HEPATIC EPITHELIOID HEMANGIO-ENDOTHELIOMA AND ADULT LIVER TRANSPLANTATION: PROPOSAL FOR A PROGNOSTIC SCORE BASED ON THE ANALYSIS OF THE ELTR-ELITA REGISTRY.

Background: Hepatic epithelioid hemangio-endothelioma (HEHE) is a rare vascular tumor which has an intermediate aggressive behavior. Although the value of liver transplantation (LT) is well established, its place in the management of HEHE is still unclear. The aim of this study is to confirm, based on a very large patient cohort, the value of LT in the management of HEHE and to identify risk factors for post-LT recurrence. Material and methods: the outcome of 149 transplant recipients with HEHE recorded in the European Liver Transplant Registry during the period November1984-May 2014 was analyzed. Median post-LT follow-up was 7.6 years (IQR=2.8-14.4). Results: Cox regression analysis showed that macro-vascular invasion (hazard ratio=4.8; p=6 (93.9 vs. 38.5%; p

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