XPA: A key scaffold for human nucleotide excision repair

Publication date: Available online 20 May 2016
Source:DNA Repair
Author(s): Norie Sugitani, Robert M. Sivley, Kelly E. Perry, John A. Capra, Walter J. Chazin
Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.



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