrocephalus by a neurosurgeon. After 2 months of the illness, he was admitted to our hospital with a persistent headache, vomiting and altered sensorium. CSF for cytospin confirmed myeloid blasts. He was still in haematological remission. So, a diagnosis of isolated CNS blast crisis was made. The patient was started on triple intrathecal chemotherapy and cranial radiotherapy. He had improvement with treatment and is still in remission.
https://ift.tt/2Mk9vYf
A Narrative Review of Adherence to Subarachnoid Hemorrhage Guidelines
Over the past 2 decades, a large number of guidelines for aneurysmal subarachnoid hemorrhage (aSAH) management have been proposed. The primary aim of these "evidence-based" guidelines is to improve the care of aSAH patients by summarizing and making current knowledge readily available to clinicians. However, an investigation into aSAH guidelines, their changes along time and their successful translation into clinical practice is still lacking. We performed a literature search of historical events and subarachnoid hemorrhage guidelines using the Entrez PubMed NIH, Embase, and Cochrane databases for articles published up to November of 2016. Data were summarized for guidelines on aSAH management and cross-sectional studies of their application. A total of 11 guidelines and 10 cross-sectional studies on aSAH management were analyzed. The use of nimodipine for the treatment of SAH is the only recommendation that remained consistent across guidelines over time (r=0.82; Phttps://ift.tt/2l5FVcu
General Anesthesia and Young Brain: What is New?
https://ift.tt/2l2XF8n
Epidural Blood Patch in Children Under Anesthesia: Is There an Indication for Neuromonitoring?
No abstract availablehttps://ift.tt/2t0oDBi
Endovascular Treatment of Acute Ischemic Stroke Under General Anesthesia: Predictors of Good Outcome
Background: The choice of anesthetic technique, general anesthesia (GA) versus Monitored Anesthesia Care, may impact the outcome of patients undergoing endovascular treatment of acute ischemic stroke (AIS). The aim of this study was to identify the factors associated with good discharge outcome in patients receiving GA for AIS. Materials and Methods: Electronic medical records of patients above 18 years old who underwent endovascular treatment of AIS under GA at a Comprehensive Stroke Center from 2010 to 2014 were reviewed. Good outcome was defined as discharge modified Rankin Score 0 to 2 and poor outcome as modified Rankin Score 3 to 6; logistic regression analysis was performed to examine the association between the clinical characteristics and the outcome. Results: In total, 88 patients (56 males), aged 63±15 years with median National Institute of Health Stroke Scale (NIHSS) score 16 (range, 4 to 38) were included. Nineteen (22%) patients had good outcome and 78 (88%) had systolic blood pressure below the guideline recommended 140 mm Hg under GA. After adjusting for age and NIHSS score, the independent predictors of good discharge outcomes were higher maximum end-tidal carbon dioxide (odds ratio [OR], 1.14; confidence interval [CI], 1.02-1.28; P=0.02) and extubation after endovascular treatment (OR, 26.31; CI, 4.80-144.12; Phttps://ift.tt/2l2rPZA
Scheduled Intravenous Acetaminophen Improves Patient Satisfaction With Postcraniotomy Pain Management: A Prospective, Randomized, Placebo-controlled, Double-blind Study
Background: Postcraniotomy pain can be difficult to manage with opioids due to opioid-related side effects, including drowsiness, nausea/vomiting, confusion, and pupillary changes, potentially masking the signs of postoperative neurological deterioration. Intravenous (IV) acetaminophen, a nonopioid analgesic, has been reported to have opioid-sparing effects after abdominal and orthopedic surgeries. This study investigates whether IV acetaminophen has similar effects after craniotomy. Materials and Methods: In this prospective, randomized, placebo-controlled, double-blind clinical trial, 100 adult patients scheduled to undergo supratentorial craniotomy for excision of a brain mass were randomized to receive either IV acetaminophen or placebo preincision and then every 6 hours for a total of 24 hours after surgery. Total 24-hour opioid consumption, pain scores, satisfaction with overall pain management, time to meet postanesthesia care unit discharge criteria, and incidence of opioid-related side effects were compared. Results: There was no difference in the 24-hour postoperative opioid consumption in morphine equivalents between the IV acetaminophen group (median, 11 mg; n=45) and the placebo group (median, 10.1 mg; n=41). No statistically significant difference of visual analog scale pain score was observed between 2 treatment groups. Patient satisfaction with overall postoperative pain management was significantly higher in the IV acetaminophen group than the placebo group on a 1 to 10 scale (8.1±0.4 vs. 6.9±0.4; P=0.03). There was no significant difference in secondary outcomes, including the incidence of opioid-related side effects. Conclusions: IV acetaminophen, as adjunctive therapy for craniotomy procedures, did not show an opioid-sparing effect in patients for the 24 hours after craniotomy; however, it was associated with improved patient satisfaction regarding overall pain control.https://ift.tt/2l2rAxE
Ventilation With High or Low Tidal Volume With PEEP Does Not Influence Lung Function After Spinal Surgery in Prone Position: A Randomized Controlled Trial
Background: Spinal surgery in the prone position is accompanied by increased intrathoracic pressure and decreased respiratory compliance. This study investigated whether intraoperative lung protective mechanical ventilation improved lung function evaluated with pulmonary function tests in patients at risk of postoperative pulmonary complications (PPCs) after major spinal surgery in the prone position. Methods: Seventy-eight patients at potential risk of PPCs were randomly assigned to the protective group (tidal volume; 6 mL/kg predicted body weight, 6 cm H2O positive end-expiratory pressure with recruitment maneuvers) or the conventional group (10 mL/kg predicted body weight, no positive end-expiratory pressure). The primary efficacy variables were assessed by pulmonary function tests, performed before surgery, and 3 and 5 days afterward. Results: Postoperative forced vital capacity (2.17±0.1 L vs. 1.91±0.1 L, P=0.213) and forced expiratory volume in 1 second (1.73±0.08 L vs. 1.59±0.08 L, P=0.603) at postoperative day (POD) 3 in the protective and conventional groups, respectively, were similar. Trends of a postoperative decrease in forced vital capacity (P=0.586) and forced expiratory volume in 1 second (P=0.855) were similar between the groups. Perioperative blood-gas analysis variables were comparable between the groups. Patients in the protective and conventional groups showed similar rates of clinically significant PPCs (8% vs. 10%, P>0.999). Conclusions: In patients at potential risk of developing PPCs undergoing major spinal surgery, we did not find evidence indicating any difference between the lung protective and conventional ventilation in postoperative pulmonary function and oxygenation.https://ift.tt/2l1kVDM
Feasibility of Protective Ventilation During Elective Supratentorial Neurosurgery: A Randomized, Crossover, Clinical Trial
Background: Traditional ventilation approaches, providing high tidal volumes (Vt), produce excessive alveolar distention and lung injury. Protective ventilation, employing lower Vt and positive end-expiratory pressure (PEEP), is an attractive alternative also for neuroanesthesia, when prolonged mechanical ventilation is needed. Nevertheless, protective ventilation during intracranial surgery may exert dangerous effects on intracranial pressure (ICP). We tested the feasibility of a protective ventilation strategy in neurosurgery. Materials and Methods: Our monocentric, double-blind, 1:1 randomized, 2×2 crossover study aimed at studying the effect size and variability of ICP in patients undergoing elective supratentorial brain tumor removal and alternatively ventilated with Vt 9 mL/kg—PEEP 0 mm Hg and Vt 7 mL/kg—PEEP 5 mm Hg. Respiratory rate was adjusted to maintain comparable end-tidal carbon dioxide between ventilation modes. ICP was measured through a subdural catheter inserted before dural opening. Results: Forty patients were enrolled; 8 (15%) were excluded after enrollment. ICP did not differ between traditional and protective ventilation (11.28±5.37, 11 [7 to 14.5] vs. 11.90±5.86, 11 [8 to 15] mm Hg; P=0.541). End-tidal carbon dioxide (28.91±2.28, 29 [28 to 30] vs. 28.00±2.17, 28 [27 to 29] mm Hg; Phttps://ift.tt/2l1kLMG
