The comparative in vitro activity of relebactam, imipenem and the combination of the two, plus six comparator antimicrobial agents against 432 strains of anaerobic organisms including imipenem-resistant strains. [PublishAheadOfPrint]

Relebactam is an important beta-lactamase inhibitor for certain aerobic organisms but alone it has no anti-anaerobic activity, with most anaerobes having MICs ≥32 μg/ml with the exception of a very few strains. There was no enhancement or antagonism of imipenem activity with the addition of relebactam, including activity against imipenem resistant strains. The relebactam-imipenem combination had excellent overall activity against the anaerobes tested.

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