Αρχειοθήκη ιστολογίου

Δευτέρα 19 Ιουνίου 2017

Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset

S00039969.gif

Publication date: October 2017
Source:Archives of Oral Biology, Volume 82
Author(s): Cüneyt A. Aral, Özlem Nalbantoğlu, Bilge G. Nur, Mustafa Altunsoy, Kübra Aral
ObjectiveRecently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment.DesignThe study groups were composed of 32 T1DM patients at diagnosis, and age- and gender-matched thirty-six systemically healthy children with (G) and without (H) gingivitis. The diabetic patients who took insulin therapy (1.5 units/kg/day totally) and periodontal treatment (oral hygiene education with professional scaling) were reevaluated after 3 months. The levels of total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were recorded.ResultsGCF, salivary, and serum OSI were elevated in group T1DM compared to the other groups at baseline (p<0.05), and decreased in group T1DM at reevaluation compared to baseline (p<0.05). GCF OSI was positively correlated with periodontal clinical parameters (p<0.05). Glycated hemoglobin was positively correlated with GCF TOS (r=0.302, p=0.007), GCF OSI (r=0.346, p=0.002), salivary TOS (r=0.326, p=0.046), and serum TOS (r=0.239, p=0.044).ConclusionThe instability in the oxidative status that accompanies diabetes may be considered a significant pathogenic factor of diabetes-related periodontal inflammation.



http://ift.tt/2sJY3Og

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου