Publication date: 8 June 2016
Source:Vaccine, Volume 34, Issue 27
Author(s): Delphine Knittel, Adeline Gadzinski, Stéphane Hua, Jordan Denizeau, Alexandra Savatier, Philippe de la Rochère, Jean-Claude Boulain, Sebastian Amigorena, Eliane Piaggio, Christine Sedlik, Michel Léonetti
Heparan sulfates (HS) are carbohydrate moieties of HS proteoglycans (HSPGs). They often represent alternative attachment points for proteins or microorganisms targeting receptors. HSPGs, which are ubiquitously expressed, thereby participate in numerous biological processes. We previously showed that MHC class II-restricted antigen presentation is increased when antigens are coupled to HS ligands, suggesting that HSPGs might contribute to adaptive immune responses. Here, we examined if HSPG targeting influences other aspects of immune responses. We found that coupling of an HS ligand to the antigen increases antigen presentation to CD4+ and CD8+ T-cells after antigen targeting to membrane immunoglobulins or to MHC-II molecules. Moreover, this increased stimulating capacity correlates with an enhanced CD8+ immune response in mice. Last, animals control more effectively the growth of Ova-expressing tumour cells when they are immunized with an Ova construct targeting HSPGs and MHC-II molecules. Our results indicate that ubiquitous molecules can influence both MHC class I- and MHC class II-restricted antigen presentation and behave as co-receptors during T-cell stimulation. Moreover, they suggest that tumour-antigens endowed with the ability to target both HSPGs and MHC-II molecules could be of value to increase CD8+ immune response and control tumour-growth, opening new perspectives for the design of highly immunogenic protein-based vaccines.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1U1i3BF
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
▼
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
-
▼
Ιουνίου
(1110)
-
▼
Ιουν 04
(49)
- A Protocol for Management of the Hairs Problem in ...
- Congenital Hypertonia of the Temporalis Leading to...
- The utility of p16 immunostaining in fine needle a...
- Real-World Effectiveness and Safety of a Live-Atte...
- Multiple efficacy studies of an adenovirus-vectore...
- Control of Ixodes ricinus and Dermacentor reticula...
- Editorial Board/Aims and Scope
- A population profile of measles susceptibility in ...
- Emergence of antigenic variants within serotype A ...
- Effect of high and low levels of maternally derive...
- Impact of enterovirus and other enteric pathogens ...
- Vaccination against H5 avian influenza virus induc...
- Immune effects of the vaccine of live attenuated A...
- Heparan sulfates targeting increases MHC class I- ...
- CRACC-targeting Fc-fusion protein induces activati...
- Immunogenicity and safety of high-dose trivalent i...
- Phase I, randomized, observer-blind, placebo-contr...
- Characterization of serum antibodies from women im...
- Up-regulation of BSEP and MRP2 by Calculus Bovis a...
- Amelioration of testosterone induced benign prosta...
- Rheumatoid arthritis onset in postmenopausal women...
- Neonatal overfeeding induces early decline of the ...
- Upregulation of long noncoding RNA LOC100507661 pr...
- Oxidative stress and the subcellular localization ...
- Estrogen receptor profiling and activity in cardia...
- Up-regulation of Hsp27 by ERα/Sp1 facilitates prol...
- Urinary metabolomic profiling in mice with diet-in...
- An analogue of atrial natriuretic peptide (C-ANP4-...
- Benzyl butyl phthalate induces epigenetic stress t...
- Fibronectin-1 expression is increased in aggressiv...
- Novel dual agonist peptide analogues derived from ...
- Expression analysis and localization of wt1, ad4bp...
- Laparoscopy-assisted distal gastrectomy for early ...
- Value Based Care and Patient-Centered Care: Diverg...
- Genome-wide association of familial prostate cance...
- Stable isotope on the evaluation of water quality ...
- Microbial disinfection of water with endotoxin deg...
- An improved biofilter to control the dissolved org...
- Combination of antibiotics suppressed the increase...
- Cultivating Chlorella vulgaris and Scenedesmus qua...
- Insight into visible light-driven photocatalytic d...
- Impact of molybdenum nanoparticles on survival, ac...
- Bioavailability of pollutants sets risk of exposur...
- Surfactant enhanced pyrene degradation in the rhiz...
- Exploitation of subabul stem lignin as a matrix in...
- Pretreatment quality of life, performance status a...
- Differential role of microRNAs in the pathogenesis...
- Hypomineralised second primary molars: prevalence,...
- The Nation and the Family: The Impact of National ...
-
▼
Ιουν 04
(49)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου