Plasma matrix metalloproteinases in stroke patients during intensive rehabilitation therapy

Publication date: Available online 1 July 2016
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Feifei Ma, Susana Rodriguez, Xavi Buxo, Anna Morancho, Iolanda Riba-Llena, Ana Carrera, Alejandro Bustamante, Dolors Giralt, Joan Montaner, Carmen Martinez, Immaculada Bori, Anna Rosell
ObjectiveTo study plasma levels of matrix metalloproteinases (MMPs) as potential markers of recovery during intensive rehabilitation therapy (IRT) after stroke.DesignProspective and descriptive 3-months follow-up study.SettingRehabilitation unit and research center.ParticipantsPatients with first-ever ischemic strokes (n=15) enrolled to IRT (≥3 hours per day/5 days per week) and healthy volunteers serving as non-ischemic controls (n=15).InterventionsNot ApplicableMain Outcome MeasuresThe primary outcome was to measure plasma MMP3, MMP12 and MMP13 levels and evaluate potential associations with motor/functional scales using a battery of tests (NIHSS, RANKIN, BI, FMA, FAC, MRC, CAHAI and the 10 meter walk) before IRT therapy and at one- and three-month follow-ups. The secondary outcome was to evaluate the use of these MMPs as biomarkers as predictors of patient's outcome.ResultsMMP levels remained stable during the study period and were similar to those in controls. However, baseline MMP12 and MMP13 levels were strongly associated with stroke severity and found elevated in those patients with the poorest outcomes. Interestingly, plasma MMP3 was independent of baseline stroke characteristics but was found to be increased in patients with better motor/functional recovery and in patients with larger improvements during rehabilitation.ConclusionsMMPS might act as biological markers of recovery during rehabilitation therapy related to their roles in both injury and tissue remodeling. Future confirmatory investigations in multicenter studies are warranted by our data.



from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/299Zsn2
via IFTTT