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Quercetin modulated erythrocyte membrane sodium hydrogen exchanger during human aging: correlation with ATPase's.
Arch Physiol Biochem. 2016 Feb 2;:1-26
Authors: Kumar P, Chand S, Maurya PK
Abstract
CONTENT: Quercetin uptake by erythrocytes is rapid. The sodium hydrogen exchanger (NHE) is a secondary active transporter, regulating intracellular pH, Na(+) concentration, and cell volume.
OBJECTIVE: The aim of present study was to investigate NHE as a function of human age and effect of quercetin on its activity. The NHE activity was correlated with erythrocytes ATPases.
MATERIALS AND METHODS: We analyzed normal, healthy subjects of both sexes (20-82 years). NHE activity was estimated in terms of amiloride-sensitive H+-efflux from acid loaded cells.
RESULTS: A significant age dependent increase in NHE activity was observed during aging in humans. Concentration (10(-3)M to 10(-8)M) dependent in vitro treatment with quercetin causes inhibition of NHE activity. The Na(+)/K(+) -ATPase (r = 0.8882) and Ca(2+) -ATPase (r = 0.9540) activities positively correlated with it.
DISCUSSION AND CONCLUSION: The present data show an additional mechanism where dietary flavonoids may exerts beneficial effect during aging.
PMID: 26835548 [PubMed - as supplied by publisher]
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