Cashew Allergy Risks, 2S albumins, and Predictions based on IgE Antibody Levels

Abstract

We read with great interest the report of Lange et al (1) that studied cashew allergic children and the potential predictive value of cashew 2S albumin storage protein (Ana o 3)-specific IgE measurements in determining the need for an oral cashew challenge to prove disease. They report that IgE antibody levels >2 kU_A/l to Ana o 3 improved their prediction (95% probability) of a positive oral food challenge after cashew consumption in comparison to IgE against the whole cashew extract. In other words, increased analytical specificity of molecular Ana o 3-specific IgE testing (2) reportedly translates into an improved diagnostic efficacy and a superior prediction for a positive oral cashew challenge.

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