Publication date: 15 February 2016
Source:Behavioural Brain Research, Volume 299
Author(s): Jenny R. Köppen, Sarah L. Stuebing, Megan L. Sieg, Ashley A. Blackwell, Philip A. Blankenship, Joseph L. Cheatwood, Douglas G. Wallace
Dementia of the Alzheimer's type (DAT) is a neurodegenerative disorder marked by loss of hippocampal cholinergic tone and significant memory impairments, specifically for memories acquired prior to disease onset. The nature of this relationship, however, remains debated. The current study used the string pulling task to evaluate the temporal effects of odor discrimination learning in animals with selective cholinergic lesions to determine the role of the septohippocampal cholinergic system in mnemonic function. Rats with 192-IgG-Saporin lesions to the medial septum had a higher number of correct responses in the reversal training when compared to sham rats, suggesting an inability to retrieve the previously learned discrimination; however, no temporal gradient was observed. Furthermore, there were no group differences when learning a novel odor discrimination, demonstrating the ability for all rats to form new memories. These results establish a role for the cholinergic medial septum projections in long-term memory retrieval. The current study provides a behavioral assessment technique to investigate factors that influence mnemonic deficits associated with rodent models of DAT.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1IHZryW
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
▼
2015
(1500)
-
▼
Δεκεμβρίου
(1450)
-
▼
Δεκ 03
(66)
- Pain management in head and neck cancer patients u...
- An approach to the diagnosis of spindle cell lesio...
- Sentinel lymph nodes for breast carcinoma: an upda...
- Issue Information
- The cancer genetics and pathology of male breast c...
- Markers of metastatic carcinoma of breast origin
- Phyllodes tumours of the breast: a consensus review
- Biomarker assessment and molecular testing for pro...
- E-cadherin immunohistochemistry in breast patholog...
- Pathological criteria and practical issues in papi...
- Breast cancer stem cells: are we ready to go from ...
- Annual Review Issue: Breast Pathology
- Ductal carcinoma in situ – update on risk assessme...
- Recommendations for excision following core needle...
- Alternative treatment of restless legs syndrome: a...
- Significant association between systolic and diast...
- Automated design of domain-specific custom instruc...
- Putting RNA to work: translating RNA fundamentals ...
- LCA-based indicators for recycling: a case study o...
- Full-wave multiconductor waveguide analysis and a ...
- Cholinergic deafferentation of the hippocampus cau...
- Cryopreserved arterial allograft vascular reconstr...
- Integration of trauma and rehabilitation services ...
- Pneumocephalus following thoracic trauma: a rare e...
- Routine multidisciplinary cerebrovascular meetings...
- Short-term outcomes of local infiltration anaesthe...
- Lixisenatide in Patients with Type 2 Diabetes and ...
- Pylephlebitis as a Complication of Diverticulitis
- Retraction: Ahimastos AA, Dart AM, Kingwell BA. An...
- Ending the HIV–AIDS Pandemic — Follow the Science
- Tenuous Tether
- Individual Responsibility and Community Solidarity...
- Back to Nature
- Cardiac Complications in Patients Undergoing Major...
- Tenuous Tether
- Cystine Crystals in Bone Marrow
- Intensive Supportive Care plus Immunosuppression i...
- Prenatal Factors in Cerebral Palsy
- Estimating the Long-Term Treatment Benefits of Sac...
- Lixisenatide in Patients with Type 2 Diabetes and ...
- Report from Paris
- Cytomegalovirus reactivation and its clinical impa...
- Preventing Foodborne Staphylococcal Disease – Hygi...
- Defenders of the image. Painted collectors’ cabine...
- Forest fire dynamics during the early and middle H...
- 'Most rare workmen': optical practitioners in earl...
- Recombinant Resilin-Based Bioelastomers for Regene...
- Periodic Nanoneedle and Buffer Zones Constructed o...
- Peripheral NMDA Receptors Mediate Antidromic Nerve...
- Information for Readers
- Instructions for Authors
- Developing Costimulatory Molecules for Immunothera...
- Table of Contents
- Editorial Board
- Allergen of the Month—Japanese Maple
- Bronchial thermoplasty: a review of the evidence
- The recurrently wheezing preschool child—benign or...
- Long-term omalizumab therapy for refractory chroni...
- Author Index to Volume 115, 2015
- Methicillin-Resistant Staphylococcus Aureus
- Methicillin-Resistant Staphylococcus Aureus in Sau...
- Cyclic vomiting syndrome
- Pharmaceutical care in the community pharmacies of...
- Sialolipoma of the superficial lobe of the parotid...
- Acute back pain: A survey of primary health care p...
- Trivial head injury or not?
-
▼
Δεκ 03
(66)
-
▼
Δεκεμβρίου
(1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου