Extracellular matrix for vocal fold lamina propria replacement: A review.
Tissue Eng Part B Rev. 2016 Jun 17;
Authors: Wrona EA, Peng R, Amin MR, Branski R, Freytes DO
Abstract
The vocal folds (VFs) are exposed to a number of injurious stimuli that frequently lead to aberrant structural alterations and altered biomechanical properties that clinically manifest as voice disorders. Therapies to restore both structure and function of this delicate tissue are ideal. However, such methods have not been adequately developed. Our group and others hypothesize that tissue engineering and regenerative medicine approaches, previously described for other tissue systems, hold significant promise for the VFs. In the current review, we explore the concept of tissue engineering as it relates to the VFs as well as recent studies employing both naturally- and synthetically-derived biomaterials, including those from laryngeal and non-laryngeal sources, in combination with stem cells for a tissue-engineered approach to VF repair.
PMID: 27316784 [PubMed - as supplied by publisher]
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