Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children

Abstract

Mutations in FLG are the underlying cause of ichthyosis vulgaris and are an important predisposing factor for atopic dermatitis (AD).¹ In 2011, FLG mutations were reported to increase the risk of peanut allergy², and they have been proven to increase the risk of other food sensitizations and allergies.^3,4 In this study, we comprehensively screened 411 children in Japan for 10 Japanese-population-specific FLG mutations and suggested that FLG mutations influence the persistence of food allergies (FAs).

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