Phenotypic characterization of a pair of molecules in tissues confer to classical Mendelian or non Mendelian ratios

Publication date: September 2016
Source:Medical Hypotheses, Volume 94
Author(s): L.M. Suneetha, Prasanna Marsakatla, G.V. Ravi, Aparna Sykam, R. Raju, P.P. Reddy, V.V. Hara Gopal, R. Jadhav, S. Suneetha
Studies have reported a wide range of inflammatory responses in the nerve, skin and plasma of leprosy patients. The expression levels of each biomolecule was individualistic, however could be categorized as high and low based on their statistical mean level. Here we report for the first time, expression of a set of biomolecules relating with each other in a defined proportion.The hypothesis of this paper is that the segregation of high and low combinations of a set of biomolecules follows either classical Mendelian dihybrid ratio or epistatic ratios. This hypothesis was tested for 17 molecules in three tissues; nerve, skin and plasma and were confirmed to interact in 9:7, 9:3:4, 12:3:1, 13:3, 15:1 epistatic proportions. These findings suggest that there could be a significant role of networking of molecules in defined epistatic proportions and could be important in pathophysiology of peripheral nerve.



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