Histopathology of NET: current concepts and new developments

Publication date: Available online 26 February 2016
Source:Best Practice & Research Clinical Endocrinology & Metabolism
Author(s): Anja M. Schmitt, Annika Blank, Ilaria Marinoni, Paul Komminoth, Aurel Perren
The diagnosis of neuroendocrine tumours is based on their histopathologic appearance and immunohistochemical profile. With the WHO 2010 classification formal staging and grading was introduced for gastro-entero-pancreatic NET, however, the nomenclature for lung neuroendocrine tumors still relies on the carcinoid term.In this review we also focus on the situation of neuroendocrine carcinoma of unknown primary, tissue biomarkers and actual controversies in the histopathology of NEN.



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