Monitoring structural changes in Demodex mites under topical Ivermectin in Rosacea by means of Reflectance confocal microscopy: a case series

Abstract

Rosacea is a common inflammatory disease, mainly affecting the face and with significant impact on patients' life quality. Just recently, topical Ivermectin (Soolantra^® 10mg/g Crème) has been introduced in the treatment of rosacea thanks to its double anti-parasitic and anti-inflammatory activity, resulting in a reduction of papulo-pustular manifestations, blepharitis and cutaneous demodicosis.¹ Although the role of the human skin commensal Demodex folliculorum (DF) in the pathogenesis of the disease is still debated², numerous studied reported an abnormal increase in the density of mites (>5 mites/cm²) in patients affected by papulo-pustular rosacea, measured by regular and standardized superficial skin biopsy, skin scraping, PCR or reflectance confocal microscopy (RCM)^3-6.

This article is protected by copyright. All rights reserved.

http://ift.tt/2hQOLaG