Αρχειοθήκη ιστολογίου

Παρασκευή 5 Ιανουαρίου 2018

Participation of the Th17 response in the pathogenesis of oral lichen planus

Abstract

Lichen planus is a chronic noninfectious inflammatory mucocutaneous disease that affects the skin, nails and mucosae, including the oral mucosa.1 Although the etiology of oral liquen planus (OLP) remains not fully elucidated, it is recognized that its pathogenesis arises from an immune-mediated response and many authors suggest the disease to be an autoimmune process.2-5 Despite the high prevalence and well-defined cytotoxic activity of CD8+ T lymphocytes against keratinocytes of the basal layer of the epithelium in OLP, helper CD4+ T lymphocytes also play an important role in the pathogenesis of this disease.6

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