Activation of phosphatidylinositol 3 kinase (PI3K), Ras, and Her2 signaling plays a critical role in cancer development. Hotspot constitutive activating mutations in oncogenes, such as PIK3CA encoding the p110α catalytic subunit or RAS, as well as overexpression of Her2, are frequently found in human tumors and cancers. It has been...
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Τρίτη 16 Μαΐου 2017
{Delta}Np63{alpha} is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis [Cell Biology]
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