Purpose of review: Mast cell disorders (MCDs) comprise mastocytosis and disorders referred to as mast cell activation syndrome and are caused by abnormal accumulation and/or activation of mast cells in tissues. Clinical signs and symptoms are protean; therefore, finding suitable treatment options for individual patients entails a challenge for clinicians. The purpose of this manuscript is to review the literature on the available therapeutic interventions in patients with MCD. Recent findings: Pharmacotherapy is mainly directed against the effects of mast cells and their mediators. The current recommendations are exclusively based on expert opinions due to the lack of controlled clinical trials. The targeted therapies aiming at blocking mutant KIT variants and/or downstream signaling pathways are currently being developed and may be considered in severely affected, therapy-refractory patients. Summary: There is currently no method for predicting the best available approach to control symptoms in individual patients with MCD. Therefore, a stepwise, individual-based approach in pharmacotherapy options appears to be most successful strategy and is recommended in all patients. The core component of the treatment in most patients is to control symptoms caused by mast cell mediator release, whereas cytoreductive therapies are mainly reserved for patients with advanced/aggressive systemic mastocytosis.
http://ift.tt/2tah9Lq
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
▼
Ιουνίου
(6967)
-
▼
Ιουν 30
(278)
- Letter to Editors: Detection of endolymphatic hydr...
- Solitary fibrous tumour of the pleura presenting a...
- Das endoskopische Browlift mittels Endotine Forehe...
- Hereditäre Innenohrdysplasie mit Betroffenheit von...
- Musikalische Fähigkeiten bei Kindern mit auditiver...
- Progrediente Verschlechterung des Sprachverstehens...
- Incidence of Hepatitis B Viral Reactivation After ...
- Aggregating Marginal Gains in Posttransplant CMV R...
- The use of Ex Vivo Generated Regulatory T Cell Pre...
- Non-HLA Antibodies Impact on C4d staining, Stellat...
- Letter to the editor
- Letter to Editors: Detection of endolymphatic hydr...
- Single-Injection Versus Multiple-Injection Techniq...
- Neuralgic Amyotrophy Attributed Incorrectly to Blo...
- Allergic contact dermatitis in preservatives: curr...
- Hypersensitivity reactions to gadolinium-based con...
- Alternative treatments for chronic spontaneous urt...
- Reactions to cytostatic agents in children
- Molecular aspects of allergens in atopic dermatitis
- Drug allergy/hypersensitivity in adults and children
- Allergen immunotherapy for the treatment of respir...
- Seasonal Allergic Rhinitis: A focused systematic r...
- Aspirin challenge and desensitization: how, when a...
- Editorial introductions
- Skin allergy
- Pharmacotherapy of mast cell disorders
- Atopic dermatitis phenotypes and the need for pers...
- Cholesteatoma as a complication of Langerhans Cell...
- Pediatric head and neck bone sarcomas: An analysis...
- Pathophysiology of esophageal impairment due to bu...
- Paediatric injection medialisation laryngoplasty: ...
- Disparities in access to pediatric hearing health ...
- Disparities in access to pediatric hearing health ...
- Cover 1
- Brief Overview of This Month's JACI
- Table of Contents
- Editorial Board
- Information for Readers
- News & Notes
- CME Activities Calendar
- Environmental determinants of allergy and asthma i...
- Environmental determinants of allergy and asthma i...
- The environment, epigenome, and asthma
- An exposome perspective: Early-life events and imm...
- The Editors' Choice
- News Beyond Our Pages
- The Journal of Allergy and Clinical Immunology: An...
- Association of Insurance and Community-Level Socio...
- Use of Audiometric Measurement for Assessment of V...
- Control of Pain After Tonsillectomy in Children: A...
- Unilateral Nasal Congestion in an Elderly Man.
- Antipodocalyxin Antibody chPcMab-47 Exerts Antitum...
- Different levels of let-7d expression modulate res...
- DIS on a polarized spin-1 target with spectator ta...
- Tensor-polarized structure function b1 in the stan...
- Tagged spectator DIS on a polarized spin-1 target
- Different levels of let-7d expression modulate res...
- Industry relationships are associated with perform...
- Prognostic value of nasal cytology and clinical fa...
- Quality measurement for rhinosinusitis: a review f...
- Increased expression of TIPE2 in alternatively act...
- Het Belgisch Nederlands anno 2017: verspreiding, j...
- Tussen droom en daad. De consequenties van de vera...
- Pectobacterium aroidearum and Pectobacterium carot...
- Lutibacter holmesii sp nov., a marine bacterium of...
- Lutibacter holmesii sp. nov., a marine bacterium o...
- VideoEndocrinology™ High-Impact Videos
- Approach for quantitative analysis of hordein pept...
- Erwinia gerundensis sp nov., a cosmopolitan epiphy...
- Multiple Locus Variable number of tandem repeat An...
- Impact of plant growth-promoting rhizobacteria on ...
- De stadsenclave. Van militair hospitaal tot Groen ...
- Genetic characterization of strains named as Xanth...
- City
- De kwaliteit van de gehechtheidsrelaties in kaart ...
- Gehechtheid voor (cognitieve) gedragstherapeuten. ...
- 24th European Childhood Obesity Group (ECOG) Meeti...
- Impact of the freeze-drying process on product app...
- Description of Pseudomonas gregormendelii sp nov.,...
- Michael Miller Named Director of Biomedical Engine...
- Role of sialendoscopy in juvenile recurrent paroti...
- Bronchoprotective tolerance with indacaterol is no...
- Comorbidities in adults with asthma: population-ba...
- Critical airways, critical language
- Predicting delirium: are we there yet?
- Association of intraoperative changes in brain-der...
- Pemphigus : vers une réduction drastique de la cor...
- Éducation thérapeutique du patient dans la dermati...
- La photographie en dermatologie. Questions éthiques
- Traitement de la maladie de Hailey-Hailey par toxi...
- Phenotypic and molecular insights into CASK-relate...
- Postnatal Maturation of the Glomerular Filtration ...
- Integrating Form and Meaning in L2 Pronunciation I...
- The conventional pig as PK/PD/toxicity model for t...
- De Martinitoren / La Tour Martini / The Martini To...
- Gene expression profiling of osteosarcoma
- Gene expression data annotation, effective storage...
- Distribution of Salivary Testosterone in Men and W...
- Spatial processing is frequency-specific in audito...
- Two-way DF relaying assisted D2D communication: er...
-
▼
Ιουν 30
(278)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου