Effect of ticlopidine on acute and subacute models of inflammation in male wistar rats: an experimental study

2015-12-09T00-52-20Z
Source: International Journal of Research in Medical Sciences
Netravathi Basavaraj Angadi, Shrishail V. Hiremath, Vijaylakshmi V. Suranagi.
Background: Atherosclerosis and its complications remains the major cause of death and premature disability. Atherogenesis involves elements of inflammation, a process that now provides a unifying theme in the pathogenesis of the disease. Anti-platelet drugs are currently used in the treatment of atherosclerosis and its complications. Our study evaluated the influence of ticlopidine on acute and sub-acute models of inflammation in male Wistar rats. Methods: Male wistar rats (150-200g) were divided into three groups i.e. control, Aspirin and ticlopidine (n=6 animals in each group). The effect of ticlopidine, administered orally, on inflammation was studied using acute (carrageenan induced rat paw edema) and sub-acute (cotton pellet granuloma and histopathological examination of grass piths) models. Experiment was conducted according to the Committee for the Purpose of Control and Supervision on Experiments on Animals (CPCSEA) guidelines. Analysis was done using one way ANOVA followed by Post Hoc Test of Dunnets. P


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