[Prognostic variability in atypical meningioma with complete resection. Proposed treatment algorithm].

[Prognostic variability in atypical meningioma with complete resection. Proposed treatment algorithm].

Neurocirugia (Astur). 2015 Dec 10;

Authors: Real-Peña L, Talamantes Escribá F, Quilis-Quesada V, González-Darder JM

Abstract
OBJECTIVE: The authors attempt to show how the current prognostic factors that try to assess the risk of recurrence of atypical meningiomas are insufficient to predict the future of this disease.
MATERIALS AND METHOD: Using data obtained from hospital databases, a sample of 27 patients was obtained with pathological diagnosis of atypical meningioma, and who had a minimum follow-up time of 6months after diagnosis. Later prognostic factors (age <50years, male gender, bone involvement, peri-lesional swelling, tumour volume, location, Ki67/MIB-1) were evaluated after the stratification of patients undergoing complete resection in recurrencies and non-recurrencies. Univariate analysis was performed using Mann-Whitney test, χ(2) homogeneity test/Fisher exact test. Finally, multivariate analysis was performed using binary logistic regression to obtain the values for R(2) Nagelkerke and the Hosmer-Lemeshow to evaluate the goodness of fit.
RESULTS: The uni- and multivariate analysis showed no statistically significant differences between recurrent and non-recurrent subgroups of patients undergoing complete resection. It is noted in the results that for each year of age above 50years, the risk of recurrence is decreased by 5.8%.
CONCLUSIONS: Although current prognostic factors may show an increased risk of recurrence once patients are stratified by the two most important factors (pathology and extent of resection), those factors are insufficient to predict the ultimate outcome of patients affected by this pathology.

PMID: 26687847 [PubMed - as supplied by publisher]

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