Source:Vaccine
Author(s): Leif G. Hanitsch, Madlen Löbel, Jan Florian Mieves, Sandra Bauer, Nina Babel, Brunhilde Schweiger, Kirsten Wittke, Patricia Grabowski, Hans-Dieter Volk, Carmen Scheibenbogen
BackgroundImmunization against seasonal influenza with inactivated vaccine is recommended for patients with common variable immunodeficiency (CVID). However, humoral vaccine response in CVID patients is frequently impaired and current knowledge on T cell vaccine response in CVID and other patients with antibody deficiency is poor.ObjectiveIn the present study, we comparatively analyzed the antibody and T cellular immune response of patients with CVID and unclassified antibody deficiency to influenza vaccination in the season 2013/2014.MethodsEight patients with CVID, 8 patients with unclassified antibody deficiency and 9 healthy controls were vaccinated with a single dose of non-adjuvanted seasonal influenza vaccine. Before and 3 weeks after the vaccination antibody titers against the strains A/California/7/2009, A/Texas/50/2012, and B/Massachusetts/02/2012 included in the vaccine were measured by hemagglutination inhibition testing. Additionally, vaccine-specific T cell cytokine response was determined by stimulation with the complete vaccine in vitro.ResultsWhereas all healthy controls responded to vaccination with serum antibody titers, only 1/8 CVID patients and 4/8 patients with unclassified antibody deficiency showed a response against at least 1 of the 3 vaccine strains. However, 7/8 of the CVID and 6/8 of the patients with unclassified antibody deficiency had similar frequencies of vaccine-induced IFN-γ, TNF-α and IL-2 producing CD40L+ T cells as the control group.ConclusionOur data suggest that most CVID and unclassified antibody deficiency patients benefit from seasonal influenza vaccination by mounting a cellular response.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/237GuVi
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου