Insulin-Like Growth Factor-II mRNA-Binding Protein 3 as a Novel Prognostic Biomarker for Acral Lentiginous Melanoma

Acral lentiginous melanoma (ALM) is a distinctive histopathological subtype of melanoma that typically occurs on the palms, soles, and nail beds. Because of their anatomical locations, ALMs are typically diagnosed at late stages, resulting in a poor prognosis.¹ Insulin-like growth factor-2 mRNA-binding protein 3 (IMP-3) plays significant roles in cell proliferation, migration, and adhesion by enhancing IGF-2 protein expression in malignant tumours.² We evaluated the associations between IMP-3 expression and clinicopathological features, including the western blot profile, Ki-67 index, BRAF mutation, and long-term survival, among patients with ALM.

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