Novel approaches to prevention of microbial infections after insertion of orthopedic external fixators are in great demand because of extremely high incidence rate of such infections, which can reach up to 100% for longer implant residence times. Monolaurin is an antimicrobial agent with known safety record, broadly used in food and cosmetic industries; however, its use in antimicrobial coatings of medical devices has not been studied in much detail. Here, we report the use of monolaurin as an antibacterial coating on external fixators for the first time. The monolaurin-coated Kirschner wires (K-wires) showed excellent antibacterial properties against three different bacterial strains – methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis. A ca. 6.0-log reduction of both planktonic and adherent bacteria was achieved, when using monolaurin-coated K-wires. At the same time, monolaurin-coated K-wires did not show any observable cytotoxicity with mouse osteoblast cell cultures. Overall, monolaurin-coated K-wires could be promising as potent antimicrobial materials for orthopaedic surgery.
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