Hydraphiles Enhance Antimicrobial Potency Against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis

Publication date: Available online 27 April 2016
Source:Bioorganic & Medicinal Chemistry
Author(s): Mohit B. Patel, Evan C. Garrad, Ariel Stavri, Michael R. Gokel, Saeedeh Negin, Joseph W. Meisel, Zachary Cusumano, George W. Gokel
Hydraphiles are synthetic amphiphiles that form ion-conducting pores in liposomal membranes. These pores exhibit open-close behavior when studied by planar bilayer conductance techniques. In previous work, we showed that when co-administered with various antibiotics to the DH5α strain of E. coli, they enhanced the drug's potency. We report here potency enhancements at low concentrations of hydraphiles for the structurally and mechanistically unrelated antibiotics erythromycin, kanamycin, rifampicin, and tetracycline against Gram negative E. coli (DH5α and K-12) and Pseudomonas aeruginosa, as well as Gram positive Bacillus subtilis. Earlier work suggested that potency increases correlated to ion transport function. The data presented here comport with the function hydraphiles to enhance membrane permeability in addition to, or instead of, their known function as ion conductors.

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