Exploiting CD22 on Antigen-Specific B-Cells to Prevent Allergy to the Major Peanut Allergen Ara h 2

Publication date: Available online 20 August 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Kelly A. Orgel, Shiteng Duan, Benjamin L. Wright, Soheila J. Maleki, John C. Wolf, Brian P. Vickery, A. Wesley Burks, James C. Paulson, Mike D. Kulis, Matthew S. Macauley

Teaser

Methods for inducing antigen-specific immune tolerance are needed for the treatment and prevention of food allergies. We demonstrate that mice can be tolerized to the major peanut allergen through engaging CD22, an inhibitory B-cell co-receptor.


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