Applicability and discriminative value of a semi-automatic 3D-spherical-volume for the assessment of the apparent-diffusion-coefficient in suspicious breast lesions – feasibility study

Publication date: Available online 4 September 2016
Source:Clinical Imaging
Author(s): Jan Hering, Frederik Bernd Laun, Wolfgang Lederer, Heidi Daniel, Tristan Anselm Kuder, Anne Stieber, Stefan Delorme, Klaus H. Maier-Hein, Heinz-Peter Schlemmer, Sebastian Bickelhaupt
IntroductionTo evaluate the feasibility and accuracy of a semi-automatic, three-dimensional volume-of-interest (3D-sphere) for measuring the apparent-diffusion-coefficient (ADC) in suspicious breast lesions compared to conventional single-slice 2D-regions-of-interest (2D ROI).MethodThis IRB-approved study included 56 participants with BIRADS 4/5 lesion. All received DWI-MRI prior biopsy (b=0–1500 s/mm²). ADC-values were measured in the lesions with both methods. Reproducibility and accuracies were compared.ResultsArea-under-the-curve (AUC) was 0.93 (95%-CI:0.86–0.99) for the 3D-sphere and 0.91 (95%-CI:0.84–0.98) for the 2D-ROI without significantly differing reproducibility (P=.45).ConclusionA semi-automatic 3D-sphere could reliably estimate ADC values in suspicious breast lesions without significant difference compared to conventional 2D-ROIs.



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