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Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities.
Oncotarget. 2017 Jul 18;:
Authors: Xia AL, Wang XC, Lu YJ, Lu XJ, Sun B
Abstract
Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have been shown to have unprecedented efficacy in B cell malignancies, most notably in B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate using anti-CD19 CAR-T cells. However, CAR T-cell therapy for solid tumors currently is faced with numerous challenges such as physical barriers, the immunosuppressive tumor microenvironment and the specificity and safety. The clinical results in solid tumors have been much less encouraging, with multiple cases of toxicity and a lack of therapeutic response. In this review, we will discuss the current stats and challenges of CAR-T cell therapy for solid tumors, and propose possible solutions and future perspectives.
PMID: 28740018 [PubMed - as supplied by publisher]
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