Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade [Immunology and Inflammation]

Antibodies that attenuate immune tolerance have been used to effectively treat cancer, but they can also trigger severe autoimmunity. To investigate this, we combined anti–CTLA-4 treatment with a standard colitis model to give mice a more severe form of the disease. Pretreatment with an antibiotic, vancomycin, provoked an even more...

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