miR-1207-5p suppresses lung cancer growth and metastasis by targeting CSF1.

miR-1207-5p suppresses lung cancer growth and metastasis by targeting CSF1.

Oncotarget. 2016 Apr 13;

Authors: Dang W, Qin Z, Fan S, Wen Q, Lu Y, Wang J, Zhang X, Wei L, He W, Ye Q, Yan Q, Li G, Ma J

Abstract
We previously reported that miR-1207-5p can inhibit epithelial-mesenchymal transition (EMT) induced by growth factors such as EGF and TGF-β, but the exact mechanism is unclear. Here we identified that Colony stimulating factor 1 (CSF1) is a target gene of miR-1207-5p. CSF1 controls the production, differentiation and function of macrophage and promotes the release of proinflammatory chemokines. We showed that miR-1207-5p inhibited lung cancer cell A549 proliferation, migration and invasion in vitro, and suppressed the STAT3 and AKT signalings. miR-1207-5p overexpression can increase HUVEC angiogenesis, and can modulate the M2 phenotype of macrophage. miR-1207-5p also significantly inhibited A549 cells metastasis in a nude mouse xenograft model. miR-1207-5p and CSF1 expression levels and their relationship with lung cancer survival and metastasis status were assayed by means of a lung cancer tissue microarray. Macrophage is an essential part of the tumor microenvironment, thus the miR-1207-5p-CSF1 axis maybe a new regulator of lung cancer development through modulating the tumor microenvironment.

PMID: 27107415 [PubMed - as supplied by publisher]

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