Abstract
Objective
Dissect the aberrant microRNA profile of oral lichenoid disorders (OLD) by analyzing the larger set of OLD samples tested so far.
Materials and methods
MicroRNA expression profiles were assessed using TLDA card in 32 samples (16 OLD, 8 OSCC and 8 control). The findings were validated using RT-qPCR in an independent cohort of 91 samples.
Results
We identified 20 differentially expressed microRNAs in OLD of which several are functionally related to cell proliferation, response to organic substances or immune processes. Further validation of the top ranked microRNAs, revealed that they were all aberrantly expressed in OLD.
Conclusion
We have identified a new microRNA signature associated with OLD that may provide a meaningful basis for better understanding the physiopathology of the disease. In addition, we validated seven microRNAs whose expression showed to be higher in OLD tissue in comparison with the controls and OSCC tissues.
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