[Treatment Strategy for Gastric Carcinoma with Lymphoid Stroma].

[Treatment Strategy for Gastric Carcinoma with Lymphoid Stroma].

Gan To Kagaku Ryoho. 2015 Nov;42(12):2021-3

Authors: Kobayashi R, Takiguchi N, Nabeya Y, Ikeda A, Souda H, Kainuma O, Tonooka T, Imanishi S, Arimitsu H, Chibana T, Ishige F, Sasaki K, Yamamoto H

Abstract
Gastric carcinoma with lymphoid stroma(GCLS)is a histological type with severe lymphocytic infiltration. GCLS is very rare and few cases have been reported. We examined the clinical features, problems of preoperative diagnosis, and treatment of 14 cases(1.8%)that were diagnosed as GCLS out of 790 gastric cancers surgically resected in our hospital. The mean age was 69 years. Six, 8, and 0 cases were located in the upper, middle, and lower fields of the stomach, respectively, and 8, 1, 4, and 1 cases were macroscopically 0-Ⅱc, 0-Ⅰ, type 2, and type 3, respectively. The depth of invasion was M, SM1, SM2, MP, and SS in 0, 0, 9, 3, and 2 cases, respectively. There were 12 cases(86%)with infection by Epstein-Barr virus, and just 1 case with lymph node metastasis. All cases have had no evidence of recurrence. There were no cases that were diagnosed as GCLS before surgery. GCLS is recognized as having a more favorable prognosis compared with other types of gastric carcinoma, so an aggressive surgery might achieve good outcomes. However, preoperative diagnosis is very difficult and there is a compelling need for new techniques or criteria for diagnosis of GCLS.

PMID: 26805251 [PubMed - in process]

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