Interstital lung disease in ANCA vasculitis

Publication date: Available online 4 May 2017
Source:Autoimmunity Reviews
Author(s): Marco A. Alba, Luis Felipe Flores-Suárez, Ashley G. Henderson, Xiao Hong, Peiqi Hu, Patrick H. Nachman, Ronald J. Falk, J. Charles Jennette
Anti-neutrophil cytoplasmic antibodies (ANCA) vasculitis are immune-mediated disorders that primarily affect small blood vessels of the airway and kidneys. Lung involvement, one of the hallmarks of microscopic polyangiitis and granulomatosis with polyangiitis, is associated with increased mortality and morbidity. In recent years, several retrospective series and case reports have described the association of interstitial lung disease (ILD) and ANCA vasculitis, particularly those positive for ANCA specific for myeloperoxidase. In the majority of these patients pulmonary fibrosis occurs concurrently or predates the diagnosis of ANCA vasculitis. More importantly, these studies have shown that ILD has an adverse impact on the long-term prognosis of ANCA vasculitis. This review focuses on the main clinical and radiologic features of pulmonary fibrosis associated with anti-neutrophil cytoplasmic antibodies. Major histopathology features, prognosis and therapeutic options are summarized.



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