Ligand- and Base-Free Access to Diverse Biaryls by the Reductive Coupling of Diaryliodonium Salts

Abstract

A ligand- and base-free, Pd-catalyzed protocol to access a wide range of symmetrical and unsymmetrical biaryls from stable diaryliodonium salts was developed. The reaction involved the use of an effective and recyclable Pd/polyethylene glycol-400 catalyst system to harness the aryl moieties of two diaryliodonium salts; the ensuing biaryls may be utilized to synthesize an array of useful compounds, including 5-aryluracils, carbazoles, chromenones, fluorenones, phenathridines, and boscalid analogues.

The ligand- and base-free, Pd-catalyzed synthesis of useful symmetrical and unsymmetrical biaryls in high yields from stable diaryliodonium salts is developed. The reaction is catalyzed by a recyclable Pd/polyethylene glycol-400 (PEG-400) system and proceeds under mild reaction conditions to produce biaryls that can be utilized to synthesize an array of natural and druglike compounds.

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