Epidural Injection of Platelet Rich Plasma for Postlumbar Puncture Headaches
No abstract availablehttps://ift.tt/2t1IrnW
Trends and Outcomes of Early Versus Late Percutaneous Endoscopic Gastrostomy Placement in Patients With Traumatic Brain Injury: Nationwide Population-based Study
Background: Oral intake for traumatic brain injury (TBI) patients is often not an option because of facial trauma, swallowing dysfunctions, altered consciousness, etc. These patients often require percutaneous endoscopic gastrostomy (PEG) placement for nutrition support. To date, there is lack of studies examining the relationship between the timing of PEG placement and patient outcome in the TBI group. Methods: We conducted a population-based study in a retrospective cohort of TBI patients undergoing PEG, using the national inpatient sample for years 2011 to 2013. Results: A total of 96,625 patients were identified for TBI and 3343 of those patients received PEG. TBI patients who undergo an early or late PEG placement had a higher rate of in-hospital mortality, when compared with patients with a standard timing of PEG placement. Late PEG was preferably placed in patients with higher Charlson index and trauma-related comorbidities, and these patients had a higher incidence of complications, that is, sepsis, urinary tract infection, acute respiratory distress syndrome/pneumonia, and deep vein thrombosis/pulmonary embolism. When stratified by mortality-risk groups, early PEG was associated with higher rates of in-hospital mortality while standard PEG was associated with best mortality outcomes in low–mortality-risk group and moderate–mortality-risk group. Conclusions: The results of this study suggest that if a PEG placement is indicated for a TBI patient, a standard (7 to 14 d) timing may be associated with better patient outcomes. However, secondary to limitations associated with the use of administrative databases, further prospective studies are needed to establish clear guidelines regarding the optimal timing of placing PEG in TBI patients.https://ift.tt/2l5XucH
A Pediatric Case With Takotsubo Cardiomyopathy and Neurogenic Pulmonary Edema Due to an Epidural Hemorrhage
No abstract availablehttps://ift.tt/2t1Id04
Intraoperative Neurological Monitoring With Evoked Potentials During Carotid Endarterectomy Versus Cooperative Patients Under General Anesthesia Technique: A Retrospective Study
Introduction: The best technique to evaluate contralateral carotid flow during carotid endarterectomy (CEA) is still debated; an accurate detection of efficient contralateral blood flow can avoid unnecessary shunt placement and its complications. The aim of this retrospective observational study was to evaluate and compare the safety and efficacy of general anesthesia with motor-evoked potential and somatosensory-evoked potentials (mSSEP and tcMEP) versus cooperative patients under general anesthesia (CPGA) technique for CEA. Primary outcome was the rate of technical failure. The procedural time and shunt incidence between the 2 neuromonitoring strategies were also analyzed. Patients and Methods: A total of 331 patients who consecutively underwent CEA were included (100 patients in the CPGA group and 231 in the mSSEP+tcMEP group). The anesthesia technique was customized according to the cerebral monitoring needs. Comparison between groups was performed along with risk analysis. Results: Electrophysiological monitoring seems to be a safe and effective strategy of neuromonitoring during CEA. Compared with the CPGA technique, it ensures fewer technical failures, reduces surgical and anesthesiological time and, moreover, it may reduce shunt risk/incidence. The incidence of shunt between the CPGA group and mSSEP+tcMEP was statistically different (CPGA 12%, mSSEP+tcMEP 5.2%; P=0.02), and the relative risk reduction in the mSSEP+tcMEP group, compared with the CPGA group, was 0.57. Conclusions: mSSEP and tcMEP neuromonitoring was associated with less technical failure and procedural time than asleep-awake-asleep strategy. The evoked potential neuromonitoring may be an alternative technique to awake clinical assessment during CEA.https://ift.tt/2l7hZ8K
Life-threatening Tachyarrhythmia Following Intra-Arterial Milrinone for Cerebral Vasospasm
No abstract availablehttps://ift.tt/2t3lTmw
Effect of Albumin in Combination With Mannitol on Whole-blood Coagulation In Vitro Assessed by Thromboelastometry
Background: Albumin and mannitol may interfere with hemostasis, but their coinfluence is unclear. We aimed to determine the effects of albumin alone and in combination with mannitol or Ringer acetate (RAC) on hemostasis in crossover in vitro study. Materials and Methods: From citrated fresh whole blood withdrawn from 10 volunteers, we prepared 2.5, 5, 10, 15, and 20 vol% dilutions of 4% albumin (Alb group). Each sample was thereafter diluted by 15% mannitol (Alb/Man group) or RAC (Alb/RAC group) at a ratio of 9:1. Using thromboelastometry, FibTEM (fibrinogen ROTEM) and ExTEM (extrinsic ROTEM) tests were performed. Results: A 20 vol%, but not 2.5 to 15 vol% dilution of albumin caused a prolonged clot formation time, α-angle decrease, and maximum clot firmness (MCF) weakening compared with undiluted sample (Phttps://ift.tt/2l61RV6
Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Publication date: Available online 11 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Zala Jevnikar, Jörgen Östling, Elisabeth Ax, Jenny Calvén, Kristofer Thörn, Elisabeth Israelsson, Lisa Öberg, Akul Singhania, Laurie C.K. Lau, Susan J. Wilson, Jonathan A. Ward, Anoop Chauhan, Ana R. Sousa, Bertrand De Meulder, Matthew J. Loza, Frédéric Baribaud, Peter J. Sterk, Kian Fan Chung, Kai Sun, Yike Guo, Ian M. Adcock, Debbie Payne, Barbro Dahlen, Pascal Chanez, Dominick E. Shaw, Norbert Krug, Jens M. Hohlfeld, Thomas Sandström, Ratko Djukanovic, Anna James, Timothy S.C. Hinks, Peter H. Howarth, Outi Vaarala, Marleen van Geest, Henric K. Olsson
BackgroundAlthough several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthma is unclear.ObjectiveTo explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthma.MethodsAn IL-6TS gene signature, obtained from air-liquid interface (ALI) cultures of human bronchial epithelial cells stimulated with IL-6 and sIL-6R, was used to stratify lung epithelium transcriptomic data (U-BIOPRED cohorts) by hierarchical clustering. IL-6TS-specific protein markers were used to stratify sputum biomarker data (Wessex cohort). Molecular phenotyping was based on transcriptional profiling of epithelial brushings, pathway analysis and immunohistochemical analysis of bronchial biopsies.ResultsActivation of IL-6TS in ALI cultures reduced epithelial integrity and induced a specific gene signature enriched in genes associated with airway remodeling. The IL-6TS signature identified a subset of IL-6TS High asthma patients with increased epithelial expression of IL-6TS inducible genes in absence of systemic inflammation. The IL-6TS High subset had an overrepresentation of frequent exacerbators, blood eosinophilia, and submucosal infiltration of T cells and macrophages. In bronchial brushings, TLR pathway genes were up-regulated while the expression of tight junction genes was reduced. Sputum sIL-6R and IL-6 levels correlated with sputum markers of remodeling and innate immune activation, in particular YKL-40, MMP3, MIP-1β, IL-8 and IL-1β.ConclusionsLocal lung epithelial IL-6TS activation in absence of type 2 airway inflammation defines a novel subset of asthmatics and may drive airway inflammation and epithelial dysfunction in these patients.
