Bipolar electrograms characteristics at the left atrial-pulmonary vein junction: toward a new algorithm for automated verification of pulmonary vein isolation

BACKGROUND: Verification of pulmonary vein isolation (PVI) is challenging because of the coexistence of PV and far-field potentials in bipolar electrograms recorded at the Left atrial-pulmonary vein (LA-PV) junction. OBJECTIVE: The purpose of this study was to characterize algorithmically LA-PV potentials before and after PVI and to develop an algorithm to differentiate nonisolated from isolated PVs. METHODS: In 61 patients, we characterized by type (morphology) and parameters-1440 electrograms recorded during sinus rhythm before and after PVI. Based on vein-dependent prevalence of a given type before and after PVI (first step) and based on vein- and type-dependent cutoff values in parameters specific for recordings before and after PVI (second step), we developed a 2-step algorithm to differentiate nonisolated from isolated PVs. We prospectively validated this algorithm in another dataset of 20 patients. RESULTS: Characteristics before and after PVI were as follows: low voltage (10% +/- 7% vs 36% +/- 15%), monophasic (13% +/- 4% vs 27% +/- 9%), biphasic (18% +/- 4% vs 21% +/- 7 9%), triphasic (22% +/- 5% vs 11% +/- 13%), multiphasic (26% +/- 7% vs 3% +/- 3%), double potentials (11% +/- 5% vs 2% +/- 1%), peak-to-peak amplitude (0.97 +/- 0.21 mV vs 0.35 +/- 0.23 mV), maximal slope (0.179 +/- 0.033 mV/ms vs 0.071 +/- 0.029 mV/ms), minimal slope (0.030 +/- 0.003 mV/ms vs 0.024 +/- 0.002 mV/ms), and sharpest peak (1.82 degrees +/- 0.26 degrees vs 3.45 degrees +/- 0.85 degrees, P < .01 for all except biphasic). Overall sensitivity and specificity of the 2-step algorithm was 100% and 87%, respectively. CONCLUSION: We algorithmically characterized LA-PV potentials before and after PVI in a Large dataset (library of types and parameters). This library enabled us to develop an accurate 2-step algorithm to automatically differentiate nonisolated from isolated PVs. The 2-step algorithm is objective and reliable for assessing PV isolation without the need for pacing maneuvers.

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