Mutations at the ribosomal S10 gene in clinical strains of Staphylococcus aureus with reduced susceptibility to tigecycline [PublishAheadOfPrint]

Mutations on the tip of the extended loop of ribosomal S10 protein have been associated with tigecycline (TGC) resistance in passaged mutants of different bacteria species. This study described the first two clinical TGC-resistant Staphylococcus aureus isolates with these mutations. One strain (TGC-MIC=2 mg/L) had a 12-nucleotide deletion affecting residues 56 to 59 (HKYK) of the S10 protein. The second strain (TGC-MIC=1 mg/L) had amino-acid substitutions (K57M, Y58F) previously described in S. aureus passaged mutants.

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