Graphical abstract
Teaser
By cluster analysis of lung epithelium transcriptomics data using an IL-6 trans-signaling gene signature we demonstrate the presence of a poorly controlled asthma patient subset associated with airway inflammation, remodeling and compromised epithelial barrier function.https://ift.tt/2sXrhre
Genetic variation in the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway affects contact hypersensitivity responses
Source:Journal of Allergy and Clinical Immunology
Author(s): Julien M.D. Legrand, Edwige Roy, Batoul Baz, Pamela Mukhopadhyay, Ho Yi Wong, Ramesh Ram, Grant Morahan, Graeme Walker, Kiarash Khosrotehrani
https://ift.tt/2MiRWId
Effects of Matricaria Recutita (L.) in the Treatment of Oral Mucositis
Objective. The objective of this study was to review the effects of the Matricaria recutita (L.) in the treatment of oral mucositis. Methodology. The online search was performed in the period from June 2016 to April 2018 by means of databases LILACS (Latin American and Caribbean Center on Health Sciences Information), SciELO (Scientific Electronic Library Online), and MEDLINE (Medical Literature Analysis and Retrieval System Online). The consultation was restricted to the years 1991 to 2018 with the aim of elucidating the effects of Matricaria recutita in the treatment of oral mucositis. Results. The final sample consisted of 21 studies, of which 10 were developed in animals and 11 in humans, published from 1991 to 2017, with a total sample of 644 patients. The total number of patients treated with Matricaria included in 11 studies was 364, while in the control groups the total number was 280. In experimental studies, animal models used were rats and the sample size ranged between 36 and 105 animals submitted to the induction of oral mucositis, where 4 studies used an intraperitoneal injection of 5-fluorouracil, while 7 induced lesion in the mucosa. From the data collected, it should be noted that both studies with humans and with animals showed significant effects. In this way, there is strong evidence for the discussion on the therapy; however, it should be noted that more studies are developed in order to clarify the most appropriate protocol for the prevention and treatment of injuries. Conclusion. According to the results found in this study, Matricaria recutita appeared to be a promising alternative for the treatment of oral mucositis. However, due to the great variability in the various types of intervention, more controlled double-blind randomized clinical studies are necessary to ensure the best protocol for treating oral mucositis.
https://ift.tt/2t2tstJ
Digital Models as an Alternative to Plaster Casts in Assessment of Orthodontic Treatment Outcomes
Objective. This study aimed to compare the use of digital models and plaster casts in assessing the improvement in occlusion following orthodontic treatment. Materials and Methods. Digital models and plaster casts of 39 consecutive patients at pre- and posttreatment stages were obtained and assessed using the Peer Assessment Rating (PAR) index and the Index of Complexity and Treatment Need (ICON). PAR and ICON scores were compared at individual and group levels. Categorization of improvement level was compared using Kappa () statistics. Results. There was no significant difference in neither PAR scores (p > 0.05) nor ICON scores (p > 0.05) between digital and plaster cast assessments. The Intraclass Correlation Coefficient (ICC) values for changes in PAR and ICON scores were excellent (ICC > 0.80). Agreement of ratings of occlusal improvement level between digital and plaster model assessments was 0.83 () for PAR and 0.59 () for ICON, respectively. Conclusion. The study supported the use of digital models as an alternative to plaster casts when assessing changes in occlusion at the 'individual patient' level using ICON or PAR. However, it could not fully support digital models as an alternate to plaster casts at 'the group level' (as in the case of clinical audit/research).
