Systematic review and individual patient data analysis of pediatric head and neck squamous cell carcinoma: An analysis of 217 cases

Publication date: Available online 12 November 2016
Source:International Journal of Pediatric Otorhinolaryngology
Author(s): V. Bhanu Prasad, Supriya Mallick, Ashish Dutt Upadhyay, G.K. Rath
IntroductionPediatric head and neck Squamous cell carcinoma (PHNSCC) is a rare disease. The optimum treatment and outcome remains poorly understood because of rarity.MethodsWe conducted an individual patient data analysis of PHNSCC. Two authors independently searched PubMed, google search, and Cochrane library for eligible studies using following search words: Pediatric Head and neck squamous cell carcinoma, Head and neck squamous cell carcinoma under age of 20, Head and neck squamous cell carcinoma in young, PHNSCC till June 1, 2016 published in English language.ResultsTotal of 217 patients of PHNSCC were found in the literature. Median age among the cohort was 15 years (Range: 0–20 years) with a clear male preponderance. Oral cavity tumors were commonest 75 (70%) followed by laryngeal neoplasms 16(15%). Median disease free survival was 9 months (Range: 0–216 months). Median overall survival was 48 months (Range: 1–216 months). In univariate analysis treatment modality had significant impact on disease free survival (DFS). Whereas, patients treated with Surgery, Laryngeal primary had significantly better OS. Patients with associated fanconis anemia had significantly worse overall survival (OS).ConclusionPHNSCC is a rare disease with poorer outcome. Associated DNA defects leads to poorer OS. Patients treated with surgery alone or surgery followed by adjuvant radiation had better DFS and OS. Molecular profiling and personalized therapy may improve survival with limited toxicity.



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