Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes.

Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes.

J Clin Endocrinol Metab. 2016 Apr 26;:jc20161437

Authors: Furst JR, Bandeira LC, Fan WW, Agarwal S, Nishiyama KK, McMahon DJ, Dworakowski E, Jiang H, Silverberg SJ, Rubin MR

Abstract
CONTEXT: Skeletal deterioration, leading to an increased risk of fracture, is a known complication of type 2 diabetes mellitus (T2D). Yet plausible mechanisms to account for skeletal fragility in T2D have not been clearly established.
OBJECTIVE: To determine whether bone material properties, as measured by reference point indentation, and advanced glycation endproducts (AGEs), as determined by skin autofluorescence (SAF), are related in patients with T2D.
DESIGN: Cross-sectional study.
SETTING: Tertiary medical center.
PATIENTS: Sixteen postmenopausal women with T2D and 19 matched controls.
MAIN OUTCOME MEASURES: Bone material strength index (BMSi) by in vivo reference point indentation, AGE accumulation by SAF and circulating bone turnover markers.
RESULTS: BMSi was reduced by 9.2% in T2D (p=0.02) and was inversely associated with duration of T2D (r= -0.68, p= 0.004). Increased SAF was associated with reduced BMSi (r= -0.65, p=0.006) and lower bone formation marker procollagen type 1 amino-terminal propeptide (r= -0.63, p=0.01) in T2D, while no associations were seen in controls. SAF accounted for 26% of the age-adjusted variance in BMSi in T2D (p=0.03).
CONCLUSIONS: Bone material properties are impaired in postmenopausal women with T2D as determined by reference point indentation. The results suggest a role for the accumulation of AGEs to account for inferior BMSi in T2D.

PMID: 27115060 [PubMed - as supplied by publisher]

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