Synthesis of Methyl 4-(7-hydroxy-4,4,8-trimethyl-3-oxabicyclo[3.3.1]nonan-2-yl)benzoate and their evaluation as anti-leishmanial: Synergistic effect with Miltefosine [PublishAheadOfPrint]

In perpetuation of our interest in oxabicyclic compounds as potent anti-leishmanial, the present work deals with the chemical synthesis of new oxabicyclic derivative Methyl 4-(7-hydroxy-4,4,8-trimethyl-3-oxabicyclo[3.3.1]nonan-2-yl)benzoate (PS-207). This oxabicyclic derivative showed good anti-leishmanial effect on the parasite, both on promastigote and amastigote stages. The mode of parasitic death after PS-207 seems to be apoptotic. Interestingly, the combination of PS-207 with low dose of miltefosine showed synergistic effect against the parasite.

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