The association between drugs and bullous pemphigoid

Abstract

Drug-induced bullous pemphigoid (DIBP) is often poorly defined in the existing literature from the classic, spontaneous form of bullous pemphigoid (BP). The pathogenesis is unclear and the association between bullous pemphigoid and various medications is tenuous^1-2.Commonly reported associations include neuroleptics^3-4and diuretics^{3, 5} with more recent literature drawing attention to dipeptidyl peptidase-4 inhibitors⁶.Strength of drug causality associations is generally determined by factors such as latency between drug initiation and onset of disease, epidemiological risk, effects of withdrawal/re-challenge. Prior drug association studies were based on broader inclusion criteria and may overestimate the true association^3-6.

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