MicroRNA miR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10

Publication date: Available online 1 February 2016
Source:Clinical Immunology
Author(s): Xiao-Fang Liu, Run-Qi Wang, Bo Hu, Meng-Chuan Luo, Qiu-Ming Zeng, Hao Zhou, Kun Huang, Xiao-Hua Dong, Yue-Bei Luo, Zhao-Hui Luo, Huan Yang
MiR-15a is likely to be associated with autoimmunity. Here, we aimed to examine the expression of miR-15 cluster in PBMCs from myasthenia gravis (MG) patients and investigate the potential roles of miR-15a in MG. We found that the expression of all miR-15 cluster was decreased in MG, furthermore, miR-15a levels in ocular MG (oMG) were much lower, while CXCL10 production was increased in MG. We display that CXCL10 was a functional target gene of miR-15a in MG. Increasing miR-15a expression could reduce CXCL10 expression and alleviate the abnormal T cells activation in immune response, while decreasing miR-15a expression could activate immune response abnormally. Moreover, miR-15a expression was significantly decreased after stimulation, and prednisone treatment could upregulate miR-15a expression in steroid-responsive MG patients. Take together, our data suggest that decreased miR-15a expression facilitates proinflammatory cytokines production and contributes to immune response at least in part via regulating CXCL10 expression in MG.

Graphical abstract

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1SBSW8t
via IFTTT