https://ift.tt/2l2Gioj
Sclerotic Bone Metastasis in Pulmonary Adenocarcinoma
Pulmonary adenocarcinoma is one of the major types of lung cancers in which metastasis is very common and it accounts approximately to one-third of all primary pulmonary cancers. Although a minority of patients with lung cancer are asymptomatic, which gets usually detected in routine chest radiography, most of the patients present with some symptoms. Lung cancer metastasis may occur virtually in every organ system. Patients with non-small-cell lung cancer commonly have extrathoracic metastases to the adrenal glands, liver, brain, bones, and lymph nodes at presentation. Approximately one-third of patients with lung cancer will present with symptoms related to extrathoracic spread. Metastasis to the bone is not uncommon in lung cancer; however, osteoblastic bone metastasis is very rare. Here we present a 30-year-old female diagnosed to have pulmonary adenocarcinoma with multiple sclerotic bony lesions in the vertebra.
https://ift.tt/2LEL7PK
ACTH Gel in Resistant Focal Segmental Glomerulosclerosis after Kidney Transplantation
https://ift.tt/2l3948g
Risk factors and clinical course for liver steatosis or nonalcoholic steatohepatitis after living donor liver transplantation
https://ift.tt/2t29MGf
Contemporary considerations in concurrent endoscopic sinus surgery and rhinoplasty
https://ift.tt/2t1qxBL
Contemporary considerations in concurrent endoscopic sinus surgery and rhinoplasty
https://ift.tt/2t1qxBL
Improving Clinical Proficiency Using a 3-Dimensionally Printed and Patient-Specific Thoracic Spine Model as a Haptic Task Trainer
https://ift.tt/2sQxW7s
The impact of unplanned reoperations in head and neck cancer surgery on survival
Source:Oral Oncology, Volume 83
Author(s): Nayeon Choi, Song I Park, Hyeseung Kim, Insuk Sohn, Han-Sin Jeong
ObjectivesUnplanned reoperation causes physical and psychological stress in patients and it costs more in terms of medical, economic and social resource. The purpose of the study was to evaluate the incidence, risk factors and clinical significance of unplanned reoperation (any unscheduled surgery within 30 days from the initial surgery) in patients who had undergone head and neck cancer (HNC) surgery.Materials and methodsA total of 574 consecutive patients who had received surgery for HNC with or without flap reconstruction from 2010 to 2015 were analyzed. Clinical and biochemical characteristics, cause of unplanned reoperation, cancer subsites, and previous treatment history were compared between unplanned reoperation group (n = 60) and control group (n = 514). Multivariable analyses were performed to identify risk factors for unplanned reoperation. Clinical significance was evaluated by multivariable survival analyses using Cox proportional hazard model.ResultsOverall rate of unplanned reoperation was 10.5%. Flap complication (40.0%) was the most common cause, followed by infection (16.7%), necrosis (11.7%), and bleeding (8.3%). Higher N (N2) classification, long operation time and previous treatment before surgery were identified as risk factors for unplanned reoperation. Based on multivariable survival analyses, recurrence-free survival was significantly decreased in unplanned reoperation group (Hazard ratio = 1.85, 95% confidence interval [1.23–2.80]), but not overall survival.ConclusionUnplanned reoperation significantly decreased recurrence-free survival in patients with HNC surgery. Thus, careful surgical/ perioperative management is needed to reduce unplanned reoperation in HNC patients with advanced nodal disease, long operation time or previous treatment history.
