Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells

Publication date: Available online 12 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Veronique Schulten, Victoria Tripple, Grégory Seumois, Yu Qian, Richard H. Scheuermann, Zheng Fu, Michela Locci, Sandy Rosales, Pandurangan Vijayanand, Alessandro Sette, Rafeul Alam, Shane Crotty, Bjoern Peters
Follicular helper T cells (Tfh cells) are a CD4 T cell subset essential for germinal center formation and B cell responses, although their role in allergy and allergen-specific immunotherapy (AIT) is unclear. Here, we show that AIT-treated patients have a higher ratio of regulatory Tfh cells (Tfr) to follicular T cells (Tfh) and hypothesize an IL-2 dependent mechanism.



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