Publication date: September 2017
Source:Oral Oncology, Volume 72
Author(s): Douglas Adkins, Jessica Ley, Peter Oppelt, Tanya M. Wildes, Hiram A. Gay, Mackenzie Daly, Jason Rich, Randal C. Paniello, Ryan Jackson, Patrik Pipkorn, Brian Nussenbaum, Kathryn Trinkaus, Wade Thorstad
ObjectivesTo explore the effect of incorporating cetuximab into induction chemotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC).Materials and methodsRetrospective comparative analysis of two consecutive prospective phase II trials was performed: trial 1 with nab-paclitaxel/cisplatin/5-FU and cetuximab (APF-C; n=30) and trial 2 with APF (n=30). Patients were scheduled to receive chemoradiation therapy (CRT) with cisplatin. T2-4 classification oropharynx (OP)/larynx/hypopharynx SCC were included. Cumulative incidence of death of disease (CIDD), overall survival (OS), and cumulative incidence of relapse were compared between APF-C and APF.ResultsNo significant differences in patient or tumor characteristics were noted between the groups. Median follow-up of surviving patients was 52 (25–95) months. Relapse occurred in 5 (17%) patients treated with APF-C and in 2 (7%) treated with APF (p=0.37). In human papillomavirus (HPV)-related OPSCC (n=34), the CIDD at 52months was 3.4% with APF-C and 2.6% with APF and the two-year OSs were 94%. In HPV-unrelated HNSCC (n=25), the CIDD at 52months was 4.4% with APF-C and 3.3% with APF and two-year OSs were 83% and 92%, respectively. CIDD or OS did not differ when stratified by treatment group and HPV status (CIDD: p=0.80; OS: p=0.30).ConclusionThis exploratory retrospective comparative analysis demonstrated no significant difference in CIDD, OS, or cumulative incidence of relapse between patients treated with APF-C or APF.
http://ift.tt/2uYawf8
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
▼
Ιουλίου
(4578)
-
▼
Ιουλ 09
(67)
- Therapeutic experience with oral finasteride for a...
- Seabather's eruption caused by the thimble jellyfi...
- Complex autonomic pathways in patients with idiopa...
- Clarithromycin, rifampicin and fusidic acid triple...
- Serial D-dimer plasma levels in a patient with chr...
- Comprehensive profiling of H-Ras signalling in ang...
- Acquired reactive perforating collagenosis associa...
- Systemic lupus erythematosus, following prodromal ...
- Peanut allergy and isotretinoin: reply to McCarthy...
- Treatment of paediatric facial pyogenic granuloma ...
- Millennarian Cinema: David Claerbout and "Olympia"
- Eruptive vellus hair cysts of the vulva
- Endothelial cells: From innocent bystanders to act...
- Circulating CXCL10 is increased in non-segmental v...
- Biomarkers of disease activity in vitiligo: A syst...
- Spasticity in multiple sclerosis: Contribution of ...
- Does type-I interferon drive systemic autoimmunity?
- Bile Acids and Intestinal Microbiota in Autoimmune...
- New Onset Insomnia in a Pediatric Patient: A Case ...
- Outcome, Pain Perception, and Health-Related Quali...
- Influence of the RPL34 gene on the growth and meta...
- nab-Paclitaxel-based induction chemotherapy with o...
- IFNɣ Block, Treosulfan Conditioning and αβ T Cell ...
- Causality in acute encephalitis: defining aetiolog...
- Guideline for the diagnosis, treatment and respons...
- Investigation and management of IgM and Waldenströ...
- Self-Healing, Self-Assembled β-Sheet Peptide-Poly(...
- To Brexit or not to Brexit: The roles of Islamopho...
- Pyramidal tract activation due to subthalamic deep...
- Nonparametric Estimation of the Leverage Effect: A...
- Preliminary research on monitoring the durability ...
- The treatment paradox: Not necessarily ...
- Plan, scan, model, print, manufacture, and implant...
- Structural Investigation of an Immunoglobulin Doma...
- Metering and dispensing of powder; the quest for n...
- ‘Local Film Subjects’: Suburban Cinema, 1895-1910
- The Cine-Tourist’s Map of New Wave Paris
- The New Wave Hotel
- Microfeeding with different ultrasonic nozzle desi...
- Lumière, Méliès, Pathé & Gaumont: French filmmakin...
- Mapping Out 1: Thirteen Cartographic Footnotes
- Mapping Out 1: thirteen cartographic footnotes
- Parental Actionability of Educational Materials Re...
- Addressing the Challenges in Tonsillectomy Researc...
- Addressing the Challenges for Otolaryngology Resea...
- Etiologic and Audiologic Characteristics of Patien...
- IL-33 improves wound healing through enhanced M2 m...
- Is endoscopic third ventriculostomy superior to sh...
- Angiogram negative subarachnoid haemorrhage: Outco...
- Early years neurosurgical training in the era of t...
- Early single centre experience of flow diverting s...
- Evans' index revisited: the need for an alternativ...
- Systematic review of the outcome of shunt surgery ...
- An investigation into the clinical impacts of lowe...
- Surgically managed idiopathic intracranial hyperte...
- Surgical management of idiopathic normal pressure ...
- The role of ICP monitoring in patients with persis...
- The predictive value of DESH for shunt responsiven...
- Elective ICP monitoring: how long is long enough?
- Persistent hydrocephalus due to postural activatio...
- Effect of venous stenting on intracranial pressure...
- Shunting of the over 80s in normal pressure hydroc...
- Childhood cognitive ability and age-related change...
- Packing of soft asymmetric dumbbells
- Collapsing nanoparticle-laden nanotubes
- Functional outcomes following immediate repair of ...
- Self injection of foreign materials into the penis
-
▼
Ιουλ 09
(67)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου