Publication date: Available online 1 July 2017
Source:Annals of Allergy, Asthma & Immunology
Author(s): Robert D. Pesek, Mallikarjuna Rettiganti, Erin O'Brien, Sarah Beckwith, Caroline Daniel, Chunqiao Luo, Amy M. Scurlock, Peggy Chandler, Rebecca A. Levy, Tamara T. Perry, Joshua L. Kennedy, Sheva Chervinskiy, Maryelle Vonlanthen, Helen Casteel, Stephen C. Fiedorek, Troy Gibbons, Stacie M. Jones
BackgroundIn children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits.ObjectiveTo determine the effects of environmental allergen sensitization on response to treatment in children with EoE in the southeastern United States.MethodsPatients 2 to 18 years old who were referred to the Arkansas Children's Hospital Eosinophilic Gastrointestinal Disorders Clinic from January 2012 to January 2016 were enrolled in a prospective, longitudinal cohort study with collection of demographics, clinical symptoms, medical history, allergy sensitization profiles, and response to treatment over time. Comparisons were made between complete responders (peak esophageal eosinophil count <15 per high-power field [HPF]) and nonresponders (>25 eosinophils per HPF) after treatment with diet elimination alone, swallowed corticosteroids alone, or diet elimination and swallowed corticosteroids. Sensitization patterns to environmental allergens found in the southeastern United States were analyzed for the effect on treatment response.ResultsA total of 223 individuals were enrolled. Of these, 182 had environmental allergy profiling and at least one endoscopy while receiving proton pump inhibitor (PPI) therapy. Twenty-nine individuals had PPI-responsive EoE and were excluded from further analysis, leaving 123 individuals with non–PPI-responsive EoE who were further analyzed; 72 (58.5%) were complete responders and 33 (26.8%) were nonresponders. Seventeen individuals (13.8%) were partial responders (≥1 but ≤25 eosinophils per HPF) and excluded from further analysis. Nonresponders were more likely to be sensitized to perennial allergens (P = .02). There was no significant difference in response based on seasonal allergen sensitization. Individuals with mold or cockroach sensitization were more likely to fail combination diet and swallowed corticosteroid treatment (P = .02 and P = .002).ConclusionPerennial allergen and mold sensitization may lead to nonresponse to EoE treatment in some patients. Additional studies are needed to further understand the effect of environmental allergens on EoE.Trial RegistrationClinicalTrials.gov identifier: NCT01779154.
http://ift.tt/2tEfrFp
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
▼
Ιουλίου
(4578)
-
▼
Ιουλ 02
(66)
- Head and Neck Diseases
- Consecutive occurrence of isotopic and isomorphic ...
- Superficial plantar angiomyxoma in a young man
- The dog days or dog days of summer are the hot, su...
- Brassica rapa hairy root extracts promote skin dep...
- Subcutaneous mycoses in Peru: a systematic review ...
- A Case of Atopic Myelitis with Cervical Cavernous ...
- A call to arms of specialty societies to review th...
- The atopic disorders and atopy … “strange diseases...
- Atopic dermatitis treatment: Current state of the ...
- Efficacy and safety of omalizumab in children and ...
- A 6-month safety and efficacy study of fluticasone...
- Asthma in older people hospitalized with influenza...
- Prevalence and triggers of anaphylactic events in ...
- Seasonal variation and monthly patterns of skin sy...
- Association of maternal depression and allergic di...
- A 10-year experience of a novel and safe modified ...
- Pearls and pitfalls: Autoimmune lymphoproliferativ...
- A 28-year-old woman with fever, rash, and pancytop...
- For the Patient: Prevalence and triggers of anaphy...
- Abstracts from the New England Society of Allergy ...
- Assessment of complete unilateral cleft lip and pa...
- NCI UNC Project ESCC
- Eltrombopag for People With Fanconi Anemia
- Contributors
- Contents
- Skin and Composite Grafting Techniques in Facial R...
- Defect of the Eyelids
- Flap Basics III
- Forthcoming Issues
- Flap Basics II
- Index
- Repair of Auricular Defects
- Facial Reconstruction Post-Mohs Surgery
- Reconstruction of Mohs Defects of the Lips and Chin
- Reconstruction of Cheek Defects Secondary to Mohs ...
- Copyright
- In Pursuit of Perfection: The Art of Facial Restor...
- Effects of allergen sensitization on response to t...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Corrigendum to “Management Challenges in a Child w...
- Efficacy of oral immunotherapy with a rice-based e...
- Sertoli-Leydig Cell Tumor with Concurrent Rhabdomy...
- Palate perforation differentiates cocaine-induced ...
- Cost-effectiveness strategies in OSAS management: ...
- Prognostic factors in head and neck cancer: a 10-y...
- An aspect of the object habit: Pliny the Elder, au...
- Consensus-based guidelines for Video EEG monitorin...
- Calling all health professionals for a safer, fair...
- Invasion of the bloggers: A preliminary study on t...
- Opicapone for the management of end-of-dose motor ...
- The relationship between the First World War and n...
- Influence of the drug distribution in electrospun ...
- Finding the grave of Sir William Richard Gowers.
- Concerns Regarding Opicapone as Adjunct to Levodop...
- Association of Autonomic Dysfunction With Disease ...
- Time from HIV seroconversion to death: a collabora...
- Classification of drug-resistant tuberculosis.
- Cause of death and presence of respiratory disease...
- Estimating ‘net’ HIV-related mortality and the imp...
- The Long-term Effects of Early Track Choice
- Buckling in armored droplets.
- Water Oxidation Kinetics of Accumulated Holes on t...
- Late recovery of awareness in prolonged disorders ...
- Endoscopic Depth Measurement and Super-Spectral-Re...
- Fast Estimation of Haemoglobin Concentration in Ti...
-
▼
Ιουλ 02
(66)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου