Trypanosoma brucei metabolite indolepyruvate decreases HIF-1{alpha} and glycolysis in macrophages as a mechanism of innate immune evasion [Immunology and Inflammation]

The parasite Trypanasoma brucei causes African trypanosomiasis, known as sleeping sickness in humans and nagana in domestic animals. These diseases are a major burden in the 36 sub-Saharan African countries where the tsetse fly vector is endemic. Untreated trypanosomiasis is fatal and the current treatments are stage-dependent and can be...

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