https://ift.tt/2l2sSsr
MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma
Source:Oral Oncology, Volume 83
Author(s): Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Wittenborg Charabi, Henrik Ullum, Lena Specht, Ane Yde Schmidt, Finn Cilius Nielsen, Christian von Buchwald
BackgroundMicroRNAs (miRNAs) hold promise as diagnostic cancer biomarkers. Here we aimed to define the miRNome in oral squamous cell carcinoma (OSCC) and normal oral mucosa (NOM), and to identify and validate new diagnostic miRNAs and miRNA combinations in formalin-fixed paraffin-embedded (FFPE) tissue samples and plasma samples.MethodsWe performed next-generation miRNA sequencing in FFPE tissue samples of OSCC (n = 80) and NOM (n = 8). Our findings were validated by quantitative polymerase chain reaction (qPCR) analysis of OSCC (n = 195) and NOM (n = 103) FFPE tissue samples, and plasma samples from OSCC patients (n = 55) and healthy persons (n = 18).ResultsThe OSCC miRNome included 567 miRNAs, 66 of which were differentially expressed between OSCC and NOM. Using qPCR data, we constructed receiver operating curves to classify patients as NOM or OSCC based on miRNA combinations. The area under the curve was of 0.92 from FFPE tissue (miR-204-5p, miR-370, miR-1307, miR-193b-3p, and miR-144-5p), and 1.0 from plasma samples (miR-30a-5p and miR-769-5p). Model calibration and discrimination were evaluated using 10-fold cross-validation.ConclusionsAnalysis of the miRNome from many OSCC cases improves our knowledge of the importance of individual miRNAs and their predictive potential in OSCC. We successfully identified miRNA classifiers in FFPE OSCC tissue and plasma with a high discriminatory ability between OSCC and NOM. The proposed combination of miR-30a-5p and miR-769-5p in plasma from OSCC patients could serve as a minimal invasive biomarker for diagnosis and control of T-site recurrences.
https://ift.tt/2sWFoNu
Un nouveau cas d’éruption de type pityriasis rubra pilaire associée à l’inhibiteur de tyrosine kinase ponatinib
Publication date: Available online 11 June 2018
Source:Annales de Dermatologie et de Vénéréologie
Author(s): J. Krygier, G. Leemans, R. Forsyth, A. de Becker, J. Gutermuth, M. Grosber
IntroductionLe pityriasis rubra pilaire (PRP) est un syndrome cutané d'étiologie inconnue dont la plupart des cas sont sporadiques et acquis. Nous rapportons un cinquième cas d'éruption de type PRP associée au ponatinib, un inhibiteur de tyrosine kinase (ITK).ObservationUne femme de 60ans se présentait à la consultation de dermatologie pour une éruption érythémato-squameuse évoluant depuis 2 semaines. La patiente était également suivie en hématologie pour une récidive de leucémie lymphoblastique aiguë. Un traitement par ponatinib avait été débuté 6 semaines plus tôt. Malgré l'aspect peu spécifique de l'histologie cutanée, le diagnostic d'éruption de type PRP induit était posé face à l'image clinique caractéristique. Le traitement par corticoïdes locaux permettait la résolution de l'éruption.DiscussionLa littérature rapporte six cas d'éruption de type PRP associés à la prise d'ITK, dont quatre avec le ponatinib. L'éruption survient dans un délai variant de 2 semaines à 3 mois après le début du traitement. Les corticoïdes locaux prescrits ont donné des résultats mitigés. Une meilleure compréhension de la physiopathologie de ces éruptions associées aux ITK pourrait éclairer les mécanismes pathogéniques du PRP idiopathique.BackgroundPityriasis rubra pilaris (PRP) is a cutaneous syndrome of unknown origin. Most cases are sporadic and acquired. Herein we report a fifth case of PRP-like eruption associated with ponatinib, a tyrosine kinase inhibitor (TKI).Patients and methodsA 60-year-old woman presented at the dermatology department with an erythemato-squamous eruption present for 2weeks. The patient was also being treated in haematology for recurrence of acute lymphoblastic leukaemia. Treatment with ponatinib had been initiated 6weeks earlier. Despite the low specific cutaneous histology, a diagnosis of induced PRP-like eruption was made based on the characteristic clinical aspect. Treatment with local corticosteroids resolved the eruption.DiscussionThe literature contains 6 reported cases of PRP-like eruptions associated with TKI, including 4 with ponatinib. The eruption began from 2weeks to 2–3 months after treatment induction. Prescribed topical corticosteroids have yielded mixed results. A better understanding of the physiopathology of these eruptions associated with TKI could shed light on the pathogenic mechanisms in relation to idiopathic PRP.
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